https://m2.mtmt.hu/ eng 2026-10-23 19:14 JournalArticle 32299171 ADMIN_APPROVED true 0 false 2026-10-21T19:28:12.768+0000 2025-05-19T13:55:24.253+0000 2021-10-07T13:11:08.694+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2026-06-11T10:16:23.325+0000 2026-06-11T10:16:23.325+0000 2024-02-27T10:07:10.480+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2024-02-27T13:43:09.077+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Molnar, Andrea Agnes Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study true true /api/journal/10011725 REVIEWED true false 10011725 false 10011725 true 1010-660X 1648-9144 Journal FOREIGN 57 9 935 935 9 2021 Background and Objectives: No data are available on whether the heritability of left ventricle (LV) systolic and diastolic parameters are independent of each other. Therefore, our aim was to assess the magnitude of common and independent genetic and environmental factors defining LV systolic and diastolic function. Materials and Methods: We analyzed 184 asymptomatic twins (65% female, mean age: 56 +/- 9 years). Transthoracic echocardiography was performed to measure LV systolic (global longitudinal and circumferential strain; basal and apical rotation) and diastolic (early diastolic velocity of mitral inflow and lateral mitral annulus tissue; deceleration time and early diastolic strain rate) parameters using conventional and speckle-tracking echocardiography. Genetic structural equation models were evaluated to quantify the proportion of common and specific genetic (Ac, As) and environmental factors (Ec, Es) contributing to the phenotypes. Results: LV systolic parameters had no common genetic or environmental heritability (Ac range: 0-0%; Ec range: 0-0%; As range: 57-77%; Es range: 24-43%). Diastolic LV parameters were mainly determined by common genetic and environmental effects (Ac range: 9-40%; Ec range: 11-49%; As range: 0-29%; Es range: 0-51%). Systolic parameters had no common genetic or environmental factors (Ac = 0%; Ec = 0%) with diastolic metrics. Conclusions: Systolic LV parameters have a strong genetic predisposition to any impact. They share no common genetic or environmental factors with each other or with diastolic parameters, indicating that they may deteriorate specifically to given effects. However, diastolic functional parameters are mainly affected by common environmental influences, suggesting that pathological conditions may deteriorate them equally. Estimation of the genetic and environmental influence and interdependence on systolic and diastolic LV function may help the understanding of the pathomechanism of different heart failure classification types. Funding 2008877 /api/funding/2008877 false true Funding 2008878 /api/funding/2008878 false true true 2021 true true true false true false GOLD 2026-10-21 true https://doi.org/10.3390/medicina57090935 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 Q2 false 10015399 false false false 2021-10-06T13:26:34.310+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Orvosi Képalkotó Klinika (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 11 50 4 12 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 98024897 /api/authorship/98024897 1 0.083333336 true false true Author 10015399 /api/author/10015399 Molnár Andrea Ágnes true 10015399 true Molnar Andrea Agnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024898 /api/authorship/98024898 2 0.083333336 false false false Author 10050627 /api/author/10050627 Kolossváry Márton József true 10050627 true Kolossvary Marton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024899 /api/authorship/98024899 3 0.083333336 false false false Author 10057511 /api/author/10057511 Lakatos Bálint true 10057511 true Lakatos Balint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024900 /api/authorship/98024900 4 0.083333336 false false false Author 10064500 /api/author/10064500 Tokodi Márton true 10064500 true Tokodi Marton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024901 /api/authorship/98024901 5 0.083333336 false false false Author 10023716 /api/author/10023716 Tárnoki Ádám Domonkos true 10023716 true Tarnoki Adam Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024902 /api/authorship/98024902 6 0.083333336 false false false Author 10023718 /api/author/10023718 Tárnoki Dávid László true 10023718 true Tarnoki David Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024903 /api/authorship/98024903 7 0.083333336 false false false Author 10035614 /api/author/10035614 Kovács Attila true 10035614 true Kovacs Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024904 /api/authorship/98024904 8 0.083333336 false false false Author 10045643 /api/author/10045643 Szilveszter Bálint true 10045643 true Szilveszter Balint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024905 /api/authorship/98024905 9 0.083333336 false false false Voros Szilard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024906 /api/authorship/98024906 10 0.083333336 false false false Author 10005335 /api/author/10005335 Jermendy György true 10005335 true Jermendy Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024907 /api/authorship/98024907 11 0.083333336 false false false Author 10019530 /api/author/10019530 Maurovich-Horvat Pál true 10019530 true Maurovich-Horvat