https://m2.mtmt.hu/ eng 2026-10-25 09:48 JournalArticle 32197523 VALIDATED true Funding Agency and Grant Number: National Brain Research Program I, II [KTIA NAP 13-1-2013-0001, 2017-1.2.1-NKP-2017-00002]; Hungarian Scientific Research Fund 2019 of the National Research, Development and Innovation Office [PD-132652]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [bo_78_20_2020]; EU Joint Programme-Neurodegenerative Disease Research (JPND) project (National Research, Development and Innovation Office, Hungary) [2019-2.1.7-ERA-NET-2020-00006]; New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Found [UNKP-20-5] Funding text: Our research was supported by the National Brain Research Program I, II (KTIA NAP 13-1-2013-0001; 2017-1.2.1-NKP-2017-00002); Hungarian Scientific Research Fund 2019 of the National Research, Development and Innovation Office (PD-132652); Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (bo_78_20_2020); EU Joint Programme-Neurodegenerative Disease Research (JPND) project (National Research, Development and Innovation Office, Hungary, 2019-2.1.7-ERA-NET-2020-00006); New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Found (UNKP-20-5). 0 false 2026-10-21T17:04:43.589+0000 2026-09-16T08:57:33.349+0000 2021-09-14T12:00:41.256+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-09-16T08:57:29.310+0000 2026-09-16T08:57:29.310+0000 2026-09-16T08:57:33.537+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Werber, Tom The Association of Periodontitis and Alzheimer's Disease How to Hit Two Birds with One Stone true true /api/journal/10007054 REVIEWED true false 10007054 false 10007054 true 1387-2877 1875-8908 Journal FOREIGN 84 1 1 21 1 21 2021 Alzheimer's disease (AD) is the leading cause of cognitive impairment in the elderly. Recent evidence suggests that preventive interventional trials could significantly reduce the risk for development of dementia. Periodontitis is the most common dental disease characterized by chronic inflammation and loss of alveolar bone and perialveolar attachment of teeth. Growing number of studies propose a potential link between periodontitis and neurodegeneration. In the first part of the paper, we overview case-control studies analyzing the prevalence of periodontitis among AD patients and healthy controls. Second, we survey observational libraries and cross-sectional studies investigating the risk of cognitive decline in patients with periodontitis. Next, we describe the current view on the mechanism of periodontitis linked neural damage, highlighting bacterial invasion of neural tissue from dental plaques, and periodontitis induced systemic inflammation resulting in a neuroinflammatory process. Later, we summarize reports connecting the four most common periodontal pathogens to AD pathology. Finally, we provide a practical guide for further prevalence and interventional studies on the management of cognitively high-risk patients with and without periodontitis. In this section, we highlight strategies for risk control, patient information, dental evaluation, reporting protocol and dental procedures in the clinical management of patients with a risk for periodontitis and with diagnosed periodontitis. In conclusion, our review summarizes the current view on the association between AD and periodontitis and provides a research and intervention strategy for harmonized interventional trials and for further case-control or cross-sectional studies. 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(OMIII); Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Doktori Iskola (SE); Konzerváló Fogászati Klinika (SE / FOK); Neurológiai Klinika (SE / AOK / K); Általános Orvostudományi Kar (SE) 6 30 6 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97428976 /api/authorship/97428976 1 0.167 true false false Author 10084295 /api/author/10084295 Werber Tom true true Werber Tom true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97428977 /api/authorship/97428977 2 0.167 false false false Author 10040893 /api/author/10040893 Bata Zsófia true 10040893 true Bata Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97428978 /api/authorship/97428978 3 0.167 false false false Author 10044654 /api/author/10044654 Vasziné Szabó Enikő true 10044654 true Vaszine Eniko Szabo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97428979 /api/authorship/97428979 4 0.167 false false false Author 10083416 /api/author/10083416 Berente Dalida Borbála true true Berente Dalida Borbala true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97428980 /api/authorship/97428980 5 0.167 false false false Author 10000108 /api/author/10000108 Kamondi Anita true 10000108 true Kamondi Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97428981 /api/authorship/97428981 6 0.167 false true true Author 10055054 /api/author/10055054 Horváth András Attila true 10055054 true Horvath Andras Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19270470 /api/publicationidentifier/19270470 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3233/JAD-210491 https://doi.org/10.3233/JAD-210491 false true PublicationIdentifier 20297180 /api/publicationidentifier/20297180 