https://m2.mtmt.hu/ hun 2026-09-22 20:17 JournalArticle 32346480 VALIDATED true 0 false 2026-08-27T16:10:55.540+0000 2022-02-23T13:45:33.430+0000 2021-10-12T02:55:23.857+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin true 2026-03-25T17:14:18.323+0000 2026-03-25T17:14:18.323+0000 2021-11-02T19:58:19.479+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin true 2022-07-13T05:19:21.044+0000 true 568 Áts József /api/admin/568 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2026-04-14T13:01:34.757+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Popovics-Toth, Nora Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones true true /api/journal/1413472 REVIEWED true false 1413472 false 1413472 true 1477-0520 1477-0539 Journal FOREIGN 19 40 8754 8760 8754 7 2021 A new method for the synthesis of 3-oxoisoindolin-1-ylphosphine oxides bearing same or different substituents on the phosphorus atom is described. The one-pot three-component reaction of 2-formylbenzoic acid, primary amines and achiral or P-stereogenic secondary phosphine oxides provided the target compounds under catalyst-free, mild conditions and for short reaction times. The deoxygenation of a 3-oxoisoindolin-1-ylphosphine oxide was also studied, and the phosphine obtained could be converted to a sulphide and to a platinum complex. The crystal structures of a selected phosphine oxide and the corresponding platinum species were investigated by X-ray diffraction analysis. The biological activity, such as in vitro cytotoxicity on different cell lines and antibacterial activity of the 3-oxoisoindolin-1-ylphosphine oxides was also investigated. Based on the IC50 values obtained, several derivatives showed moderate activity against the HL-60 cell line and two compounds containing 3,5-dimethylphenyl groups on the phosphorus atom showed promising activity against Bacillus subtilis bacteria. 2021 true true true false true false GOLD 2026-08-27 true https://doi.org/10.1039/d1ob01610e 17 0 17 14 5 17 17 13 14 16 16 13 13 14 3 0 17 14 17 14 0 4 4 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 3 1 3 1 2023 0 2 2 2 2 2024 0 3 2 3 2 2025 0 5 5 5 5 2026 0 4 4 4 4 Q1 false 10030275 false false false 2021-11-01T19:58:19.024+0000 Műszercentrum (TTK); Szerves Kémia és Technológia Tanszék (BME / VBK) 7 20 2 10 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 98330838 /api/authorship/98330838 1 0.1 true false false Author 10058314 /api/author/10058314 Popovics-Tóth Nóra true 10058314 true Popovics-Toth Nora true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330839 /api/authorship/98330839 2 0.1 false false false Author 10081859 /api/author/10081859 Rávai Bettina true true Ravai Bettina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330840 /api/authorship/98330840 3 0.1 false false false Author 10048077 /api/author/10048077 Tajti Ádám true 10048077 true Tajti Adam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330841 /api/authorship/98330841 4 0.1 false false false Author 10063224 /api/author/10063224 Varga Bence true 10063224 true Varga Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330842 /api/authorship/98330842 5 0.1 false false false Author 10042461 /api/author/10042461 Bagi Péter true 10042461 true Bagi Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330843 /api/authorship/98330843 6 0.1 false false false Perdih Franc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330844 /api/authorship/98330844 7 0.1 false false false Author 10014589 /api/author/10014589 Szabó Pál Tamás true 10014589 true Szabo Pal Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330845 /api/authorship/98330845 8 0.1 false false false Hackler Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330846 /api/authorship/98330846 9 0.1 false false false Puskas Laszlo G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98330847 /api/authorship/98330847 10 0.1 false true true Author 10030275 /api/author/10030275 Bálint Erika true 10030275 true Balint Erika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19729827 /api/publicationidentifier/19729827 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1039/d1ob01610e https://doi.org/10.1039/d1ob01610e false true PublicationIdentifier 19729826 /api/publicationidentifier/19729826 PlainSource 1 /api/publicationsource/1 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34581392&dopt=Abstract false true PublicationIdentifier 31569505 /api/publicationidentifier/31569505 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://xlink.rsc.org/?DOI=D1OB01610E https://xlink.rsc.org/?DOI=D1OB01610E false true Classification 10293 /api/classification/10293 true true SjrRating 11203516 /api/sjrrating/11203516 38 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 true 1605 true Q1 DIRECT true true /api/publication/32346480 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10058314"><a href="/gui2/?type=authors&mode=browse&sel=10058314" target="_blank">Popovics-Toth Nora (<span class="authorship-author-name">Popovics-Tóth Nóra</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081859"><a href="/gui2/?type=authors&mode=browse&sel=10081859" target="_blank">Ravai Bettina (<span class="authorship-author-name">Rávai Bettina</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048077"><a href="/gui2/?type=authors&mode=browse&sel=10048077" target="_blank">Tajti Adam (<span class="authorship-author-name">Tajti Ádám</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063224"><a href="/gui2/?type=authors&mode=browse&sel=10063224" target="_blank">Varga Bence (<span class="authorship-author-name">Varga Bence</span> <span class="authorAux-mtmt"> kémiai tudományok</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042461"><a href="/gui2/?type=authors&mode=browse&sel=10042461" target="_blank">Bagi Peter (<span class="authorship-author-name">Bagi Péter</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Perdih Franc </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014589"><a href="/gui2/?type=authors&mode=browse&sel=10014589" target="_blank">Szabo Pal Tamas (<span class="authorship-author-name">Szabó Pál Tamás</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Műszercentrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hackler Laszlo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Puskas Laszlo G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030275"><a href="/gui2/?type=authors&mode=browse&sel=10030275" target="_blank">Balint Erika ✉ (<span class="authorship-author-name">Bálint Erika</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32346480" target="_blank">Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones</a></div> <div> <span class="journal-title">ORGANIC & BIOMOLECULAR CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-0520">1477-0520</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-0539">1477-0539</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">40</span> <span class="page"> pp 8754-8760 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1039/d1ob01610e" target="_blank" href="https://doi.org/10.1039/d1ob01610e"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000700539500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000700539500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117266754" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117266754"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34581392" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34581392&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://xlink.rsc.org/?DOI=D1OB01610E" target="_blank" href="https://xlink.rsc.org/?DOI=D1OB01610E"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 14 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;14 | WoS/Scopus jelölt:&nbsp;16 | DOI jelölt:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32346480&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32346480</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2022.02.23. 14:45 Szabó Pál Tamás (Tömegspektrometria) </div> <div class="lockedBy">Központi kezelésű 2026.04.14. 15:01 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>