The aim of this study was to examine the effects of carba cyclic phosphatidic acid
(ccPA) on cornified envelope (CE) formation and keratinocyte differentiation. ccPA-treated
keratinocytes showed higher mRNA and protein levels of differentiation markers and
CE components than untreated cells. These results suggest that ccPA could serve as
therapeutic targets for treating skin barrier dysfunction because of their roles in
upregulating genes and proteins associated with CE formation and keratinocyte differentiation.
