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The endomorphin-2 (EM-2) and [D-Ala2, des-Leu5] enkephalin amide (DAPEA) are two linear opioid tetrapeptides agonists of MOR and MOR/DOR respectively. Herein, we investigated the influence of the incorporation of (R/S)-Agl in position 2 and 3 on the biological profile of the aforementioned products in vitro and in vivo. Receptor radiolabeled displacement and functional assays were used to measure in vitro the binding affinity and receptors activation of the novel analogues. The mouse tail flick and formalin tests allowed to observe their antinociceptive effect in vivo. Data revealed that peptide A2D was able to selectively bind and activate MOR with a potent antinociceptive effect after intracerebroventricular (i.c.v.) administration, performing better than the parent compounds EM-2 and DAPEA. 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Pain, 2, pp. 351-358", "listPosition" : 3, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359972, "link" : "/api/reference/24359972", "label" : "4. Szűcs, E., Stefanucci, A., Dimmito, M.P., Zádor, F., Pieretti, S., Zengin, G., Vécsei, L., Mollica, A., Discovery of kynurenines containing oligopeptides as potent opioid receptor agonists (2020) Biomolecules, 10, p. 284", "listPosition" : 4, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359971, "link" : "/api/reference/24359971", "label" : "5. Cheng, Y.-C., Prusoff, W.H., Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction (1973) Biochem. Pharmacol., 22, pp. 3099-3108", "listPosition" : 5, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359970, "link" : "/api/reference/24359970", "label" : "6. Mollica, A., Pelliccia, S., Famiglini, V., Stefanucci, A., Macedonio, G., Chievaroli, A., Orlando, G., Silvestri, R., Exploring the first rimonabant analog-opioid peptide hybrid compounds, as bivalent ligand for CB1 and opioid receptors (2017) J. Enz. Inhib. Med. Chem., 32, pp. 444-451", "listPosition" : 6, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359969, "link" : "/api/reference/24359969", "label" : "7. Keresztes, A., Szucs, M., Borics, A., Kovèr, K.E., Forrò, E., Fulop, F., Tomboly, C., Toth, G., New endomorphin analogues containing alicyclic b-amino acids: Influence on bioactive conformation and pharmacological profile (2008) J. Med. Chem., 51, pp. 4270-4279", "listPosition" : 7, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359968, "link" : "/api/reference/24359968", "label" : "8. Tymecka, D., Lipiński, P.F.J., Kosson, P., Misicka, A., β2-Homo-Amino acid scan of µ-selective opioid tetrapeptide TAPP (2020) Molecules, 25, p. 2461", "listPosition" : 8, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359967, "link" : "/api/reference/24359967", "label" : "9. Bondebjerg, J., Fuglsang, H., Rosendal Valeur, K., Pedersen, J., Nærum, L., Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors (2006) Bioorg. Med. Chem. Lett., 16, pp. 3614-3617", "listPosition" : 9, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359966, "link" : "/api/reference/24359966", "label" : "10. Mollica, A., Pinnen, F., Stefanucci, A., Feliciani, F., Campestre, C., Mannina, L., Sobolev, A.P., Hruby, V.J., (2012), pp. 3027-3035. , The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues, J. Med. Chem. 55", "listPosition" : 10, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359965, "link" : "/api/reference/24359965", "label" : "11. Freidinger, R.M., Design and Synthesis of Novel Bioactive Peptides and Peptidomimetics (2003) J. Med. Chem., 46, pp. 5553-5566", "listPosition" : 11, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359964, "link" : "/api/reference/24359964", "label" : "12. Lama, T., Campiglia, P., Carotenuto, A., Auriemma, L., Gomez-Monterrey, I., Novellino, E., Grieco, P., A novel route to synthesize Freidinger lactams by microwave irradiation (2005) J. Pept. Res., 66, pp. 231-235", "listPosition" : 12, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359963, "link" : "/api/reference/24359963", "label" : "13. Lee, P.J., Dunlap, B., Rich, D.H., Synthesis and immunosuppressive activities of conformationally restricted cyclosporin lactam analogues (1990) Int. J. Pept. Prot. Res., 35, pp. 481-494", "listPosition" : 13, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359962, "link" : "/api/reference/24359962", "label" : "14. Kumar, S., Wang, Q., Sasaki, N.A., Synthesis of conformationally constrained analogues of RGD tripeptide (2007) Tetrahedron, 63, pp. 2084-2092", "listPosition" : 14, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359961, "link" : "/api/reference/24359961", "label" : "15. Geranurimi, A., Cheng, C.W.H., Quiniou, C., Zhu, T., Hou, X., Rivera, J.C., St-Cyr, D.J., Lubell, W.D., Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands (2019) Front Chem., 7, p. 23", "listPosition" : 15, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359960, "link" : "/api/reference/24359960", "label" : "16. Shane, R., Wilk, S., Bondar, R.J., Modulation of endomorphin-2-induced analgesia by dipeptidyl peptides IV (1999) Brain Res., 815, p. 278", "listPosition" : 16, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359959, "link" : "/api/reference/24359959", "label" : "17. Xiaofeng, H., Ning, W., Weihua, R., Rui, W., Albert, C.S., Structure-activity relationship of endomorphins and their analogs (2001) Chin. Sci. Bull., 46, pp. 1096-1099", "listPosition" : 17, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359958, "link" : "/api/reference/24359958", "label" : "18. Yamazaki, M., Suzuki, T., Narita, M., Lipkowski, A.W., The opioid peptide biphalin induces less physical dependence than morphine (2001) Life Sci., 69, pp. 1023-1028", "listPosition" : 18, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359957, "link" : "/api/reference/24359957", "label" : "19. Feliciani, F., Pinnen, F., Stefanucci, A., Costante, R., Cacciatore, I., Lucente, G., Mollica, A., Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors (2013) Mini-Rev. Med. Chem., 13, pp. 11-33", "listPosition" : 19, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359956, "link" : "/api/reference/24359956", "label" : "20. (2017), Schrödinger Release 2017-3: Prime, Schrödinger, LLC, New York, NY", "listPosition" : 20, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359955, "link" : "/api/reference/24359955", "label" : "21. Stefanucci, A., Dimmito, M.P., Macedonio, G., Ciarlo, L., Pieretti, S., Novellino, E., Lei, W., Mollica, A., Potent, efficacious, and stable cyclic opioid peptides with long lasting antinociceptive effect after peripheral administration (2020) J. Med. Chem., 63, pp. 2673-2687", "listPosition" : 21, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359954, "link" : "/api/reference/24359954", "label" : "22. Jones, G., Willett, P., Glen, R.C., Leach, A.R., Taylor, R., Development and Validation of a Genetic Algorithm for Flexible Docking (1997) J. Mol. Biol., 267, pp. 727-748", "listPosition" : 22, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359953, "link" : "/api/reference/24359953", "label" : "23. Harder, E., Damm, W., Maple, J., Wu, C., Reboul, M., Xiang, J.Y., Wang, L., Friesner, R.A., OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins (2015) J. Chem. Theory Comput., 12, pp. 281-296", "listPosition" : 23, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359952, "link" : "/api/reference/24359952", "label" : "24. (2017), Schrödinger Release 2017-3: LigPrep, Schrödinger, LLC, New York, NY", "listPosition" : 24, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359951, "link" : "/api/reference/24359951", "label" : "25. (2017), Schrödinger Release 2017-3: Epik, Schrödinger, LLC, New York, NY", "listPosition" : 25, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359950, "link" : "/api/reference/24359950", "label" : "26. (2017), Schrödinger Release 2017-3: Protein Preparation Wizard, Schrödinger, LLC, New York, NY", "listPosition" : 26, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359949, "link" : "/api/reference/24359949", "label" : "27. Huang, W., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kobilka, B.K., Structural insights into µ-opioid receptor activation (2015) Nature, 524, pp. 315-321", "listPosition" : 27, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359948, "link" : "/api/reference/24359948", "label" : "28. Camarda, V., Calò, G., Chimeric G proteins in fluorimetric calcium assays: experience with opioid receptors (2013) Methods Mol. Biol., 937, pp. 293-306", "listPosition" : 28, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359947, "link" : "/api/reference/24359947", "label" : "29. Camarda, V., Fischetti, C., Anzellotti, N., Molinari, P., Ambrosio, C., Kostenis, E., Regoli, D., Calò, G., Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5 (2009) Naunyn Schmiedebergs Arch Pharmacol., 379, pp. 599-607", "listPosition" : 29, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359946, "link" : "/api/reference/24359946", "label" : "30. Traynor, J.R., Nahorski, S.R., Modulation by mu-opioid agonists of guanosine-5’-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells (1995) Mol. Pharmacol., 47, pp. 848-854", "listPosition" : 30, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359945, "link" : "/api/reference/24359945", "label" : "31. Sim, L.J., Selley, D.E., Childers, S.R., In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5’-[gamma-[35S]thio]-triphosphate binding (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 7242-7246", "listPosition" : 31, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359944, "link" : "/api/reference/24359944", "label" : "32. Guerrieri, E., Mallareddy, J.R., Tóth, G., Schmidhammer, H., Spetea, M., Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor (2015) ACS Chem. Neurosci., 6, pp. 456-463", "listPosition" : 32, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359943, "link" : "/api/reference/24359943", "label" : "33. Oktem, H.A., Moitra, J., Benyhe, S., Tóth, G., Lajtha, A., Borsodi, A., Opioid receptor labeling with the chloromethyl ketone derivative of [3H]Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) II: Covalent labeling of mu opioid binding site by 3H-Tyr-D-Ala-Gly-(Me)Phe chloromethyl ketone (1991) Life Sci., 48, pp. 1763-1768", "listPosition" : 33, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359942, "link" : "/api/reference/24359942", "label" : "34. Tömböly, C., Ballet, S., Feytens, D., Kövér, K.E., Borics, A., Lovas, S., Al-Khrasani, M., Tourwé, D., Endomorphin-2 with a β-Turn Backbone Constraint Retains the Potent µ-Opioid Receptor Agonist Properties (2008) J. Med. Chem., 51, pp. 173-177", "listPosition" : 34, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359941, "link" : "/api/reference/24359941", "label" : "35. Eguchi, M., Shen, R.Y., Shea, J.P., Lee, M.S., Kahn, M., Design, synthesis, and evaluation of opioid analogues with non-peptidic β-turn scaffold: Enkephalin and endomorphin mimetics (2002) J. Med. Chem., 45, pp. 1395-1398", "listPosition" : 35, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359940, "link" : "/api/reference/24359940", "label" : "36. Doi, M., Asano, A., Komura, E., Ueda, Y., The structure of an endomorphinanalogueincorporating1-aminocyclohexane-1-carboxylic acid for proline is similar to the β-turn of Leu-enkephalin (2002) Biochem. Biophys. Res. Commun., 297, pp. 138-142", "listPosition" : 36, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359939, "link" : "/api/reference/24359939", "label" : "37. Shimohigashi, Y., Costa, T., Chen, H.C., Rodbard, D., Dimeric tetrapeptide enkephalins display extraordinary selectivity for the opiate receptor (1982) Nature, 297, pp. 333-335", "listPosition" : 37, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359938, "link" : "/api/reference/24359938", "label" : "38. Aubry, A., Birlirakis, N., Sakarellos-Daitsiotis, M., Sakarellos, C., Marraud, M.J., A crystal molecular conformation of leucine-enkephalin related to the morphine molecule (1989) Biopolymers, 28, pp. 27-40", "listPosition" : 38, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359937, "link" : "/api/reference/24359937", "label" : "39. Blundell, T.L., Hearn, L., Tickle, I.J., Palmer, R.A., Morgan, B.A., Smith, G.D., Griffin, J.F., Crystal structure of [Leu5]encephalin (1979) Science, 205, p. 220", "listPosition" : 39, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359936, "link" : "/api/reference/24359936", "label" : "40. Blomberg, D., Kreye, P., Fowler, C., Brickmann, K., Kihlberg, J., Synthesis and biological evaluation of leucine enkephalin turn mimetics (2006) Org. Biomol. Chem., 4, pp. 416-423", "listPosition" : 40, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359935, "link" : "/api/reference/24359935", "label" : "41. Blomberg, D., Hedenström, M., Kreye, P., Sethson, I., Brickmann, K., Kihlberg, J., Synthesis and Conformational Studies of a β-Turn Mimetic Incorporated in Leu-enkephalin (2004) J. Org. Chem., 69, pp. 3500-3508", "listPosition" : 41, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359934, "link" : "/api/reference/24359934", "label" : "42. Sanfelice, D., Temussi, P.A., The conformation of enkephalin bound to its receptor: an “elusive goal” becoming reality (2014) Front. Mol. Biosci., 1, pp. 1-8", "listPosition" : 42, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359933, "link" : "/api/reference/24359933", "label" : "43. Stefanucci, A., Mosquera, J., Vázquez, E., Mascareñas, J.L., Novellino, E., Mollica, A., Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein (2015) ACS Medicinal Chem. Lett., 6, pp. 1220-1224", "listPosition" : 43, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359932, "link" : "/api/reference/24359932", "label" : "44. Stefanucci, A., Amato, J., Brancaccio, D., Pagano, B., Randazzo, A., Santoro, F., Mayol, L., Mollica, A., A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA (2021) Bioorganic Chem., 112, p. 112104836", "listPosition" : 44, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359931, "link" : "/api/reference/24359931", "label" : "45. Tyndall, J.D., Pfeiffer, B., Abbenante, G., Fairlie, D.P., Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure (2005) Chem Rev., 105, pp. 793-826. , PMID: 15755077", "listPosition" : 45, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359930, "link" : "/api/reference/24359930", "label" : "46. Wu, L., Mcelheny, D., Setnicka, V., Hilario, J., Keiderling, T.A., Role of different β-turns in β-hairpin conformation and stability studied by optical