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Correspondence Address: Venglovecz, V.; Department of Pharmacology and Pharmacotherapy, Hungary; email: venglovecz.viktoria@med.u-szeged.hu
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Altered esophageal ion transport mechanisms play a key role in inflammatory and cancerous diseases of the esophagus, but epithelial ion processes have been less studied in the esophagus because of the lack of a suitable experimental model. In this study, we generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs. EOs form a cell-filled structure with a diameter of 250-300 µm and generated from epithelial stem cells as shown by FACS analysis. Using conventional PCR and immunostaining, the presence of Slc26a6 Cl-/HCO3- anion exchanger (AE), Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), cystic fibrosis transmembrane conductance regulator (CFTR) and anoctamin 1 Cl- channels were detected in EOs. Microfluorimetric techniques revealed high NHE, AE, and NBC activities, whereas that of CFTR was relatively low. In addition, inhibition of CFTR led to functional interactions between the major acid-base transporters and CFTR. We conclude that EOs provide a relevant and suitable model system for studying the ion transport mechanisms of esophageal epithelial cells, and they can be also used as preclinical tools to assess the effectiveness of novel therapeutic compounds in esophageal diseases associated with altered ion transport processes.
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/api/publication/32204160
<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10069747"> <a href="/gui2/?type=authors&mode=browse&sel=10069747" target="_blank">Korsós, Marietta Margaréta</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10052685"> <a href="/gui2/?type=authors&mode=browse&sel=10052685" target="_blank">Bellák, Tamás</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10069860"> <a href="/gui2/?type=authors&mode=browse&sel=10069860" target="_blank">Becskeházi, Eszter</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10069720"> <a href="/gui2/?type=authors&mode=browse&sel=10069720" target="_blank">Gál, Eleonóra</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032057"> <a href="/gui2/?type=authors&mode=browse&sel=10032057" target="_blank">Veréb, Zoltán</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002629"> <a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi, Péter</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10022556"> <a href="/gui2/?type=authors&mode=browse&sel=10022556" target="_blank">Venglovecz, Viktória ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32204160" mtid="32204160" target="_blank">Mouse organoid culture is a suitable model to study esophageal ion transport mechanisms</a></div> <div class="pub-info"> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: CELL PHYSIOLOGY</span> <span class="journal-volume">321</span> : <span class="journal-issue">5</span> <span class="page"> pp. C798-C811. , 14 p. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1152/ajpcell.00295.2021" target="_blank" href="https://doi.org/10.1152/ajpcell.00295.2021"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000711464200004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000711464200004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85119035263" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85119035263"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34524930" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34524930&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22422" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22422"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:32204160 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10069747"><a
href="/gui2/?type=authors&mode=browse&sel=10069747" target="_blank">Korsós Marietta Margaréta
(<span class="authorship-author-name">Korsós Marietta Margaréta</span>
<span class="authorAux-mtmt"> molekuláris biológia</span>)
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<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Pharmacology and Pharmacotherapy</span>
;
<span class="author-name" mtid="10052685"><a
href="/gui2/?type=authors&mode=browse&sel=10052685" target="_blank">Bellák Tamás
(<span class="authorship-author-name">Bellák Tamás</span>
<span class="authorAux-mtmt"> idegtudomány</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Anatomy, Histology and Embryology</span>
;
<span class="author-name" mtid="10069860"><a
href="/gui2/?type=authors&mode=browse&sel=10069860" target="_blank">Becskeházi Eszter
(<span class="authorship-author-name">Becskeházi Eszter</span>
<span class="authorAux-mtmt"> Élettan és kórélettan</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Pharmacology and Pharmacotherapy</span>
;
<span class="author-name" mtid="10069720"><a
href="/gui2/?type=authors&mode=browse&sel=10069720" target="_blank">Gál Eleonóra
(<span class="authorship-author-name">Gál Eleonóra</span>
<span class="authorAux-mtmt"> pancreas</span>)
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<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Pharmacology and Pharmacotherapy</span>
;
<span class="author-name" mtid="10032057"><a
href="/gui2/?type=authors&mode=browse&sel=10032057" target="_blank">Veréb Zoltán
(<span class="authorship-author-name">Veréb Zoltán</span>
<span class="authorAux-mtmt"> molekuláris biológia, mikrobiológia</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Dermatology and Allergology</span>
;
<span class="author-name" mtid="10002629"><a
href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter
(<span class="authorship-author-name">Hegyi Péter</span>
<span class="authorAux-mtmt"> Gasztroenterológia</span>)
</a>
</span>
<span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/1st Department of Internal Medicine; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/<span title="Department of Internal Medicine">DIMedicine</span>/First Department of Internal Medicine; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span>
;
<span class="author-name" mtid="10022556"><a
href="/gui2/?type=authors&mode=browse&sel=10022556" target="_blank">Venglovecz Viktória ✉
(<span class="authorship-author-name">Venglovecz Viktória</span>
<span class="authorAux-mtmt"> Pankreász</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Pharmacology and Pharmacotherapy</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32204160" target="_blank">Mouse organoid culture is a suitable model to study esophageal ion transport mechanisms</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: CELL PHYSIOLOGY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0363-6143">0363-6143</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1522-1563">1522-1563</a>)</span>:
<span class="journal-volume">321</span> <span class="journal-issue">5</span>
<span class="page">
pp C798-C811
</span> <span class="year">(2021)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Language:
English
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<span class="identifiers">
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<a style="color:blue" title="000711464200004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000711464200004">
WoS
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<a style="color:blue" title="85119035263" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85119035263">
Scopus
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<a style="color:blue" title="34524930" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34524930&dopt=Abstract">
PubMed
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<a target="_blank" href="/api/publication?cond=citations.related;eq;32204160&sort=publishedYear,desc&sort=title">
Number of cited publications: 8
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<div class="mtid"><span class="long-pub-mtid">Publication: 32204160</span>
| <span class="status-data status-VALIDATED"> Validated
</span>
Core Citing
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( Article
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| <span class="pub-category">Scientific</span>
| <span class="publication-sourceOfData">kézi felvitel</span>
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<div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO </div>
<div class="lastModified">Last Modified: 2023.06.21. 09:31 Róbert Milánkovics (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 26 January 2024
CODEN: AJPCD
Correspondence Address: Venglovecz, V.; Department of Pharmacology and Pharmacotherapy, Hungary; email: venglovecz.viktoria@med.u-szeged.hu</pre>
</div></div>