https://m2.mtmt.hu/ hun 2026-09-21 22:46 JournalArticle 32246036 VALIDATED true Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany Diabetes Research Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom Department of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, Rome, Italy Department of Endocrinology, Federal Bureau of Medical and Social Expertise, Moscow, Russian Federation Department of Endocrinology, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation Zayed Centre for Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates Department of Diabetology, National Medical Academy for Postgraduate Education, Kiev, Ukraine National Institute of Endocrinology and Diabetology, Lubochna, Slovakia Faculty of Health Sciences, University of Ss. Cyril and Methodius in Trnava, Slovakia “N. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Carol Davila” Bucharest, Romania Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam Asklepios Klinik Birkenwerder, Birkenwerder, Germany Department of Endocrinology, Medical University - Sofia, Sofia, Bulgaria Department of Internal Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Neurology, Harvard Medical School, Boston, MA, United States Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Faculty of Biology, Medicine and Health, University of Manchester and Manchester University Foundation Trust, UK, Manchester, United Kingdom Cited By :10 Export Date: 20 December 2022 CODEN: DRCPE Correspondence Address: Ziegler, D.; Institute for Clinical Diabetology, Auf'm Hennekamp 65, Germany; email: dan.ziegler@ddz.de Chemicals/CAS: actovegin, 63748-11-8; benfotiamine, 22457-89-2; capsaicin, 404-86-4; desipramine, 50-47-5, 58-28-6; duloxetine, 116539-59-4, 136434-34-9, 959392-22-4; epalrestat, 82159-09-9; gabapentin, 60142-96-3; imipramine, 113-52-0, 50-49-7; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; nortriptyline, 72-69-5, 894-71-3; opiate, 53663-61-9, 8002-76-4, 8008-60-4; pregabalin, 148553-50-8; protein kinase C, 141436-78-4; protein kinase C theta; serine threonine protein kinase D2; tramadol, 27203-92-5, 36282-47-0; venlafaxine, 93413-69-5, 99300-78-4, 93413-44-6, 93413-45-7, 93413-46-8, 93413-47-9 Tradenames: Sudoscan 0 false 2026-08-27T10:44:41.219+0000 2023-06-27T09:09:06.968+0000 2021-09-28T06:52:43.557+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 2024-06-11T08:02:37.617+0000 2022-05-24T11:05:10.321+0000 true 10073049 Sóki Edina /api/admin/10073049 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Ziegler, Dan Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice International expert consensus recommendations true true /api/journal/1308 REVIEWED true false 1308 false 1308 true 0168-8227 1872-8227 Journal FOREIGN 186 109063 109063 23 2022 Diabetic sensorimotor polyneuropathy (DSPN) affects around one third of people with diabetes and accounts for considerable morbidity, increased risk of mortality, reduced quality of life, and increased health care costs resulting particularly from neuropathic pain and foot ulcers. Painful DSPN is encountered in 13-26% of diabetes patients, while up to 50% of patients with DSPN may be asymptomatic. Unfortunately, DSPN still remains inadequately diagnosed and treated. Herein we provide international expert consensus recommendations and algorithms for screening, diagnosis, and treatment of DSPN in clinical practice derived from a Delphi process. Typical neuropathic symptoms include pain, paresthesias, and numbness particularly in the feet and calves. Clinical diagnosis of DSPN is based on neuropathic symptoms and signs (deficits). Management of DSPN includes three cornerstones: 1.) lifestyle modification, optimal diabetes treatment aimed at near-normoglycemia, and multifactorial cardiovascular risk intervention, 2.) pathogenetically oriented pharmacotherapy (e.g. α-lipoic acid and benfotiamine), and 3.) symptomatic treatment of neuropathic pain including analgesic pharmacotherapy (antidepressants, anticonvulsants, opioids, capsaicin 8% patch and combinations, if required) and non-pharmacological options. Considering the individual risk profile, pain management should not only aim at pain relief, but also allow for improvement in quality of sleep, functionality, and general quality of life. true true 2021 true true true false true false GREEN 2026-08-27 true http://publicatio.bibl.u-szeged.hu/22527 186 0 186 152 11 185 181 149 164 175 175 141 141 152 34 0 186 152 186 152 0 4 4 Folyóiratcikk Journal Article 24 184 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb 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true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97696788 /api/authorship/97696788 15 0.067 false true false Jm Boulton Andrew true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19412118 /api/publicationidentifier/19412118 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.diabres.2021.109063 https://doi.org/10.1016/j.diabres.2021.109063 false true PublicationIdentifier 21226843 /api/publicationidentifier/21226843 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000803883000001 https://www.webofscience.com/wos/woscc/full-record/000803883000001 false true PublicationIdentifier 20836709 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Ziegler Dan ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tesfaye Solomon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spallone Vincenza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gurieva Irina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Al Kaabi Juma </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mankovsky Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Martinka Emil </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Radulian Gabriela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thy Nguyen Khue </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stirban Alin O </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tankova Tsvetalina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019187"><a href="/gui2/?type=authors&mode=browse&sel=10019187" target="_blank">Varkonyi Tamás (<span class="authorship-author-name">Várkonyi Tamás</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Freeman Roy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024012"><a href="/gui2/?type=authors&mode=browse&sel=10024012" target="_blank">Kempler Péter (<span class="authorship-author-name">Kempler Péter</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jm Boulton Andrew </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32246036" target="_blank">Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice : International expert consensus recommendations.</a></div> <div> <span class="journal-title">DIABETES RESEARCH AND CLINICAL PRACTICE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0168-8227">0168-8227</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1872-8227">1872-8227</a>)</span>: <span class="journal-volume">186</span> <span class="page"> Paper 109063. 23 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.diabres.2021.109063" target="_blank" href="https://doi.org/10.1016/j.diabres.2021.109063"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000803883000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000803883000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85120968476" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85120968476"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34547367" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34547367&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22527" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22527"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 186</span> | Független: 152 | Függő: 34 | Nem jelölt: 0 | WoS jelölt: 149 | Scopus jelölt:&nbsp;164 | WoS/Scopus jelölt:&nbsp;175 | DOI jelölt:&nbsp;181 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32246036&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32246036</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2023.06.27. 11:09 Aggod Zsuzsa (MTMT 2-3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany Diabetes Research Department, Sheffi...</pre> </div></div>