https://m2.mtmt.hu/ eng 2026-09-21 17:55 JournalArticle 32298338 APPROVED true 0 false 2026-07-23T08:11:05.970+0000 2025-10-14T08:02:06.075+0000 2021-10-07T11:07:42.398+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-05-22T08:55:28.175+0000 2026-05-22T08:55:28.175+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Luo, Wenshu Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2 true true /api/journal/3547 REVIEWED true false 3547 false 3547 true 0027-8424 1091-6490 Journal FOREIGN 118 40 e2108239118 e2108239118 11 2021 Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain. 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2024 0 3 1 3 1 2025 0 0 0 0 0 2026 0 4 3 4 3 D1 A false 10027815,156,215 false false false 2021-10-06T12:16:27.083+0000 Celluláris Neurofarmakológia Kutatócsoport (HRN KOKI); Neuronális hálózatok kutatócsoport (PTE / SZKK); Szentágothai János Kutatóközpont (PTE); Élettani Intézet (PTE / ÁOK) 6 53 4 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 98013832 /api/authorship/98013832 1 0.05882353 true false false Luo Wenshu true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013833 /api/authorship/98013833 2 0.05882353 false false false Egger Matteo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013834 /api/authorship/98013834 3 0.059 false false false Author 203 /api/author/203 Domonkos Andor true 203 true Domonkos Andor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013835 /api/authorship/98013835 4 0.05882353 false false false Que Lin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013836 /api/authorship/98013836 5 0.05882353 false false false Lukacsovich David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013837 /api/authorship/98013837 6 0.05882353 false false false Cruz-Ochoa Natalia Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013838 /api/authorship/98013838 7 0.05882353 false false false Author 10071872 /api/author/10071872 Szőcs Szilárd true true Szőcs Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013839 /api/authorship/98013839 8 0.05882353 false false false Seng Charlotte true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013840 /api/authorship/98013840 9 0.059 false false false Author 156 /api/author/156 Arszovszki Antónia true 156 true Arszovszki Antónia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013841 /api/authorship/98013841 10 0.059 false false false Author 10040883 /api/author/10040883 Bodóné Sipos Eszter true 10040883 true Sipos Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013842 /api/authorship/98013842 11 0.05882353 false false false Amrein Irmgard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013843 /api/authorship/98013843 12 0.05882353 false false false Winterer Jochen true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013844 /api/authorship/98013844 13 0.05882353 false false false Lukacsovich Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013845 /api/authorship/98013845 14 0.05882353 false false false Author 215 /api/author/215 Szabadics János true 215 true Szabadics János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013846 /api/authorship/98013846 15 0.05882353 false false false Wolfer David P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013847 /api/authorship/98013847 16 0.059 false false false Author 10027815 /api/author/10027815 Varga Csaba true 10027815 true Varga Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 98013848 /api/authorship/98013848 17 0.059 false true true Földy Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19572793 /api/publicationidentifier/19572793 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551102 /api/mtarating/11551102 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519088 /api/mtarating/519088 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19088 true SjrRating 11184988 /api/sjrrating/11184988 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/32298338 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Luo Wenshu </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Egger Matteo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="203"><a href="/gui2/?type=authors&mode=browse&sel=203" target="_blank">Domonkos Andor (<span class="authorship-author-name">Domonkos Andor</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Que Lin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacsovich David </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cruz-Ochoa Natalia Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071872"><a href="/gui2/?type=authors&mode=browse&sel=10071872" target="_blank">Szőcs Szilárd (<span class="authorship-author-name">Szőcs Szilárd</span> <span class="authorAux-mtmt"> Orvos</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seng Charlotte </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="156"><a href="/gui2/?type=authors&mode=browse&sel=156" target="_blank">Arszovszki Antónia (<span class="authorship-author-name">Arszovszki Antónia</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040883"><a href="/gui2/?type=authors&mode=browse&sel=10040883" target="_blank">Sipos Eszter (<span class="authorship-author-name">Bodóné Sipos Eszter</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Amrein Irmgard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Winterer Jochen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacsovich Tamás </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="215"><a href="/gui2/?type=authors&mode=browse&sel=215" target="_blank">Szabadics János (<span class="authorship-author-name">Szabadics János</span> <span class="authorAux-mtmt"> Celluláris neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wolfer David P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027815"><a href="/gui2/?type=authors&mode=browse&sel=10027815" target="_blank">Varga Csaba (<span class="authorship-author-name">Varga Csaba</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Cortical microcircuits research group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Földy Csaba ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32298338" target="_blank">Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">118</span> <span class="journal-issue">40</span> <span class="page"> Paper e2108239118. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1073/pnas.2108239118" target="_blank" href="https://doi.org/10.1073/pnas.2108239118"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000705928000006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000705928000006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85116325391" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85116325391"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34599103" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34599103&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 6 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;11 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32298338&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32298338</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (EFOP-3.6.2.-16-2017-00008), (20765-3/2018/FEKUTSRAT) Funder: -, Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2025.10.14. 10:02 Márta Turek (KOKI admin 4) </div> </div></div>