Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Lukoyanov, Nikolay; Watanabe, Hiroyuki; Carvalho, Liliana S.; Kononenko, Olga; Sarkisyan, Daniil; Zhang, Mengliang; Andersen, Marlene Storm; Lukoyanova, Elena A.; Galatenko, Vladimir; Tonevitsky, Alex; Bazov, Igor; Iakovleva, Tatiana; Schouenborg, Jens; Bakalkin, Georgy ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: ELIFE 2050-084X 10 Paper: e65247 , 33 p. 2021
  • SJR Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous): D1
Azonosítók
Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones beta-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while antagonists of the opioid and vasopressin receptors blocked hindlimb postural asymmetry in rats with brain injury. Thus, in addition to the well-established involvement of motor pathways descending from the brain to spinal circuits, the side-specific humoral signaling may also add to postural and reflex asymmetries seen after brain injury.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2021-12-08 05:32