Pal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98024908 /api/authorship/98024908 12 0.083333336 false true false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Bela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19575273 /api/publicationidentifier/19575273 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/medicina57090935 https://doi.org/10.3390/medicina57090935 false true PublicationIdentifier 19575274 /api/publicationidentifier/19575274 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000699582800001 https://www.webofscience.com/wos/woscc/full-record/000699582800001 false true PublicationIdentifier 19575277 /api/publicationidentifier/19575277 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85114711458 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85114711458 false true PublicationIdentifier 19575275 /api/publicationidentifier/19575275 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34577858 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34577858&dopt=Abstract false true Keyword 1009010 /api/keyword/1009010 true 1009010 true Keyword 1054667 /api/keyword/1054667 true 1054667 true Keyword 1187752 /api/keyword/1187752 true 1187752 true Keyword 1297643 /api/keyword/1297643 true 1297643 true Keyword 1547720 /api/keyword/1547720 true true SjrRating 11226041 /api/sjrrating/11226041 1154 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/32299171 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015399"><a href="/gui2/?type=authors&mode=browse&sel=10015399" target="_blank">Molnar Andrea Agnes ✉ (<span class="authorship-author-name">Molnár Andrea Ágnes</span> <span class="authorAux-mtmt"> kardiológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050627"><a href="/gui2/?type=authors&mode=browse&sel=10050627" target="_blank">Kolossvary Marton (<span class="authorship-author-name">Kolossváry Márton József</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057511"><a href="/gui2/?type=authors&mode=browse&sel=10057511" target="_blank">Lakatos Balint (<span class="authorship-author-name">Lakatos Bálint</span> <span class="authorAux-mtmt"> orvostudományok, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064500"><a href="/gui2/?type=authors&mode=browse&sel=10064500" target="_blank">Tokodi Marton (<span class="authorship-author-name">Tokodi Márton</span> <span class="authorAux-mtmt"> kardiológia, echocardiographia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023716"><a href="/gui2/?type=authors&mode=browse&sel=10023716" target="_blank">Tarnoki Adam Domonkos (<span class="authorship-author-name">Tárnoki Ádám Domonkos</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023718"><a href="/gui2/?type=authors&mode=browse&sel=10023718" target="_blank">Tarnoki David Laszlo (<span class="authorship-author-name">Tárnoki Dávid László</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035614"><a href="/gui2/?type=authors&mode=browse&sel=10035614" target="_blank">Kovacs Attila (<span class="authorship-author-name">Kovács Attila</span> <span class="authorAux-mtmt"> kardiológia, sportkardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045643"><a href="/gui2/?type=authors&mode=browse&sel=10045643" target="_blank">Szilveszter Balint (<span class="authorship-author-name">Szilveszter Bálint</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Voros Szilard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005335"><a href="/gui2/?type=authors&mode=browse&sel=10005335" target="_blank">Jermendy Gyorgy (<span class="authorship-author-name">Jermendy György</span> <span class="authorAux-mtmt"> Belgyógyászat, anyagcsere betegségek</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019530"><a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pal (<span class="authorship-author-name">Maurovich-Horvat Pál</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32299171" target="_blank">Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study</a></div> <div> <span class="journal-title">MEDICINA-LITHUANIA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1010-660X">1010-660X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1648-9144">1648-9144</a>)</span>: <span class="journal-volume">57</span> <span class="journal-issue">9</span> <span class="page"> Paper 935. 9 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/medicina57090935" target="_blank" href="https://doi.org/10.3390/medicina57090935"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000699582800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000699582800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85114711458" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85114711458"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34577858" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34577858&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32299171&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32299171</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology </div> <div class="notDuplums"><a target="_blank" href="/api/publication/32299171/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2025.05.19. 15:55 András Balázs (MTMT Központ_, admin) </div> <div class="lockedBy">Centrally managed 2024.02.27. 14:43 Éva Pécsi (MTMT Közp 2,3, admin) </div> </div></div>