Nemzeti szívprogram(NVKP_16-1–2016-0017) Támogató: NKFIH
Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató:
Innovációs és Technológiai Minisztérium
Background and Objectives: No data are available on whether the heritability of left
ventricle (LV) systolic and diastolic parameters are independent of each other. Therefore,
our aim was to assess the magnitude of common and independent genetic and environmental
factors defining LV systolic and diastolic function. Materials and Methods: We analyzed
184 asymptomatic twins (65% female, mean age: 56 +/- 9 years). Transthoracic echocardiography
was performed to measure LV systolic (global longitudinal and circumferential strain;
basal and apical rotation) and diastolic (early diastolic velocity of mitral inflow
and lateral mitral annulus tissue; deceleration time and early diastolic strain rate)
parameters using conventional and speckle-tracking echocardiography. Genetic structural
equation models were evaluated to quantify the proportion of common and specific genetic
(Ac, As) and environmental factors (Ec, Es) contributing to the phenotypes. Results:
LV systolic parameters had no common genetic or environmental heritability (Ac range:
0-0%; Ec range: 0-0%; As range: 57-77%; Es range: 24-43%). Diastolic LV parameters
were mainly determined by common genetic and environmental effects (Ac range: 9-40%;
Ec range: 11-49%; As range: 0-29%; Es range: 0-51%). Systolic parameters had no common
genetic or environmental factors (Ac = 0%; Ec = 0%) with diastolic metrics. Conclusions:
Systolic LV parameters have a strong genetic predisposition to any impact. They share
no common genetic or environmental factors with each other or with diastolic parameters,
indicating that they may deteriorate specifically to given effects. However, diastolic
functional parameters are mainly affected by common environmental influences, suggesting
that pathological conditions may deteriorate them equally. Estimation of the genetic
and environmental influence and interdependence on systolic and diastolic LV function
may help the understanding of the pathomechanism of different heart failure classification
types.
