https://m2.mtmt.hu/ eng 2026-04-15 19:04 JournalArticle 32196282 APPROVED true 0 false 2026-04-15T06:56:46.939+0000 2023-09-19T19:10:09.112+0000 2021-09-14T08:35:48.336+0000 true 10058707 Horváth László /api/author/10058707 Author László Horváth (Gyógyszerészet) true 10058707 2026-03-20T14:53:43.838+0000 2026-03-20T14:53:43.838+0000 Admin 10003134 /api/admin/10003134 György Wolf (MTMT Központi admin) Wolf György true 10003134 true 2026-04-15T06:50:12.368+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Héja, Máté true true /api/journal/10020902 REVIEWED FRONTIERS IN NEUROLOGY 1664-2295 1664-2295 true false 10020902 false 10020902 true 1664-2295 1664-2295 Journal FOREIGN 12 721337 721337 2021 Objectives: This retrospective single-center study aimed to investigate the risk factors, outcomes and complication rates in patients older vs. younger than 80 years treated with intravenous alteplase. Methods: Data of 1,253 thrombolysed patients were analyzed between January 1, 2004 and August 31, 2016. Vascular risk factors, stroke severity based on the NIHSS score, functional outcome using modified Rankin Scale (mRS), mortality and symptomatic intracerebral hemorrhage (SICH) were compared between two subgroups (<80 and >= 80 years). Results: 1,125 patients were included, 199 (17.6%) among them were aged over 80 years, majority (63.3%) were female (p < 0.00001). Mean age was 68.2 +/- 12.4 years, i.e., 64.7 +/- 10.8 years and 84.3 +/- 3.4 years in the younger and the older groups, respectively (p < 0.001). Atrial fibrillation and pre-stroke anticoagulation among patients over 80 years was more likely (p < 0.0005 and p = 0.02, respectively). NIHSS scores on admission and at 24 h were higher in elderly patients (p < 0.0001). ASPECT score at 24 h was less favorable in elderly patients (p = 0.007) and was associated with worse outcome. At 3 months, 59.8% of the patients from the older group had an unfavorable outcome (p < 0.0001), however 34.7% had independent outcome. The one-year- survival was significantly worse in the older group (p < 0.0001). The incidence of SICH was lower among older patients. In a logistic regression model, atrial fibrillation, heart failure, diabetes mellitus and smoking were proven as a significant independent risk factors for worse outcome. Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age. true 2021 true true true false true false GOLD 2026-04-15 true https://doi.org/10.3389/fneur.2021.721337 17 0 16 14 3 16 16 14 12 14 14 12 12 14 3 0 17 14 16 14 0 5 5 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 1 1 1 2021 0 0 0 0 0 2022 0 3 3 3 3 2023 0 5 3 5 3 2024 0 4 3 4 3 2025 0 3 3 3 3 2026 0 1 1 1 1 Q1 false 10038837,10039291,10002463,10058707 false false false 2021-09-15T12:43:53.322+0000 Gyógyszerfelügyelet és Gyógyszergazdálkodási Ta... (DE / GYTK); Neurológiai Klinika (DE / KK); Neurológiai Tanszék (DE / ÁOK); Politikatudományi és Szociológiai Intézet (DE / BTK) 5 17 4 5 0 true 10003134 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 97422972 /api/authorship/97422972 Héja, Máté [Héja, Máté (neurológia), author] Neurológiai Klinika (UD / KK) 1 0.2 true false false Author 10087526 /api/author/10087526 Máté Héja (neurológia) Héja Máté true true Héja Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 97422973 /api/authorship/97422973 Fekete, István [Fekete, István (Idegbetegségek, n...), author] Department of Neurology (UD) 2 0.2 false false false Author 10002463 /api/author/10002463 István Fekete (Idegbetegségek, neurológia) Fekete István true 10002463 true Fekete István true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 97422974 /api/authorship/97422974 Horváth, László [Horváth, László (Gyógyszerészet), author] Gyógyszerfelügyelet és Gyógyszergazdálkodási Ta... (UD) 3 0.2 false false false Author 10058707 /api/author/10058707 László Horváth (Gyógyszerészet) Horváth László true 10058707 true Horváth László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 97422975 /api/authorship/97422975 Márton, Sándor [Márton, Sándor József (alkalmazott stati...), author] Institute of Political Science and Sociology (UD) 4 0.2 false false false Author 10039291 /api/author/10039291 Sándor József Márton (alkalmazott statisztika, társadalomtudományok módszertan) Márton Sándor József true 10039291 true Márton Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 97422976 /api/authorship/97422976 Fekete, Klára Edit ✉ [Fekete, Klára (neurológia, klini...), author] Department of Neurology (UD) 5 0.2 false true true Author 10038837 /api/author/10038837 Klára Fekete (neurológia, klinikai neurofiziologia) Fekete Klára true 10038837 true Fekete Klára Edit true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 19267239 /api/publicationidentifier/19267239 DOI: 10.3389/fneur.2021.721337 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fneur.2021.721337 https://doi.org/10.3389/fneur.2021.721337 false true PublicationIdentifier 20065424 /api/publicationidentifier/20065424 WoS: 000703262300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000703262300001 https://www.webofscience.com/wos/woscc/full-record/000703262300001 false true PublicationIdentifier 20113123 /api/publicationidentifier/20113123 