https://m2.mtmt.hu/ eng 2026-09-21 03:49 JournalArticle 32187933 VALIDATED true 0 false 2026-08-12T09:11:16.941+0000 2024-06-18T20:37:36.726+0000 2021-09-10T06:48:49.871+0000 true 10030581 Kovács Ervin /api/author/10030581 Author true 10030581 2025-10-28T13:02:33.595+0000 2025-10-28T13:02:33.595+0000 2022-08-19T10:33:50.220+0000 true 10019966 Tóth Henrietta /api/admin/10019966 Admin true 10019966 Admin 10013962 /api/admin/10013962 Vasvari Lilian true 10013962 true 2025-02-15T15:12:20.615+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csomos, Attila A comprehensive study of the Ca2+ ion binding of fluorescently labelled BAPTA analogues true true /api/journal/28331 REVIEWED true false 28331 false 28331 true 1434-193X 1099-0690 Journal FOREIGN 2021 37 5248 5261 5248 17 2021 Since its development, the ionophore BAPTA (1,2?bis(2?aminophenoxy)-ethane?N,N,N?,N??tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as ?linker?). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the length of the linker, the number of O atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca 2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications. Funding 2007763 /api/funding/2007763 false true Funding 2007764 /api/funding/2007764 false true Funding 2007765 /api/funding/2007765 false true Funding 2007766 /api/funding/2007766 false true true true 2021 true true true false true false GOLD 2026-08-12 true https://doi.org/10.1002/ejoc.202100948 18 0 15 10 5 16 17 14 15 15 15 10 10 13 5 0 18 13 15 10 0 1 1 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 2 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 3 1 3 1 2024 0 6 4 6 4 2025 0 7 6 7 6 2026 0 1 1 1 1 Q2 false 10080505 false false false 2021-10-26T07:54:52.451+0000 Anyag- és Környezetkémiai Intézet (TTK); Femtonics Kutató és Fejlesztő Korlátolt Felelős...; Információs Technológiai és Bionikai Kar (PPKE); Korszerű Anyagok és Intelligens Technológiák Fe... (ME / K); Neuronhálózat és Dendritikus Aktivitás Kutatócs... (HRN KOKI); Orvosi Vegytani Intézet (SZTE / SZAOK); Polimer Kémiai Kutatócsoport (HRN TTK / AKI); Szerves Vegytani Intézet (SE / GYTK); Szervetlen és Analitikai Kémiai Tanszék (SZTE / TTIK / KI) 9 72 9 9 0 true 10013962 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97385983 /api/authorship/97385983 1 0.111 true false false Author 10068523 /api/author/10068523 Csomos Attila true true Csomos Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385984 /api/authorship/97385984 2 0.11111111 false false false Author 10080505 /api/author/10080505 Kontra Bence true true Kontra Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385985 /api/authorship/97385985 3 0.111 false false false Author 10002894 /api/author/10002894 Jancsó Attila true 10002894 true Jancsó Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385986 /api/authorship/97385986 4 0.111 false false false Author 10002987 /api/author/10002987 Galbács Gábor true 10002987 true Galbács Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385987 /api/authorship/97385987 5 0.111 false false false Author 10029095 /api/author/10029095 Deme Ruth true 10029095 true Deme Ruth true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385988 /api/authorship/97385988 6 0.111 false false false Author 10021901 /api/author/10021901 Kele Zoltán true 10021901 true Kele Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97385989 /api/authorship/97385989 7 0.111 false false false Author 10012926 /api/author/10012926 Rózsa J. 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<span class="author-name" mtid="10080505"><a href="/gui2/?type=authors&mode=browse&sel=10080505" target="_blank">Kontra Bence (<span class="authorship-author-name">Kontra Bence</span> <span class="authorAux-mtmt"> Szerves Kémia</span>) </a> </span> <span class="author-affil">Femtonics Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002894"><a href="/gui2/?type=authors&mode=browse&sel=10002894" target="_blank">Jancsó Attila (<span class="authorship-author-name">Jancsó Attila</span> <span class="authorAux-mtmt"> Bioszervetlen kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Inorganic and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002987"><a href="/gui2/?type=authors&mode=browse&sel=10002987" target="_blank">Galbács Gábor (<span class="authorship-author-name">Galbács Gábor</span> <span class="authorAux-mtmt"> analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Inorganic and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029095"><a href="/gui2/?type=authors&mode=browse&sel=10029095" target="_blank">Deme Ruth (<span class="authorship-author-name">Deme Ruth</span> <span class="authorAux-mtmt"> Szerves-és gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Organic Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021901"><a href="/gui2/?type=authors&mode=browse&sel=10021901" target="_blank">Kele Zoltán (<span class="authorship-author-name">Kele Zoltán</span> <span class="authorAux-mtmt"> Kémiai analitika, proteomika</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rózsa Balázs József (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030581"><a href="/gui2/?type=authors&mode=browse&sel=10030581" target="_blank">Kovács Ervin ✉ (<span class="authorship-author-name">Kovács Ervin</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Materials and Environmental Chemistry; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Materials and Environmental Chemistry">IMEC</span>/Polymer Chemistry; Femtonics Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042935"><a href="/gui2/?type=authors&mode=browse&sel=10042935" target="_blank">Mucsi Zoltán ✉ (<span class="authorship-author-name">Mucsi Zoltán</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="University of Miskolc">UM</span>/<span title="Karon kívüli szervezeti egységek">K</span>/Korszerű Anyagok és Intelligens Technológiák Felsőoktatási és Ipari Együttműködési Központ; Femtonics Ltd.</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32187933" target="_blank">A comprehensive study of the Ca2+ ion binding of fluorescently labelled BAPTA analogues</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF ORGANIC CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1434-193X">1434-193X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1099-0690">1099-0690</a>)</span>: <span class="journal-volume">2021</span> <span class="journal-issue">37</span> <span class="page"> pp 5248-5261 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/ejoc.202100948" target="_blank" href="https://doi.org/10.1002/ejoc.202100948"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000706986500018" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000706986500018"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="150482" target="_blank" href="https://real.mtak.hu/150482"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117084808" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117084808"> Scopus </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="23156" target="_blank" href="http://publicatio.bibl.u-szeged.hu/23156"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 13 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;15 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32187933&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32187933</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (2018-1.3.1-VKE-2018-00032), (OTKA PD128612) Funder: NRDIO, (BO 21/799) Funder: Bolyai János Kutatási Ösztöndíj, (2018-1.1.2-KFI-2018-00097) </div> <div class="lastModified">Last Modified: 2024.06.18. 22:37 Évi Nemec (MTMT Központi 3, admin) </div> <div class="lockedBy">Centrally managed 2025.02.15. 16:12 Lilian Vasvari (MTMT Központ, admin) </div> </div></div>