https://m2.mtmt.hu/hun2026-09-23 00:05JournalArticle32337511APPROVEDtrueLaboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, H-1521, Hungary
Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, ELKH Eötvös Loránd Research Network, Budapest, H-1519, Hungary
Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, H-6720, Hungary
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, H-6720, Hungary
Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Budapest, H-1085, Hungary
Export Date: 30 November 2021
Correspondence Address: Cui, L.; Laboratory of Plastics and Rubber Technology, Hungary; email: biluoyunduan@gmail.com
Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, BME IE-NAT TKP2020
Funding text 1: Funding: This research was funded by BME Nanotechnology and Materials Science TKP2020 IE grant from NKFIH Hungary, grant number BME IE-NAT TKP2020.0false2026-07-11T19:14:12.971+00002025-02-25T22:44:54.272+00002021-10-11T06:57:03.033+0000true10018804Szalóky-SikiÁgnes
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Categorytrue1Cui, LuPhysical–Chemical Aspects of the Preparation and Drug Release of Electrospun Scaffoldstruetrue
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REVIEWEDtruefalse10022148false10022148true1999-4923JournalFOREIGN131016451645152021Fibers were spun from a mixture of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) solution of poly(lactic acid)(PLA) containing various amounts of amoxicillin (Amox) as the active component. Composition changes during spinning, structure, solubility, and the location of the drug were considered during the evaluation of drug release and microbial activity. The results showed that the composition of the material changes during the preparation procedure. The solubility of the drug in the components and that of the components in each other is limited, which results in the formation of several phases and the precipitation of the drug. The technology used results in the partitioning of the drug; some is located inside, while the rest is among the fibers. The wetting of the fibers or disks by the water-based dissolution media is poor, the penetration of the liquid into and the diffusion of the active component out of the device takes considerable time. Drug release takes place in one, burst-like step, only Amox located among the fibers dissolve and diffuse into the surrounding medium. The slow second stage of release claimed in the literature is less probable because the size of the Amox molecule is considerably larger than the holes creating the free volume of the polymer. The prepared device has antimicrobial activity, inhibits the growth of the two bacterial strains studied. The time scale of activity is short and corresponds to that of the release experiments and the burst-like behavior of the device. The results clearly prove that physical–chemical factors play a determining role in the effect and efficiency of medical devices prepared from electrospun fibers containing an active component.Funding2009173
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10065131"> <a href="/gui2/?type=authors&mode=browse&sel=10065131" target="_blank">Cui, Lu ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Molnár, Judit Rebeka </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032093"> <a href="/gui2/?type=authors&mode=browse&sel=10032093" target="_blank">Budai-Szűcs, Mária</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10025300"> <a href="/gui2/?type=authors&mode=browse&sel=10025300" target="_blank">Szécsényi, Mária</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000069"> <a href="/gui2/?type=authors&mode=browse&sel=10000069" target="_blank">Burián, Katalin</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10029049"> <a href="/gui2/?type=authors&mode=browse&sel=10029049" target="_blank">Vályi, Péter</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011282"> <a href="/gui2/?type=authors&mode=browse&sel=10011282" target="_blank">Berkó, Szilvia</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1142773"> <a href="/gui2/?type=authors&mode=browse&sel=1142773" target="_blank">Pukánszky, Béla</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32337511" mtid="32337511" target="_blank">Physical–Chemical Aspects of the Preparation and Drug Release of Electrospun Scaffolds</a></div> <div class="pub-info"> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-volume">13</span> : <span class="journal-issue">10</span> <span class="page"> Paper: 1645 , 15 p. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/pharmaceutics13101645" target="_blank" href="https://doi.org/10.3390/pharmaceutics13101645"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000715619000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000715619000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117416168" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117416168"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34683939" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34683939&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/1999-4923/13/10/1645" target="_blank" href="https://www.mdpi.com/1999-4923/13/10/1645"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22742" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22742"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:32337511 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 1 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt: 7 | WoS/Scopus jelölt: 7 | DOI jelölt: 7 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
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<span class="authorAux-mtmt"> Kémiai tudományok, Polymer</span>)
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<span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Fizikai Kémia és Anyagtudományi Tanszék</span>
;
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<span class="author-name" mtid="10032093"><a
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<span class="authorAux-mtmt"> Gyógyszertechnológia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet</span>
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<span class="author-name" mtid="10025300"><a
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<span class="authorAux-mtmt"> növénybiológia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet</span>
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<span class="author-name" mtid="10000069"><a
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<span class="authorAux-mtmt"> orvosi mikrobiológia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet</span>
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<span class="authorAux-mtmt"> Parodontológia</span>)
</a>
</span>
<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orális Diagnosztikai Tanszék</span>
;
<span class="author-name" mtid="10011282"><a
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(<span class="authorship-author-name">Berkó Szilvia</span>
<span class="authorAux-mtmt"> Gyógyszertechnológia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet</span>
;
<span class="author-name" mtid="1142773"><a
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(<span class="authorship-author-name">Pukánszky Béla</span>
<span class="authorAux-mtmt"> polimerfizika</span>)
</a>
</span>
<span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Fizikai Kémia és Anyagtudományi Tanszék; <span title="Természettudományi Kutatóközpont">TTK</span>/Anyag- és Környezetkémiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Anyag- és Környezetkémiai Intézet">AKI</span>/Polimer Fizikai Kutatócsoport</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32337511" target="_blank">Physical–Chemical Aspects of the Preparation and Drug Release of Electrospun Scaffolds</a></div> <div> <span class="journal-title">PHARMACEUTICS</span>
<span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>:
<span class="journal-volume">13</span> <span class="journal-issue">10</span>
<span class="page">
Paper 1645.
15 p.
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<div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science SJR indikátor: Q1</div>
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span>
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<a target="_blank" href="/api/publication?cond=citations.related;eq;32337511&sort=publishedYear,desc&sort=title">
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 32337511</span>
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Forrás Idéző
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<div class="funder"> (BME IE-NAT TKP2020) Támogató: NKFIH </div>
<div class="lastModified">Utolsó módosítás: 2025.02.25. 23:44 Ladányi Gusztáv (MTMT API user, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Laboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest, H-1521, Hungary
Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, ELKH Eötvös Loránd Research Network, Budapest, H-1519, Hungary
Institute of Pharma...</pre>
</div></div>