DEA: 321785 PlainSource 38 /api/publicationsource/38 DEA PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true DEA http://hdl.handle.net/2437/@@@ true true 38 true IDENTICAL 321785 http://hdl.handle.net/2437/321785 false true PublicationIdentifier 20113121 /api/publicationidentifier/20113121 Scopus: 85115841847 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85115841847 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85115841847 false true PublicationIdentifier 20113156 /api/publicationidentifier/20113156 PubMed: 34589048 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34589048 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34589048&dopt=Abstract false true PublicationIdentifier 20710393 /api/publicationidentifier/20710393 Egyéb URL: https://www.frontiersin.org/articles/10.3389/fneur.2021.721337/full PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.frontiersin.org/articles/10.3389/fneur.2021.721337/full https://www.frontiersin.org/articles/10.3389/fneur.2021.721337/full false true Classification 12322 /api/classification/12322 Clinical neurology true true Classification 12215 /api/classification/12215 Clinical medicine true true Keyword 15489 /api/keyword/15489 thrombolysis true 15489 true Keyword 17807 /api/keyword/17807 ischemic stroke true 17807 true Keyword 1020507 /api/keyword/1020507 outcome true 1020507 true Keyword 1041567 /api/keyword/1041567 elderly true 1041567 true Keyword 1597410 /api/keyword/1597410 Symptomatic intracerebral hemorrhage true true SjrRating 11231087 /api/sjrrating/11231087 sjr:Q1 (2021) Scopus - Neurology (clinical) FRONTIERS IN NEUROLOGY 1664-2295 92 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 Scopus - Neurology (clinical) true 2728 true Q1 DIRECT true true Reference 23071015 /api/reference/23071015 1. 2019: Stroke Collaborators. 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(2021) FRONTIERS IN NEUROLOGY 1664-2295 1664-2295 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10087526"><a href="/gui2/?type=authors&mode=browse&sel=10087526" target="_blank">Héja Máté (<span class="authorship-author-name">Héja Máté</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Klinikai Központ">KK</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002463"><a href="/gui2/?type=authors&mode=browse&sel=10002463" target="_blank">Fekete István (<span class="authorship-author-name">Fekete István</span> <span class="authorAux-mtmt"> Idegbetegségek, neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058707"><a href="/gui2/?type=authors&mode=browse&sel=10058707" target="_blank">Horváth László (<span class="authorship-author-name">Horváth László</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Pharmacy">Faculty of Pharmacy</span>/Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039291"><a href="/gui2/?type=authors&mode=browse&sel=10039291" target="_blank">Márton Sándor (<span class="authorship-author-name">Márton Sándor József</span> <span class="authorAux-mtmt"> alkalmazott statisztika, társadalomtudományok m...</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Arts">Faculty of Arts</span>/Institute of Political Science and Sociology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038837"><a href="/gui2/?type=authors&mode=browse&sel=10038837" target="_blank">Fekete Klára Edit ✉ (<span class="authorship-author-name">Fekete Klára</span> <span class="authorAux-mtmt"> neurológia, klinikai neurofiziologia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32196282" target="_blank">Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients–A “Real World Scenario”</a></div> <div> <span class="journal-title">FRONTIERS IN NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2295">1664-2295</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2295">1664-2295</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper 721337. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fneur.2021.721337" target="_blank" href="https://doi.org/10.3389/fneur.2021.721337"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000703262300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000703262300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="321785" target="_blank" href="http://hdl.handle.net/2437/321785"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85115841847" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85115841847"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34589048" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34589048&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.frontiersin.org/articles/10.3389/fneur.2021.721337/full" target="_blank" href="https://www.frontiersin.org/articles/10.3389/fneur.2021.721337/full"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neurology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 17</span> | Independent citation: 14 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32196282&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32196282</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2023.09.19. 21:10 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2026.04.15. 08:50 György Wolf (MTMT Központi admin) </div> </div></div>