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"first" : false, "last" : true, "author" : { "otype" : "Author", "mtid" : 10020644, "link" : "/api/author/10020644", "label" : "Hunyadi Attila (Farmakognózia)", "familyName" : "Hunyadi", "givenName" : "Attila", "published" : true, "oldId" : 10020644, "snippet" : true }, "familyName" : "Attila", "givenName" : "Hunyadi", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 26581226, "snippet" : true } ], "title" : "Angiotensin-Converting Enzyme inhibition by phenolic compounds isolated from the root bark of Morus nigra", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 21668037, "link" : "/api/publicationidentifier/21668037", "label" : "autopszia", "source" : { "otype" : "PlainSource", "mtid" : 15, "link" : "/api/publicationsource/15", "label" : "autopszia", 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The black \nmulberry tree, Morus nigra L.(Moraceae), is known for its \nvery high total phenolic and flavonoid content, making it the \nrichest source of such compounds when compared to other Morus \nspecies. The root bark of M. nigra has been reported to \npossess a broad range of bioactivities including \nantihypertensive effect, supporting its related traditional \nuse2. Nevertheless, only limited information is available on \nthe ACE inhibitory activity of this drug or its constituents.\nIn the present study, a methanolic extract of M. nigra root \nbark was subjected to a phytochemical study through the \nconsecutive use of various preparative chromatographic \ntechniques, leading to the isolation and characterization of \nseven phenolic compounds. Their chemical structures were \nelucidated by one- and two-dimensional NMR spectroscopy and \nHRMS, identifying them as prenylated arylbenzofurans such as \nMoracin P (1) and Moracin R (2), and prenylated flavonoids \nsuch as Kuwanon U (3), Morusin (4), Kuwanon E (5), Albanol A \n(6) and Albanol B (7). Compounds 1-7 were evaluated for their \npotential to inhibit ACE in vitro. Our preliminary results \nrevealed the highest ACE inhibition activity for compounds 5-\n7, each showing a complete inhibition of the enzyme at a \nconcentration of 36.4 μg/mL, whereas compound (3) exhibited \nnearly 50% inhibition at the same concentration.\nOur results suggest that M. nigra is an excellent source of \npotentially anti-hypertensive compounds, and that ACE \ninhibition by its prenylated phenolic compounds might provide \na rationale for its related traditional use.", "subjects" : [ { "otype" : "Classification", "mtid" : 12184, "link" : "/api/classification/12184", "label" : "Farmakológia és gyógyszerészet", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12187, "link" : "/api/classification/12187", "label" : "Gyógyszerismeret", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2017, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : false, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-28", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10028925, "link" : "/api/admin/10028925", "label" : "Kiss Tivadar (SZTE GYTK admin5 Farmakognózia)", "familyName" : "Kiss", "givenName" : "Tivadar", "published" : true, "oldId" : 10028925, "snippet" : true }, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "wosScopusCitationCount" : 0, "wosScopusCitationCountWoOther" : 0, "wosScopusIndependentCitationCount" : 0, "wosScopusIndependentCitationCountWoOther" : 0, "independentCitationCount" : 0, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "citingPubCountWoOther" : 0, "independentCitingPubCountWoOther" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 0, "citedCount" : 0, "hasCitationDuplums" : false, "userChangeableUntil" : "2017-07-02T12:29:52.000+0000", "publishDate" : "2017-07-02T12:29:47.000+0000", "directInstitutesForSort" : "Farmakognóziai Intézet (SZTE / GYTK); Természetes Vegyületek Interdiszciplináris Központ (SZTE / KE)", "ownerAuthorCount" : 5, "ownerInstituteCount" : 17, "directInstituteCount" : 2, "authorCount" : 5, "contributorCount" : 0, "book" : { "otype" : "Book", "mtid" : 3245169, "link" : "/api/publication/3245169", "label" : "Céline Rivière. 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