{ "labelLang" : "hun", "responseDate" : "2024-03-29 16:12", "content" : { "otype" : "JournalArticle", "mtid" : 32186825, "status" : "APPROVED", "published" : true, "comment" : "Funding Agency and Grant Number: U.S. Department of DefenseUnited States Department of Defense [WH81XWH-10-1-0623, WH81XWH-14-2-0018]; NIH NINDSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [K23 NS101036]\n Funding text: We are grateful to the U.S. Department of Defense grants WH81XWH-10-1-0623 and WH81XWH-14-2-0018 for generous support. Dr. Ruchira M. Jha was supported by NIH NINDS K23 NS101036 grant.\nSafar Center for Resuscitation Research, Department of Critical Care Medicine Anesthesiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Departments of Neurology Neurobiology and Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States \n Department of Neurosciences, University of Messina, Messina, Italy \n Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Bruce W. 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Carter Department of Veterans Affairs Medical Center, Miami, FL, United States \n Department of Neurological Surgery, Brain Trauma Research Center Anesthesiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Brain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States \n Program for Neurotrauma, Neuroproteomics and Biomarkers Research, Department of Emergency Medicine, McKnight Brin Institute, University of Florida, Gainesville, FL, United States \n Center for Innovative Research, Center for Proteomics and Biomarkers Research, Banyan Biomarkers, Inc., Alachua, FL, United States \n Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, United States \n Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, United States \n Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, United States \n Departments of Pediatrics Anesthesiology and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Cited By :4 \n Export Date: 13 September 2021 \n CODEN: JNEUE \n Correspondence Address: Kochanek, P.M.; Safar Center for Resuscitation Research, 4401 Penn Avenue, United States; email: kochanekpm@pitt.edu\nExport Date: 14 September 2021 \n CODEN: JNEUE\nSafar Center for Resuscitation Research, Department of Critical Care Medicine Anesthesiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Departments of Neurology Neurobiology and Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States \n Department of Neurosciences, University of Messina, Messina, Italy \n Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, United States \n Department of Neurological Surgery, Brain Trauma Research Center Anesthesiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Brain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States \n Program for Neurotrauma, Neuroproteomics and Biomarkers Research, Department of Emergency Medicine, McKnight Brin Institute, University of Florida, Gainesville, FL, United States \n Center for Innovative Research, Center for Proteomics and Biomarkers Research, Banyan Biomarkers, Inc., Alachua, FL, United States \n Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, United States \n Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, United States \n Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, United States \n Departments of Pediatrics Anesthesiology and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States \n Cited By :4 \n Export Date: 17 September 2021 \n CODEN: JNEUE \n Correspondence Address: Kochanek, P.M.; Safar Center for Resuscitation Research, 4401 Penn Avenue, United States; email: kochanekpm@pitt.edu", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-08-11T09:42:25.076+0000", "lastModified" : "2022-01-25T13:44:48.507+0000", "created" : "2021-09-09T12:03:12.796+0000", "creator" : { "otype" : "Admin", "mtid" : 10022707, "link" : "/api/admin/10022707", "label" : "Najbauerné Bacsics Zsuzsanna (PTE ÁOK admin 5)", "familyName" : "Najbauerné Bacsics", "givenName" : "Zsuzsanna", "published" : true, "oldId" : 10022707, "snippet" : true }, "lastDuplumSearch" : "2024-02-06T13:30:39.159+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Jha, Ruchira M.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 97380223, "link" : "/api/authorship/97380223", "label" : "Jha, Ruchira M.", "listPosition" : 1, "share" : 0.05882353, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Jha", "givenName" : "Ruchira M.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 97380224, "link" : "/api/authorship/97380224", "label" : "Mondello, Stefania", "listPosition" : 2, "share" : 0.05882353, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mondello", "givenName" : "Stefania", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 97380225, "link" : "/api/authorship/97380225", "label" : "Bramlett, Helen M.", "listPosition" : 3, "share" : 0.05882353, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Bramlett", "givenName" : "Helen M.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 97380226, "link" : "/api/authorship/97380226", "label" : "Dixon, C. 