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Conventional well logging methods based on the use of limited number of wireline logs make only a quick-look interpretation, in which a limited number of unknowns is determined, and there is a non-negligible risk for occurrence of ambiguity. In order to increase the overdetermination (data-to-unknowns) ratio and the estimation accuracy and reliability, all suitable well logs are to be jointly processed in a more effective manner. To estimate the total organic carbon content together with porosity, water saturation, shale content and rock matrix volumes with higher accuracy, a new inversion methodology is introduced that is tested in tight gas reservoirs. A differential evolution algorithm-based interval inversion method is developed that is combined by nano-permeability and high precision porosity laboratory measurements for the detection and evaluation of Hungarian tight gas reservoirs. Spectral gamma-ray, neutron-porosity and electric resistivity logs are jointly analyzed using the interval inversion approach. By solving a highly overdetermined inverse problem, the effective porosity, water- and gas saturation, shale and sand content, as well as the kerogen volume are estimated in a reliable inversion procedure. The silt and clay content of Miocene tight gas formations are separated and both determined by inversion, while the total organic carbon content is derived from the inversion results. The permeability log is directly derived from the inverted porosity values using the local porosity versus permeability relation established by multi-well core analysis. The combination of in situ wireline log data analysis and porosity and nano-permeability laboratory measurements is shown to be advantageous for a more reliable interpretation of unconventional hydrocarbon formations. An added advantage of the interval inversion method is the calculation of depth dependent errors of the estimated petrophysical quantities. It is shown that total organic carbon and other volumetric parameters can be determined with high accuracy in one interpretation procedure. In the Derecske basin, East Hungary, gas indications are confirmed by interval inversion, that were previously made it probable according to measurements made on poor core samples and rather noise-sensitive local well logging inversion procedure. The joint evaluation of new core data and original wireline logs using the proposed methodology may reveal further potential tight gas resources in the studied area. 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