European Union’s Horizon 2020 research and innovation programme(694679)
(K131458)
(PD131839)
(K132439) Támogató: NKFIH
Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató:
Innovációs és Technológiai Minisztérium
(Molecular Biology Thematic Programme of Semmelweis University)
Signaling networks represent the molecular mechanisms controlling a cell's response
to various internal or external stimuli. Most currently available signaling databases
contain only a part of the complex network of intertwining pathways, leaving out key
interactions or processes. Hence, we have developed SignaLink3 (http://signalink.org/),
a valueadded knowledge-base that provides manually curated data on signaling pathways
and integrated data from several types of databases (interaction, regulation, localisation,
disease, etc.) for humans, and three major animal model organisms. SignaLink3 contains
over 400 000 newly added human protein-protein interactions resulting in a total of
700 000 interactions for Homo sapiens, making it one of the largest integrated signaling
network resources. Next to H. sapiens, SignaLink3 is the only current signaling network
resource to provide regulatory information for the model species Caenorhabditis elegans
and Danio rerio, and the largest resource for Drosophila melanogaster. Compared to
previous versions, we have integrated gene expression data as well as subcellular
localization of the interactors, therefore uniquely allowing tissue-, or compartment-specific
pathway interaction analysis to create more accurate models. Data is freely available
for download in widely used formats, including CSV, PSI-MI TAB or SQL.
