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Funding text: Work was funded via FPB School of Nursing start-up funds issued to GCO.
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O'Connell, Grant C.
Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers
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Background Detection of brain-specific miRNAs in the peripheral blood could serve as a surrogate marker of traumatic brain injury (TBI). Here, we systematically identified brain-enriched miRNAs, and tested their utility as TBI biomarkers in the acute phase of care. Methods Publically available microarray data generated from 29 postmortem human tissues were used to rank 1,364 miRNAs in terms of their degree of brain-specific expression. Levels of the top six ranked miRNAs were then prospectively measured in serum samples collected from 10 Patients with TBI at hospital admission, as well as from 10 controls. Results The top six miRNAs identified in our analysis (miR-124-3p, miR-219a-5p, miR-9-5p, miR-9-3p, miR-137, and miR-128-3p) were enriched 70 to 320-fold in brain relative to other tissues, and exhibited dramatically greater brain specificity compared to several miRNAs previously proposed as biomarkers. Furthermore, their levels were elevated in serum from patients with TBI compared to controls, and could collectively discriminate between groups with 90% sensitivity and 100% specificity. Interestingly, subsequent informatic pathway analysis revealed that their target transcripts were enriched for components of signaling pathways active in peripheral organs involved in common post-TBI complications. Conclusions The six candidate miRNAs identified in this preliminary study have promise as blood biomarkers of TBI, and could also be molecular contributors to systemic physiologic changes commonly observed post-injury.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > O'Connell, Grant C. ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Smothers, Christine G. </span> <span class="author-type"> </span> ; <span class="author-name" > Winkelman, Chris </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32196352" mtid="32196352" target="_blank">Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers</a></div> <div class="pub-info"> <span class="journal-title">BRAIN INJURY</span> <span class="journal-volume">34</span> : <span class="journal-issue">7</span> <span class="page"> pp. 965-974. , 10 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1080/02699052.2020.1764102" target="_blank" href="https://doi.org/10.1080/02699052.2020.1764102"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000542690600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000542690600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85087067652" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85087067652"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32497449" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32497449&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:32196352 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >O'Connell Grant C. ✉
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;
<span class="author-name" >Smothers Christine G.
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<span class="author-name" >Winkelman Chris
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32196352" target="_blank">Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers</a></div> <div> <span class="journal-title">BRAIN INJURY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0269-9052">0269-9052</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1362-301X">1362-301X</a>)</span>:
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 32196352</span>
| <span class="status-data status-APPROVED"> Nyilvános
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Idéző
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<div class="lastModified">Utolsó módosítás: 2022.01.25. 14:33 Milánkovics Róbert (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: FPB School of Nursing start-up funds issued to GCO
Funding text: Work was funded via FPB School of Nursing start-up funds issued to GCO.
Export Date: 14 September 2021
CODEN: BRAIE</pre>
</div></div>