https://m2.mtmt.hu/ hun 2026-09-23 07:49 JournalArticle 32218461 VALIDATED true Funding Agency and Grant Number: Boehringer Ingelheim; Eli Lilly Funding text: Supported by Boehringer Ingelheim and Eli Lilly. 0 false 2026-09-22T12:09:54.561+0000 2022-11-24T19:02:52.490+0000 2021-09-21T08:58:48.769+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2025-10-01T11:53:01.220+0000 2025-10-01T11:53:01.220+0000 2022-11-24T19:02:52.964+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Anker, Stefan D. Empagliflozin in Heart Failure with a Preserved Ejection Fraction true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 385 1451 1461 1451 11 2021 BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. CONCLUSIONS Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes. 2021 true true true false false NONE 2026-09-22 false 4192 0 4192 3812 38 4173 4111 3835 4029 4192 4192 3812 3812 3812 380 0 4192 3812 4192 3812 0 4 4 Folyóiratcikk Journal Article 24 4152 Könyvrészlet Chapter in Book 25 40 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb 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href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (41) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">EMPEROR Preserved Trial</span> </div> <div><a target="_blank" href="/api/publication/32218461?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32218461" target="_blank">Empagliflozin in Heart Failure with a Preserved Ejection Fraction</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">385</span> <span class="page"> pp 1451-1461 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2107038" target="_blank" href="https://doi.org/10.1056/NEJMoa2107038"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000691622000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000691622000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85114487957" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85114487957"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34449189" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34449189&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4,192</span> | Független: 3,812 | Függő: 380 | Nem jelölt: 0 | WoS jelölt: 3,835 | Scopus jelölt:&nbsp;4,029 | WoS/Scopus jelölt:&nbsp;4,192 | DOI jelölt:&nbsp;4,111 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32218461&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32218461</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/32218461/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 20:02 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Boehringer Ingelheim; Eli Lilly Funding text: Supported by Boehringer Ingelheim and Eli Lilly.</pre> </div></div>