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000722639900001 https://www.webofscience.com/wos/woscc/full-record/000722639900001 false true PublicationIdentifier 20232145 /api/publicationidentifier/20232145 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85118933308 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85118933308 false true PublicationIdentifier 19270469 /api/publicationidentifier/19270469 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34511500 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34511500&dopt=Abstract false true Classification 12181 /api/classification/12181 true true Keyword 11742 /api/keyword/11742 true 11742 true Keyword 17354 /api/keyword/17354 true 17354 true Keyword 17449 /api/keyword/17449 true 17449 true Keyword 1002283 /api/keyword/1002283 true 1002283 true Keyword 1011145 /api/keyword/1011145 true 1011145 true Keyword 1045179 /api/keyword/1045179 true 1045179 true Keyword 1122949 /api/keyword/1122949 true 1122949 true MtaRating 11435792 /api/mtarating/11435792 RatingType 10031 /api/ratingtype/10031 X. 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true SjrRating 11240575 /api/sjrrating/11240575 42 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3203 /api/classificationexternal/3203 true 3203 true Q1 DIRECT true true /api/publication/32197523 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10084295"><a href="/gui2/?type=authors&mode=browse&sel=10084295" target="_blank">Werber Tom (<span class="authorship-author-name">Werber Tom</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/Faculty of Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040893"><a href="/gui2/?type=authors&mode=browse&sel=10040893" target="_blank">Bata Zsofia (<span class="authorship-author-name">Bata Zsófia</span> <span class="authorAux-mtmt"> Fogorvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Conservative Dentistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044654"><a href="/gui2/?type=authors&mode=browse&sel=10044654" target="_blank">Vaszine Eniko Szabo (<span class="authorship-author-name">Vasziné Szabó Enikő</span> <span class="authorAux-mtmt"> Fogorvostudomány, neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Conservative Dentistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083416"><a href="/gui2/?type=authors&mode=browse&sel=10083416" target="_blank">Berente Dalida Borbala (<span class="authorship-author-name">Berente Dalida Borbála</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street); <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000108"><a href="/gui2/?type=authors&mode=browse&sel=10000108" target="_blank">Kamondi Anita (<span class="authorship-author-name">Kamondi Anita</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurology; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055054"><a href="/gui2/?type=authors&mode=browse&sel=10055054" target="_blank">Horvath Andras Attila ✉ (<span class="authorship-author-name">Horváth András Attila</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32197523" target="_blank">The Association of Periodontitis and Alzheimer's Disease : How to Hit Two Birds with One Stone.</a></div> <div> <span class="journal-title">JOURNAL OF ALZHEIMER'S DISEASE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1387-2877">1387-2877</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1875-8908">1875-8908</a>)</span>: <span class="journal-volume">84</span> <span class="journal-issue">1</span> <span class="page"> pp 1-21 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3233/JAD-210491" target="_blank" href="https://doi.org/10.3233/JAD-210491"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000722639900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000722639900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85118933308" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85118933308"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34511500" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34511500&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Clinical Psychology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 28</span> | Independent citation: 28 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 15 | Number of citations in Scopus:&nbsp;16 | WoS/Scopus assigned:&nbsp;17 | Number of citations with DOI:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32197523&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32197523</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> KTIA _NAP(13-1-2013-0001), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (PD-132652) Funder: NKFI, (bo_78_20_2020) Funder: Bolyai János Kutatási Ösztöndíj, (2019-2.1.7-ERA-NET-2020-00006) Funder: NKFI, (UNKP-20-5) </div> <div class="lastModified">Last Modified: 2026.09.16. 10:57 Zóra Kondor (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Brain Research Program I, II [KTIA NAP 13-1-2013-0001, 2017-1.2.1-NKP-2017-00002]; Hungarian Scientific Research Fund 2019 of the National Research, Development and Innovation Office [PD-132652]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [bo_78_20_2020]; EU Joint Programme-Neurodegenerative Disease Research (JPND) project (N...</pre> </div></div>