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"linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "33203303", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33203303&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 2712, "link" : "/api/journal/2712", "label" : "JOURNAL OF NEUROTRAUMA 0897-7151 1557-9042", "pIssn" : "0897-7151", "eIssn" : "1557-9042", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 2712, "snippet" : true }, "volume" : "38", "issue" : "5", "firstPage" : "628", "lastPage" : "645", "firstPageOrInternalIdForSort" : "628", "pageLength" : 18, "publishedYear" : 2021, "abstractText" : "Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (FPI; n = 45), controlled cortical impact (CCI; n = 30), or penetrating ballistic-like brain injury (PBBI; n = 36). Efficacy of GLY treatment (10-mu g/kg intraperitoneal loading dose at 10 min post-injury, followed by a continuous 7-day subcutaneous infusion [0.2 mu g/h]) on motor, cognitive, neuropathological, and biomarker outcomes was assessed across models. GLY improved motor outcome versus vehicle in FPI (cylinder task, p < 0.05) and CCI (beam balance, p < 0.05; beam walk, p < 0.05). In FPI, GLY did not benefit any other outcome, whereas in CCI, it reduced 21-day lesion volume versus vehicle (p < 0.05). On Morris water maze testing in CCI, GLY worsened performance on hidden platform latency testing versus sham (p < 0.05), but not versus TBI vehicle. In PBBI, GLY did not improve any outcome. Blood levels of glial fibrillary acidic protein and ubiquitin carboxyl terminal hydrolase-1 at 24 h did not show significant treatment-induced changes. In summary, GLY showed the greatest benefit in CCI, with positive effects on motor and neuropathological outcomes. GLY is the second-highest-scoring agent overall tested by OBTT and the only drug to reduce lesion volume after CCI. Our findings suggest that leveraging the use of a TBI model-based phenotype to guide treatment (i.e., GLY in contusion) might represent a strategic choice to accelerate drug development in clinical trials and, ultimately, achieve precision medicine in TBI.", "keywords" : [ { "otype" : "Keyword", "mtid" : 17576, "link" : "/api/keyword/17576", "label" : "DOUBLE-BLIND", "published" : true, "oldId" : 17576, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1007893, "link" : "/api/keyword/1007893", "label" : "Fluid percussion injury", "published" : true, "oldId" : 1007893, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1009903, "link" : "/api/keyword/1009903", "label" : "RAT MODEL", "published" : true, "oldId" : 1009903, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1069943, "link" : "/api/keyword/1069943", "label" : "contusion", "published" : true, "oldId" : 1069943, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1070841, "link" : "/api/keyword/1070841", "label" : "Glyburide", "published" : true, "oldId" : 1070841, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1116335, "link" : "/api/keyword/1116335", "label" : "REACTIVE ASTROCYTES", "published" : true, "oldId" : 1116335, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1172435, "link" : "/api/keyword/1172435", "label" : "Controlled cortical impact", "published" : true, "oldId" : 1172435, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1493338, "link" : "/api/keyword/1493338", "label" : "Clinical Neurology", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1496196, "link" : "/api/keyword/1496196", "label" : "NONSELECTIVE CATION CHANNEL", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1511472, "link" : "/api/keyword/1511472", "label" : "Critical Care Medicine", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1516673, "link" : "/api/keyword/1516673", "label" : "sulfonylurea receptor 1", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1554523, "link" : "/api/keyword/1554523", "label" : "rat", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1594726, "link" : "/api/keyword/1594726", "label" : "Cerebral edema", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1594726, "link" : "/api/keyword/1594726", "label" : "Cerebral edema", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1601655, "link" : "/api/keyword/1601655", "label" : "CONSORTIUM", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1619354, "link" : "/api/keyword/1619354", "label" : "Cellular edema", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1650811, "link" : "/api/keyword/1650811", "label" : "penetrating ballistic-like brain injury", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2347242, "link" : "/api/keyword/2347242", "label" : "HEMORRHAGIC PROGRESSION", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2347243, "link" : "/api/keyword/2347243", "label" : "INTRAVENOUS GLYBURIDE", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2021, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-08-11", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 5, "citedCount" : 5, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11231056, "link" : "/api/sjrrating/11231056", "label" : "sjr:Q1 (2021) Scopus - Neurology (clinical) JOURNAL OF NEUROTRAUMA 0897-7151 1557-9042", "listPos" : 62, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2728, "link" : "/api/classificationexternal/2728", "label" : "Scopus - Neurology (clinical)", "published" : true, "oldId" : 2728, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2021-12-08T13:08:22.231+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 8, "ownerInstituteCount" : 45, "directInstituteCount" : 0, "authorCount" : 17, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/32186825", "label" : "Jha Ruchira M. et al. 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