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The author is very grateful to Suk Keun Lee, Professor Emeritus of Gangneung-Wonju National University, for teaching the IP-HPLC experiment technique and for helping us greatly in the progress of the experiment.\nExport Date: 23 September 2021 \n Correspondence Address: Yang, H.J.; Department of Oral and Maxillofacial Surgery, South Korea; email: yanghoonjoo@snu.ac.kr \n Correspondence Address: Kim, S.M.; Department of Oral and Maxillofacial Surgery, South Korea; email: smin_kim@hanmail.net", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-10-27T10:01:12.012+0000", "lastModified" : "2021-09-23T11:46:04.751+0000", "created" : "2021-09-23T11:45:35.810+0000", "creator" : { "otype" : "Admin", "mtid" : 10022707, "link" : "/api/admin/10022707", "label" : "Najbauerné Bacsics Zsuzsanna (PTE ÁOK admin 5_inaktív)", "familyName" : "Najbauerné Bacsics", "givenName" : "Zsuzsanna", "published" : true, "oldId" : 10022707, "snippet" : true }, "lastDuplumOK" : 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"abstractText" : "Pentoxifylline (PTX) is a methylxanthine derivative that has been developed as an immunomodulatory agent and an improvement of microcirculation. Osteoradionecrosis (ORN) is a serious complication of radiation therapy due to hypovascularity. Coronavirus disease 2019 (COVID-19) has spread globally. Symptoms for this disease include self-limiting respiratory tract illness to severe pneumonia and acute respiratory distress. In this study, the effects of PTX on RAW 264.7 cells were investigated to reveal the possibility of PTX as a therapeutic agent for ORN and COVID-19. To reveal PTX effects at the cellular level, protein expression profiles were analyzed in the PTX-treated RAW 264.7 cells by using immunoprecipitation high-performance liquid chromatography (IP-HPLC). PTX-treated RAW 264.7 cells showed increases in immunity- and osteogenesis-related proteins and concurrent decreases in proliferation-, matrix inflammation-, and cellular apoptosis-related proteins expressions. The IP-HPLC results indicate that PTX plays immunomodulatory roles in RAW 264.7 cells by regulating anti-inflammation-, proliferation-, immunity-, apoptosis-, and osteogenesis-related proteins. 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