{ "labelLang" : "hun", "responseDate" : "2024-03-19 05:55", "content" : { "otype" : "JournalArticle", "mtid" : 3218309, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: Italian Ministry of Health [GR-2009-1596220]; Italian Ministry of University [RBFR124FEN]; Federico II-STAR grant; National Institute of Health (NIH) [USA 1R01HL118455-01A1]; Centers of Excellence of Genomic Science (CEGS) [1P50HG004233]; European Foundation for the Study of Diabetes (EFSD) New Horizons Collaborative Research Initiative from European Association for the Study of Diabetes (EASD); European Cooperation in Science and Technology (COST EUROS); European Research Council Advanced Grant (CardioEpigen) [294609]; Associazione Italiana per la Ricerca sul Cancro; Italian Ministry of Health; CARIPLO Foundation; National Research, Development, and Innovation Office [OTKA K 109737, OTKA ANN 107803, NVKP 16-1-2016-0017]; European Research Council (ERC) grant [311549]; VICI award from The Netherlands Organization for Scientific Research (NWO) [918-156-47]; ERC grant (Angiolnc); Leducq foundation grant (MIRVAD); Netherlands Organization for Health Research and Development (ZonMW Veni) [91612147]; Netherlands Heart Foundation [2013T056]; Deutsche Forschungsgemeinschaft (DFG Research Unit) [FOR 2149]; National Research Council; Duke-National University Singapore Medical School; National Medical Research Council National Heart Centre Singapore Collaborative Centre Grant; British Heart Foundation [FS/10/039/28270]; Rosetrees Trust; National Institute for Health Research University College London Hospitals Biomedical Research Centre, UK; ERC Grant (Longheart); Leducq Fondation grant (MIRVAD); Italian Ministry of Research and Education; European Research Council (ERC) [311549] Funding Source: European Research Council (ERC); British Heart Foundation [RG/16/14/32397, FS/13/2/29892, CH/16/3/32406] Funding Source: researchfish\n Funding text: This work was supported by the Italian Ministry of Health (GR-2009-1596220), by the Italian Ministry of University (RBFR124FEN), and by the Federico II-STAR grant (junior principal investigator) to C.P.; National Institute of Health (NIH), USA 1R01HL118455-01A1 and Centers of Excellence of Genomic Science (CEGS) 1P50HG004233 to A.L.B.; European Foundation for the Study of Diabetes (EFSD) New Horizons Collaborative Research Initiative from European Association for the Study of Diabetes (EASD) and European Cooperation in Science and Technology (COST EUROS) to R.S. and P.F.; European Research Council Advanced Grant (CardioEpigen, # 294609), Associazione Italiana per la Ricerca sul Cancro, the Italian Ministry of Health and the National Research Council, Italian Ministry of Research and Education, and the CARIPLO Foundation to G.C.; National Research, Development, and Innovation Office, (OTKA K 109737, OTKA ANN 107803, NVKP 16-1-2016-0017) to P.F.; European Research Council (ERC) grant 311549 and a VICI award 918-156-47 from The Netherlands Organization for Scientific Research (NWO) to L.D.W.; ERC grant (Angiolnc) and Leducq foundation grant (MIRVAD) to S.D.; the Netherlands Organization for Health Research and Development (ZonMW Veni 91612147) and Netherlands Heart Foundation (Dekker 2013T056) grants to L.V.L., and the Deutsche Forschungsgemeinschaft (DFG Research Unit FOR 2149) to F.B.E. 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Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signaling networks activated in the ischemic/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischemia, putting it in the context of the human \"diseasome\".Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. 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