https://m2.mtmt.hu/ hun 2026-09-22 13:03 JournalArticle 32290844 VALIDATED true Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United States Cited By :5 Export Date: 6 October 2023 CODEN: AJPPD Correspondence Address: Jones, S.P.; Diabetes and Obesity Center, United States; email: steven.p.jones@louisville.edu 0 false 2026-07-22T11:43:07.520+0000 2022-11-24T19:02:54.891+0000 2021-10-06T17:47:55.606+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-09-24T07:47:07.984+0000 2022-11-24T19:02:55.128+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Audam, Timothy N. Cardiac PANK1 Deletion Exacerbates Ventricular Dysfunction During Pressure Overload true true /api/journal/21227 REVIEWED true false 21227 false 21227 true 0363-6135 1522-1539 Journal FOREIGN 321 4 H784 H797 H784 14 2021 Coenzyme A (CoA) is an essential co-factor required for intermediary metabolism. Perturbations in homeostasis of CoA have been implicated in various pathologies; however, whether CoA homeostasis is changed and the extent to which CoA levels contribute to ventricular function and remodeling during pressure overload has not been explored. In this study, we sought to assess changes in CoA biosynthetic pathway during pressure overload and determine the impact of limiting CoA on cardiac function. We limited cardiac CoA levels by deleting the rate limiting enzyme in CoA biosynthesis, Pank1. We found that constitutive, cardiomyocyte-specific Pank1 deletion (cmPank1-/-) significantly reduced PANK1 mRNA, PANK1 protein, and CoA levels compared to Pank1 sufficient littermates (cmPank1+/+) but exerted no obvious deleterious impact on the mice at baseline. We then subjected both groups of mice to pressure overload-induced heart failure. Interestingly, there was more ventricular dilation in cmPank1-/- during pressure overload. To explore potential mechanisms contributing to this phenotype, we performed transcriptomic profiling, which suggested a role for Pank1 in regulating fibrotic and metabolic processes during pressure overload. Indeed, Pank1 deletion exacerbated cardiac fibrosis following pressure overload. Because we were interested in the possibility of early metabolic impacts in response to pressure overload, we performed untargeted metabolomics, which indicated significant changes to metabolites involved in fatty acid and ketone metabolism, among other pathways. Collectively, our study underscores the role of elevated CoA levels in supporting fatty acid and ketone body oxidation, which may be more important than CoA-driven, enzyme-independent acetylation in the failing heart. Funding 2008873 /api/funding/2008873 false true Funding 2008874 /api/funding/2008874 false true Funding 2008875 /api/funding/2008875 false true true true 2021 true true true false true false PAY 2026-07-22 false 16 0 16 8 0 16 16 16 16 16 16 8 8 8 8 0 16 8 16 8 0 1 1 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 4 1 4 1 2023 0 2 1 2 1 2024 0 2 1 2 1 2025 0 7 4 7 4 2026 0 1 1 1 1 Q1 false false false false 2021-11-09T08:45:14.191+0000 Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 4 32 2 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97962976 /api/authorship/97962976 1 0.05882353 true false false Audam Timothy N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962977 /api/authorship/97962977 2 0.05882353 false false false Howard Caitlin M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962978 /api/authorship/97962978 3 0.05882353 false false false Garrett Lauren F. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962979 /api/authorship/97962979 4 0.05882353 false false false Zheng Yi Wei true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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/api/authorship/97962985 10 0.059 false false false Author 10063814 /api/author/10063814 Herczeg Szilvia true 10063814 true Herczeg Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962986 /api/authorship/97962986 11 0.059 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962987 /api/authorship/97962987 12 0.059 false false false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Radovits Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962988 /api/authorship/97962988 13 0.05882353 false false false Uchida Shizuka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962989 /api/authorship/97962989 14 0.05882353 false false false Hill Bradford G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962990 /api/authorship/97962990 15 0.05882353 false false false Dassanayaka Sujith true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962991 /api/authorship/97962991 16 0.05882353 false false false Jackowski Suzanne true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97962992 /api/authorship/97962992 17 0.059 false true true Jones Steven P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19548726 /api/publicationidentifier/19548726 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.1152/ajpheart.00411.2021 https://doi.org/10.1152/ajpheart.00411.2021 false true PublicationIdentifier 20759607 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34533403 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34533403&dopt=Abstract true true SjrRating 11227937 /api/sjrrating/11227937 50 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/32290844 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Audam Timothy N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Howard Caitlin M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garrett Lauren F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zheng Yi Wei </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bradley James A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brittian Kenneth R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Frank Matthew W. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fulghum Kyle L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026455"><a href="/gui2/?type=authors&mode=browse&sel=10026455" target="_blank">Pólos Miklós (<span class="authorship-author-name">Pólos Miklós</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063814"><a href="/gui2/?type=authors&mode=browse&sel=10063814" target="_blank">Herczeg Szilvia (<span class="authorship-author-name">Herczeg Szilvia</span> <span class="authorAux-mtmt"> kardiológia, elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamás (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Uchida Shizuka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hill Bradford G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dassanayaka Sujith </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jackowski Suzanne </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jones Steven P. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32290844" target="_blank">Cardiac PANK1 Deletion Exacerbates Ventricular Dysfunction During Pressure Overload</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0363-6135">0363-6135</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1522-1539">1522-1539</a>)</span>: <span class="journal-volume">321</span> <span class="journal-issue">4</span> <span class="page"> pp H784-H797 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1152/ajpheart.00411.2021" target="_blank" href="https://doi.org/10.1152/ajpheart.00411.2021"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000760700300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000760700300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117931201" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117931201"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34533403" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34533403&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 16</span> | Független: 8 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 16 | Scopus jelölt:&nbsp;16 | WoS/Scopus jelölt:&nbsp;16 | DOI jelölt:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32290844&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32290844</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> National Research, Development and Innovation Office (NKFIH) of Hungary(K134939), National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 20:02 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United States Cited By :5 Export Date...</pre> </div></div>