spectroscopy (2012) Proteins Struct. Funct. Bioinforma., 80, pp. 44-60", "listPosition" : 46, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359929, "link" : "/api/reference/24359929", "label" : "47. Wolfe, M.S., Dutta, D., Aube, J., Stereoselective synthesis of Freidinger lactams using oxaziridines derived from amino acids (1997) J. Org. Chem., 62, pp. 654-663", "listPosition" : 47, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359928, "link" : "/api/reference/24359928", "label" : "48. LeTiran, A., Stables, J.P., Kohn, H., (2001), pp. 2693-2708. , Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues, Bioorg. Med. Chem. 9", "listPosition" : 48, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359927, "link" : "/api/reference/24359927", "label" : "49. Sato, K., Nagai, U., Synthesis and antibiotic activity of a gramicidin S analogue containing bicyclic β-turn dipeptides (1986) J. Chem. Soc. Perkin Trans., 1, pp. 1231-1234", "listPosition" : 49, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359926, "link" : "/api/reference/24359926", "label" : "50. Nagai, U., Sato, K., Synthesis of a bicyclic dipeptide with the shape of β-turn central part (1985) Tetrahedron Lett., 26, pp. 647-650", "listPosition" : 50, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359925, "link" : "/api/reference/24359925", "label" : "51. Lubell, W.D., Blankenship, J.W., Fridkin, G., Kaul, R., , pp. 713-809. , “Peptides,” in: S.M. Weinreb (Ed.), Science of Synthesis, Thieme, Stuttgart, 2005", "listPosition" : 51, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359924, "link" : "/api/reference/24359924", "label" : "52. Freidinger, R.M., Veber, D.F., Perlow, D.S., Brooks, J.R., Saperstein, R., Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog (1980) Science, 210, pp. 656-658", "listPosition" : 52, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359923, "link" : "/api/reference/24359923", "label" : "53. Freidinger, R.M., Perlow, D.S., Veber, F., Protected lactam-bridged dipeptides for use as conformational constraints in peptides (1982) J. Org. Chem., 47, pp. 104-109", "listPosition" : 53, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359922, "link" : "/api/reference/24359922", "label" : "54. Liskamp, R.M., Rijkers, D.T., Kruijtzer, J.A., Kemmink, J., Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics (2011) Chembiochem, 12, pp. 1626-1653", "listPosition" : 54, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359921, "link" : "/api/reference/24359921", "label" : "55. Liu, J., Han, J., Izawa, K., Sato, T., White, S., Meanwell, N.A., Soloshonok, V.A., Cyclic tailor-made amino acids in the design of modern pharmaceuticals (2020) Eur. J. Med. Chem., 208", "listPosition" : 55, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359920, "link" : "/api/reference/24359920", "label" : "56. White, C., Yudin, A., Contemporary strategies for peptide macrocyclization (2011) Nature Chem, 3, pp. 509-524", "listPosition" : 56, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359919, "link" : "/api/reference/24359919", "label" : "57. Vu, Q.N., Young, R., Krishna, S.H., Gao, T., Huang, T., Tan, Y.S., Lau, Y.H., Cyclisation strategies for stabilising peptides with irregular conformations (2021) RSC Med. Chem.", "listPosition" : 57, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359918, "link" : "/api/reference/24359918", "label" : "58. Ding, Y., Ting, J.P., Liu, J., Al-Azzam, S., Pandya, P., Afshar, S., Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics (2020) Amino Acids, 52, pp. 1207-1226", "listPosition" : 58, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359917, "link" : "/api/reference/24359917", "label" : "59. Stefanucci, A., Pinnen, F., Feliciani, F., Cacciatore, I., Lucente, G., Mollica, A., Conformationally constrained histidines in the design of peptidomimetics: Strategies for the χ-space control (2011) Int. J. Mol. Sci., 12, pp. 2853-2890", "listPosition" : 59, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 24359916, "link" : "/api/reference/24359916", "label" : "60. Sharma, A., Kumar, A., Abdel Monaim, S.A.H., Jad, Y.E., El-Faham, A., de la Torre, B.G., Albericio, F., N-methylation in amino acids and peptides: Scope and limitations (2018) Biopolymers, 109", "listPosition" : 60, "published" : false, "snippet" : true } ], "hasCitationDuplums" : false, "userChangeableUntil" : "2021-10-19T06:14:54.947+0000", "directInstitutesForSort" : "Biokémiai Intézet (HRN SZBK)", "ownerAuthorCount" : 2, "ownerInstituteCount" : 7, "directInstituteCount" : 1, "authorCount" : 11, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/32334776", "label" : "Della Valle A. et al. Selective MOR activity of DAPEA and Endomorphin-2 analogues containing a (R)-γ-Freidinger lactam in position two. (2021) BIOORGANIC CHEMISTRY 0045-2068 1090-2120 115", "template" : "