Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke An Exploratory Analysis of the THALES Randomized Clinical Trial

Wang, Yongjun ✉; Pan, Yuesong; Li, Hao; Amarenco, Pierre; Denison, Hans; Evans, Scott R.; Himmelmann, Anders; James, Stefan; Birve, Filip; Ladenvall, Per; Molina, Carlos A.; Johnston, S. Claiborne ✉; Ameriso, Sebastian [Collaborator]; Gonzalez, Leonardo [Collaborator]; THALES Steering Comm Investigators [Collaborative Organization]; Ioli, Pablo [Collaborator]; Jure, Lorena [Collaborator]; Povedano, Guillermo [Collaborator]; Bruera, Guadalupe [Collaborator]; Herrera, Gustavo [Collaborator]; J Martin Artesi, Juan [Collaborator]; A Pujol Lereis, Virginia [Collaborator]; J Estol, Conrado [Collaborator]; Gomez Schneider, Maia [Collaborator]; Pigretti, Santiago [Collaborator]; Lipovestky, Fernando [Collaborator]; C Zurru, María [Collaborator]; Davis, Stephen [Collaborator]; Wong, Andrew [Collaborator]; Wijeratne, Tissa [Collaborator]; Sabet, Arman [Collaborator]; Lee, Andrew [Collaborator]; Thijs, Vincent [Collaborator]; Lemmens, Robin [Collaborator]; Yperzeele, Laetitia [Collaborator]; Vanhooren, Geert [Collaborator]; Vanacker, Peter [Collaborator]; Vansteenkiste, Iris [Collaborator]; Maqueda, Vicky [Collaborator]; Peeters, André [Collaborator]; Hasenbroekx, Marie-Christine [Collaborator]; Van Daele, Wendy [Collaborator]; De Pauw, Adinda [Collaborator]; Oedit, Regilio [Collaborator]; De Vooght, Wouter [Collaborator]; Desfontaines, Philippe [Collaborator]; Vandermeeren, Yves [Collaborator]; DA Dracoulakis, Marianna [Collaborator]; Bazan, Rodrigo [Collaborator]; M Pontes Neto, Octavio [Collaborator]; Dc Bezerra, Daniel [Collaborator]; C Marrone, Luiz [Collaborator]; A Kowacs, Pedro [Collaborator]; Hc Moro, Carla [Collaborator]; Co Macelino, Paulo [Collaborator]; Ta Pedatella, Marco [Collaborator]; Titianova, Ekaterina [Collaborator]; Staikov, Ivan [Collaborator]; Maslarov, Dimitar [Collaborator]; Petkov, Plamen [Collaborator]; Beleva, Tanya [Collaborator]; Kralev, Borislav [Collaborator]; Sotirov, Nikolay [Collaborator]; Hristov, Dimcho [Collaborator]; M Ivanova, Rumeliya [Collaborator]; V Mihailova, Margarita [Collaborator]; M Shuaib, Ashfaq [Collaborator]; Demchuk, Andrew [Collaborator]; Beaudry, Michel [Collaborator]; R Winder, Anthony [Collaborator]; Nayar, Sumiti [Collaborator]; Zheng, Huaguang [Collaborator]; Li, Shuya [Collaborator]; Zhao, Xingquan [Collaborator]; Wen, Guoqiang [Collaborator]; Dong, Xueshuang [Collaborator]; Li, Guozhong [Collaborator]; Zhang, Zhaohui [Collaborator]; Chen, Huisheng [Collaborator]; Wang, Dong [Collaborator]; Li, Xiaohong [Collaborator]; Wu, Yuncheng [Collaborator]; Zhang, Xu [Collaborator]; Zhang, Baorong [Collaborator]; Hong, Wenke [Collaborator]; Li, Xiaogang [Collaborator]; Wang, Lijuan [Collaborator]; Liu, Li [Collaborator]; Xu, Xiaolin [Collaborator]; Wang, Peifu [Collaborator]; Zheng, Weihong [Collaborator]; Zeng, Jinsheng [Collaborator]; Wang, Yukai [Collaborator]; Jia, Yan [Collaborator]; Li, Yongqiu [Collaborator]; Hu, Bo [Collaborator]; Shen, Wei [Collaborator]; Song, Zhi [Collaborator]; Hu, Zhiping [Collaborator]; Liu, Yunhai [Collaborator]; Ke, Kaifu [Collaborator]; Geng, Deqin [Collaborator]; Zhao, Shigang [Collaborator]; Zhu, Runxiu [Collaborator]; Qu, Qiumin [Collaborator]; Zhao, Xiuli [Collaborator]; Wan, Qi [Collaborator]; Yue, Yunhua [Collaborator]; Du, Huishan [Collaborator]; Zhang, Meiyun [Collaborator]; Wang, Yan [Collaborator]; Li, Dongfang [Collaborator]; Wang, Dongyu [Collaborator]; Li, Yongqiang [Collaborator]; Xie, Xufang [Collaborator]; Yu, Tingmin [Collaborator]; Liu, Qi [Collaborator]; Yang, Mingxiu [Collaborator]; Pan, Xiaoping [Collaborator]; Xu, Lijun [Collaborator]; Xu, Deen [Collaborator]; Li, Gang [Collaborator]; Xu, Anding [Collaborator]; Roubec, Martin [Collaborator]; Geier, Petr [Collaborator]; Vaclavik, Daniel [Collaborator]; Neumann, Jiri [Collaborator]; Bednarova, Jana [Collaborator]; Mikulik, Robert [Collaborator]; Hlinovsky, David [Collaborator]; Amarenco, Pierre [Collaborator]; Cordonnier, Charlotte [Collaborator]; Sibon, Igor [Collaborator]; Arquizan, Caroline [Collaborator]; Alamowitch, Sonia [Collaborator]; Lapergue, Bertrand [Collaborator]; Olivot, Jean-Marc [Collaborator]; Raposo, Nicolas [Collaborator]; Mahagne, Marie-Hélène [Collaborator]; Touze, Emmanuel [Collaborator]; Rodier, Gilles [Collaborator]; Vannier, Stéphane [Collaborator]; Samson, Yves [Collaborator]; Obadia, Michael [Collaborator]; Ellie, Emmanuel [Collaborator]; Guillon, Benoît [Collaborator]; Timsit, Serge [Collaborator]; Bejot, Yannick [Collaborator]; Wolff, Valérie [Collaborator]; Smadja, Didier [Collaborator]; Bagan-Triquenot, Aude [Collaborator]; Garnier, Pierre [Collaborator]; Ducrocq, Xavier [Collaborator]; Reiner, Peggy [Collaborator]; Moulin, Thierry [Collaborator]; Philippeau, Frédéric [Collaborator]; Pico, Fernando [Collaborator]; Richard, Sébastien [Collaborator]; Röther, Joachim [Collaborator]; Berrouschot, Jörg [Collaborator]; Soda, Hassan [Collaborator]; Pohlmann, Carsten [Collaborator]; Terborg, Christoph [Collaborator]; G Nabavi, Darius [Collaborator]; Dziewas, Rainer [Collaborator]; Köhrmann, Martin [Collaborator]; Glahn, Jörg [Collaborator]; Marquardt, Lars [Collaborator]; Kallmünzer, Bernd [Collaborator]; Weißenborn, Karin [Collaborator]; Ks Wong, Lawrence [Collaborator]; O-Y Soo, Yannie [Collaborator]; Li, Richard [Collaborator]; C Fong, Wing [Collaborator]; H Li, Siu [Collaborator]; Cheung, Raymond [Collaborator]; K Yip, Kin [Collaborator]; Wm Fok, Joshua [Collaborator]; Yp Fu, Michael [Collaborator]; Szegedi, Norbert [Collaborator]; Pozsegovits, Krisztián [Collaborator]; Valikovics, Attila [Collaborator]; Pánczél, Gyula [Collaborator]; Rózsa, Csilla [Rózsa, Csilla (neurológia), Collaborator]; Diószeghy, Péter [Collaborator]; Csányi, Attila [Collaborator]; Kerényi, Levente [Collaborator]; Nagy, Valéria [Collaborator]; Szapáry, László [Collaborator]; Bereczki, Dániel [Bereczki, Dániel (Stroke), Collaborator] Department of Neurology (SU / FM / C); Molnár, Sándor [Collaborator]; Timár, Gyula [Collaborator]; G Folyovich, András [Collaborator]; Sátori, Mária [Collaborator]; Vastagh, Ildikó [Collaborator]; K S, Praveen [Collaborator]; Kumar, Rajnish [Collaborator]; Prasad, Atul [Collaborator]; Sharma, Vikram [Collaborator]; Verma, Alok [Collaborator]; Basu, Indraneel [Collaborator]; Z Ansari, Abu [Collaborator]; Pamidimukkala, Vijaya [Collaborator]; Raghavendra, B S [Collaborator]; D Junewar, Vivek [Collaborator]; Singh, Sumit [Collaborator]; P Kulkarni, Advait [Collaborator]; Mv Srivastava, Padma [Collaborator]; Pramod, K [Collaborator]; G Ramteke, Sanjay [Collaborator]; Bansal, Jaideep [Collaborator]; Krishan, Kewal [Collaborator]; Kumar, Hrishikesh [Collaborator]; V Kashyap, Priyanka [Collaborator]; Tcr, Ramakrishnan [Collaborator]; R Adrasetty, Gopal [Collaborator]; Yeole, Amit [Collaborator]; B Baviskar, Rahul [Collaborator]; Agnelli, Giancarlo [Collaborator]; Toni, Danilo [Collaborator]; Ricci, Stefano [Collaborator]; Tassi, Rossana [Collaborator]; Micieli, Giuseppe [Collaborator]; Mancuso, Michelangelo [Collaborator]; Orlandi, Giovanni [Collaborator]; Chiti, Alberto [Collaborator]; Delodovici, Marialuisa [Collaborator]; Carimati, Federico [Collaborator]; De Vito, Alessandro [Collaborator]; Perini, Francesco [Collaborator]; Finocchi, Cinzia [Collaborator]; Tassinari, Tiziana [Collaborator]; Del Sette, Massimo [Collaborator]; Roveri, Luisa [Collaborator]; Zini, Andrea [Collaborator]; Bigliardi, Guido [Collaborator]; R Pezzella, Francesca [Collaborator]; Cupini, Letizia [Collaborator]; Adami, Alessandro [Collaborator]; Tomelleri, Giampaolo [Collaborator]; Zanferrari, Carla [Collaborator]; A Arauz Góngora, Angel [Collaborator]; López Ruíz, Minerva [Collaborator]; Ruíz Franco, Angelica [Collaborator]; Oj Chacon Romero, José [Collaborator]; Cruz Castillo, Fernando [Collaborator]; L Ruiz-Sandoval, Jose [Collaborator]; D López Tapia, Jesús [Collaborator]; A Castillo Vargas, Edgar [Collaborator]; F Gongora Rivera, Juan [Collaborator]; Rivera Martinez, Guillermo [Collaborator]; Villarreal Careaga, Jorge [Collaborator]; Custodio, Nilton [Collaborator]; G Pamo Reyna, Oscar [Collaborator]; A Castañeda, Cesar [Collaborator]; J Pretell, Edwin [Collaborator]; Najar, Nestor [Collaborator]; C Perez, Julio [Collaborator]; Cardoza, Luisa [Collaborator]; Chavez, Carlos [Collaborator]; Reyes, Maria [Collaborator]; Członkowska, Anna [Collaborator]; Fryze, Waldemar [Collaborator]; Sobolewski, Piotr [Collaborator]; Nowak, Ryszard [Collaborator]; Szkopek, Dorota [Collaborator]; Bąk, Zbigniew [Collaborator]; Brzozowski, Sławomir [Collaborator]; Brola, Waldemar [Collaborator]; Zalisz, Marek [Collaborator]; Rejdak, Konrad [Collaborator]; Bilik, Marta [Collaborator]; Fudala, Małgorzata [Collaborator]; Tutaj, Andrzej [Collaborator]; Lasek-Bal, Anetta [Collaborator]; Kochanowicz, Jan [Collaborator]; Karaszewski, Bartosz [Collaborator]; Berkowicz, Tomasz [Collaborator]; Zwiernik, Beata [Collaborator]; Różański, Dorota [Collaborator]; P Mejnartowicz, Jan [Collaborator]; Jurga, Szymon [Collaborator]; Rożniecki, Jacek [Collaborator]; Świat, Maciej [Collaborator]; A Bajenaru, Ovidiu [Collaborator]; A Panea, Cristina [Collaborator]; A Simu, Mihaela [Collaborator]; Balasa, Rodica [Collaborator]; L Cuciureanu, Dan [Collaborator]; O Popescu, Bogdan [Collaborator]; Sabau, Monica [Collaborator]; Roman-Filip, Corina [Collaborator]; Odnopozova, Liudmila [Collaborator]; Artyukov, Oleg [Collaborator]; Milto, Anna [Collaborator]; V Stakhovskaya, Liudmila [Collaborator]; Aksentiev, Sergei [Collaborator]; E Chuprina, Svetlana [Collaborator]; B Kuznetsova, Elena [Collaborator]; I Sholomov, Ilya [Collaborator]; Malygin, Alexander [Collaborator]; Mordvintseva, Elena [Collaborator]; Y Nilk, Rostislav [Collaborator]; Ershova, Inna [Collaborator]; Khasanova, Dina [Collaborator]; Akhmadeeva, Leila [Collaborator]; Iakupova, Aida [Collaborator]; A Drozdova, Ekaterina [Collaborator]; Tanashyan, Marine [Collaborator]; Pudov, Evgenij [Collaborator]; A Shpagina, Lybov [Collaborator]; Berns, Svetlana [Collaborator]; G Lenskaya, Liudmila [Collaborator]; Golikov, Konstantin [Collaborator]; V Kovalenko, Andrey [Collaborator]; Vasilieva, Elena [Collaborator]; Reznik, Elena [Collaborator]; Zykov, Mikhail [Collaborator]; Kovalchuk, Evgeniy [Collaborator]; Popov, Dmitry [Collaborator]; Belkin, Andrey [Collaborator]; Androfagina, Olga [Collaborator]; Lokshtanova, Tatyana [Collaborator]; V Melnikova, Elena [Collaborator]; Al-Senani, Fahmi [Collaborator]; Almansour, Nouf [Collaborator]; Alhussein, Fawaz [Collaborator]; Alkhathaami, Ali [Collaborator]; Alghamdi, Saeed [Collaborator]; Brozman, Miroslav [Collaborator]; Mikloskova, Marta [Collaborator]; Krastev, Georgi [Collaborator]; Serdahely, Vlastimil [Collaborator]; Kovacik, Michal [Collaborator]; Gurcik, Ladislav [Collaborator]; Dvorak, Miloslav [Collaborator]; Kurca, Egon [Collaborator]; Cimprichova, Andrea [Collaborator]; Kycina, Marian [Collaborator]; Zacharova, Erika [Collaborator]; Risnovsky, Richard [Collaborator]; Bae, Hee-Joon [Collaborator]; B Lee, Kyung [Collaborator]; Cho, Yong-Jin [Collaborator]; Park, Jong-Moo [Collaborator]; Kim, Joon-Tae [Collaborator]; Lee, Jun [Collaborator]; Cha, Jae-Kwan [Collaborator]; Sohn, Sung-Il [Collaborator]; Shin, Dong-Ick [Collaborator]; J Lee, Soo [Collaborator]; Lee, Byung-Chul [Collaborator]; C Choi, Jay [Collaborator]; S Park, Moo [Collaborator]; Chang, Dae-Il [Collaborator]; Rha, Joung-Ho [Collaborator]; M Sung, Sang [Collaborator]; Hwang, Yangha [Collaborator]; Molina Cateriano, Carlos [Collaborator]; Roquer González, Jaume [Collaborator]; Masjuan Vallejo, Jaime [Collaborator]; Gomis Cortina, Meritxell [Collaborator]; Moniche Álvarez, Francisco [Collaborator]; Á Gamero García, Miguel [Collaborator]; Pérez Sánchez, Soledad [Collaborator]; Purroy García, Francisco [Collaborator]; Trillo Senín, Santiago [Collaborator]; Segura Martín, Tomás [Collaborator]; Serena Leal, Joaquín [Collaborator]; Arenillas Lara, Juan [Collaborator]; Martí-Fàbregas, Joan [Collaborator]; Lago Martín, Aida [Collaborator]; Tejero Juste, Carlos [Collaborator]; Marta Moreno, Javier [Collaborator]; López Hernández, Nicolás [Collaborator]; Sjöblom, Lars [Collaborator]; C Laska, Ann [Collaborator]; Callander, Margarita [Collaborator]; Mooe, Thomas [Collaborator]; Karlsson, Jan-Erik [Collaborator]; O Romanitan, Mihaela [Collaborator]; Lindgren, Arne [Collaborator]; Ahmed, Niaz [Collaborator]; Cederin, Björn [Collaborator]; Kremer, Christine [Collaborator]; Lee, Tsong-Hai [Collaborator]; Jeng, Jiann-Shing [Collaborator]; Chen, Chih-Hung [Collaborator]; L Po, Helen [Collaborator]; Liou, Chia-Wei [Collaborator]; Lin, Huey-Juan [Collaborator]; Lin, Ruey-Tay [Collaborator]; Lin, Hsiu-Fen [Collaborator]; Lien, Li-Ming [Collaborator]; Chan, Lung [Collaborator]; Huang, Wei-Shih [Collaborator]; Huang, Wen-Yi [Collaborator]; Chen, Ta-Cheng [Collaborator]; Chen, Chin-I [Collaborator]; Chen, Po-Lin [Collaborator]; Yang, Chun-Pai [Collaborator]; Sun, Yu [Collaborator]; Charnnarong Suwanwela, Nijasri [Collaborator]; Chutinet, Aurauma [Collaborator]; Tantirittisak, Tasanee [Collaborator]; Muengtaweepongsa, Sombat [Collaborator]; Nilanont, Yongchai [Collaborator]; Tiamkao, Somsak [Collaborator]; Udommongkol, Chesda [Collaborator]; Jantararotai, Witoon [Collaborator]; Chongsuvivatwong, Tabtim [Collaborator]; Srisuwananukorn, Suwat [Collaborator]; Khaykhaew, Wasutha [Collaborator]; Paiboonpol, Supachai [Collaborator]; Limudomporn, Makorn [Collaborator]; Mayotarn, Saengduan [Collaborator]; Samintharapanya, Kanoksri [Collaborator]; Arayawichanon, Arkhom [Collaborator]; Thamangraksat, Thanoot [Collaborator]; Srimanee, Duangpol [Collaborator]; Chmyr, Galyna [Collaborator]; Tomakh, Nataliya [Collaborator]; Cherkez, Alla [Collaborator]; Moskovko, Sergii [Collaborator]; Nikonov, Vadym [Collaborator]; Shkrobot, Svitlana [Collaborator]; Shulga, Lyudmyla [Collaborator]; Hrebeniuk, Hanna [Collaborator]; Yavorska, Valentyna [Collaborator]; Lytvynenko, Nataliia [Collaborator]; Khavunka, Marta [Collaborator]; Kobets, Iryna [Collaborator]; Chemer, Nataliia [Collaborator]; Tashchuk, Ivanna [Collaborator]; Myronova, Olha [Collaborator]; H Nguyen, Thang [Collaborator]; V Vo, Tan [Collaborator]; T Tran, Thanh [Collaborator]; Tp Nguyen, Nga [Collaborator]; D Nguyen, Anh [Collaborator]; T Nguyen, Binh [Collaborator]; B Nguyen, Thang [Collaborator]; H Nguyen, Ngoc [Collaborator]; D Nguyen, Quang [Collaborator]; D Le, Nhan [Collaborator]; D Pham, Dai [Collaborator]