https://m2.mtmt.hu/hun2024-03-29 07:05JournalArticle32196348ADMIN_APPROVEDtrueFunding Agency and Grant Number: Fonds de Recherche du Quebec-SanteFonds de la Recherche en Sante du Quebec [35334]
Funding text: Fonds de Recherche du Quebec-Sante (#35334).
Export Date: 14 September 2021
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REVIEWEDtruefalse33875false33875true1472-02051472-0213JournalFOREIGN38428528928552021Background Clinical assessment of patients with mild traumatic brain injury (mTBI) is challenging and overuse of head CT in the ED is a major problem. Several studies have attempted to reduce unnecessary head CTs following a mTBI by identifying new tools aiming to predict intracranial bleeding. Higher levels of S100B protein have been associated with intracranial haemorrhage following a mTBI in previous literature. The main objective of this study is to assess whether plasma S100B protein level is associated with clinically significant brain injury and could be used to reduce the number of head CT post-mTBI. Methods Study design: secondary analysis of a prospective multicentre cohort study conducted between 2013 and 2016 in five Canadian EDs. Inclusion criteria: non-hospitalised patients with mTBI with a GCS score of 13-15 in the ED and a blood sample drawn within 24 hours after the injury. Data collected: sociodemographic and clinical data were collected in the ED. S100B protein was analysed using ELISA. All CT scans were reviewed by a radiologist blinded to the biomarker results. Main outcome: the presence of clinically important brain injury. Results 476 patients were included. Mean age was 41 +/- 18 years old and 150 (31.5%) were women. Twenty-four (5.0%) patients had a clinically significant intracranial haemorrhage. Thirteen patients (2.7%) presented a non-clinically significant brain injury. A total of 37 (7.8%) brain injured patients were included in our study. S100B median value (Q1-Q3) was: 0.043 mu g/L (0.008-0.080) for patients with clinically important brain injury versus 0.039 mu g/L (0.023-0.059) for patients without clinically important brain injury. Sensitivity and specificity of the S100B protein level, if used alone to detect clinically important brain injury, were 16.7% (95% CI 4.7% to 37.4%) and 88.5% (95% CI 85.2% to 91.3%), respectively. Conclusion Plasma S100B protein level was not associated with clinically significant intracranial lesion in patients with mTBI.2021truetruetruefalsefalseNONE2024-01-31false00000000000011Q1falsefalsefalsefalse2021-09-13T09:45:32.568+00006340150trueLanguage10002
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Lecuyer, Julien Blais </span> <span class="author-type"> </span> ; <span class="author-name" > Mercier, Eric </span> <span class="author-type"> </span> ; <span class="author-name" > Tardif, Pier-Alexandre </span> <span class="author-type"> </span> ; <span class="author-name" > Archambault, Patrick M. </span> <span class="author-type"> </span> ; <span class="author-name" > Chauny, Jean-Marc </span> <span class="author-type"> </span> ; <span class="author-name" > Berthelot, Simon </span> <span class="author-type"> </span> ; <span class="author-name" > Frenette, Jerome </span> <span class="author-type"> </span> ; <span class="author-name" > Perry, Jeff </span> <span class="author-type"> </span> ; <span class="author-name" > Stiell, Ian </span> <span class="author-type"> </span> ; <span class="author-name" > Emond, Marcel </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32196348" mtid="32196348" target="_blank">S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study</a></div> <div class="pub-info"> <span class="journal-title">EMERGENCY MEDICINE JOURNAL</span> <span class="journal-volume">38</span> : <span class="journal-issue">4</span> <span class="page"> pp. 285-289. , 5 p. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1136/emermed-2020-209583" target="_blank" href="https://doi.org/10.1136/emermed-2020-209583"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000631868900008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000631868900008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85098160996" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85098160996"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33355233" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33355233&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:32196348 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Lecuyer Julien Blais
</span>
;
<span class="author-name" >Mercier Eric
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;
<span class="author-name" >Tardif Pier-Alexandre
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;
<span class="author-name" >Archambault Patrick M.
</span>
;
<span class="author-name" >Chauny Jean-Marc
</span>
;
<span class="author-name" >Berthelot Simon
</span>
;
<span class="author-name" >Frenette Jerome
</span>
;
<span class="author-name" >Perry Jeff
</span>
;
<span class="author-name" >Stiell Ian
</span>
;
<span class="author-name" >Emond Marcel
</span>
;
<span class="author-name" >Lee Jacques
</span>
;
<span class="author-name" >Lang Eddy
</span>
;
<span class="author-name" >McRae Andrew
</span>
;
<span class="author-name" >Boucher Valerie
</span>
;
<span class="author-name" >Le Sage Natalie
</span>
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</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32196348" target="_blank">S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study</a></div> <div> <span class="journal-title">EMERGENCY MEDICINE JOURNAL</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1472-0205">1472-0205</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1472-0213">1472-0213</a>)</span>:
<span class="journal-volume">38</span> <span class="journal-issue">4</span>
<span class="page">
pp 285-289
</span> <span class="year">(2021)</span>
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Angol
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Idézett közlemények száma: 1
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 32196348</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
</span>
Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
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| <span class="pub-category">Tudományos</span>
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<div class="lastModified">Utolsó módosítás: 2021.09.14. 11:45 Milánkovics Róbert (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Fonds de Recherche du Quebec-SanteFonds de la Recherche en Sante du Quebec [35334]
Funding text: Fonds de Recherche du Quebec-Sante (#35334).
Export Date: 14 September 2021
CODEN: EMJMB</pre>
</div></div>