https://m2.mtmt.hu/ hun 2026-05-31 03:02 JournalArticle 3217842 APPROVED true 0 2018-01-19T08:38:36.000+0000 false 3217842 2026-05-27T09:22:51.512+0000 2024-11-28T14:34:51.752+0000 2017-05-04T07:02:19.000+0000 true 10012397 Mezősi Emese /api/author/10012397 Author true 10012397 2025-09-19T08:27:01.784+0000 2025-09-19T08:27:01.784+0000 2019-01-12T15:32:38.562+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10013962 /api/admin/10013962 Vasvari Lilian true 10013962 true 2025-01-23T17:25:20.589+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Lonn, EM Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 374 21 2009 2020 2009 12 2016 BACKGROUND: Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its role in persons at intermediate risk and with lower blood pressure is unclear. METHODS: In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years. RESULTS: The mean blood pressure of the participants at baseline was 138.1/81.9 mm Hg; the decrease in blood pressure was 6.0/3.0 mm Hg greater in the active-treatment group than in the placebo group. The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.79 to 1.10; P=0.40); the second coprimary outcome occurred in 312 participants (4.9%) and 328 participants (5.2%), respectively (hazard ratio, 0.95; 95% CI, 0.81 to 1.11; P=0.51). In one of the three prespecified hypothesis-based subgroups, participants in the subgroup for the upper third of systolic blood pressure (>143.5 mm Hg) who were in the active-treatment group had significantly lower rates of the first and second coprimary outcomes than those in the placebo group; effects were neutral in the middle and lower thirds (P=0.02 and P=0.009, respectively, for trend in the two outcomes). CONCLUSIONS: Therapy with candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day was not associated with a lower rate of major cardiovascular events than placebo among persons at intermediate risk who did not have cardiovascular disease. (Funded by the Canadian Institutes of Health Research and AstraZeneca; ClinicalTrials.gov number, NCT00468923.). 2017 (Mezősi Emese (Endokrinológia); 2017.05.04. 09:00:57) true true true false true false GOLD 2026-05-27 true https://doi.org/10.1056/NEJMoa1600175 true 10022754 Milánkovics Róbert /api/admin/10022754 Admin true 10022754 600 0 600 534 4 599 558 540 573 600 600 534 534 534 66 0 600 534 600 534 0 3 3 Folyóiratcikk Journal Article 24 590 Könyvrészlet Chapter in Book 25 9 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 77 67 77 67 2017 0 149 132 149 132 2018 0 115 105 115 105 2019 0 79 67 79 67 2020 0 40 35 40 35 2021 0 46 38 46 38 2022 0 38 37 38 37 2023 0 19 18 19 18 2024 0 16 14 16 14 2025 0 16 16 16 16 2026 0 5 5 5 5 D1 false false false false 2018-01-19T08:38:36.000+0000 2017-05-04T07:13:56.000+0000 III. 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D1 DIRECT true true /api/publication/3217842 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lonn EM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023829"><a href="/gui2/?type=authors&mode=browse&sel=10023829" target="_blank">Keltai K (<span class="authorship-author-name">Keltai Katalin</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat</span>) </a> </span> <span class="author-affil">Semmelweis Egyetem</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002738"><a href="/gui2/?type=authors&mode=browse&sel=10002738" target="_blank">Keltai M (<span class="authorship-author-name">Keltai Mátyás</span> <span class="authorAux-mtmt"> Klinikai kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (33) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10016411"><a href="/gui2/?type=authors&mode=browse&sel=10016411" target="_blank">L Bajnok (<span class="authorship-author-name">Bajnok László Zoltán</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Általános Orvostudományi Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >E Baranyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >E Bartfai </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >E Bod </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >B Bodis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >I Czuriga </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >E Huber </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012397"><a href="/gui2/?type=authors&mode=browse&sel=10012397" target="_blank">E Mezosi (<span class="authorship-author-name">Mezősi Emese</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >F Poor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >E Somos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Z Tarjanyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >T Tatrai </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >J Tomcsanyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >A Vertes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023788"><a href="/gui2/?type=authors&mode=browse&sel=10023788" target="_blank">A Zsary (<span class="authorship-author-name">Zsáry András</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat, intenzív</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">HOPE-3 Investigators</span> </div> <div><a target="_blank" href="/api/publication/3217842?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3217842" target="_blank">Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">374</span> <span class="journal-issue">21</span> <span class="page"> pp 2009-2020 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1056/NEJMoa1600175" target="_blank" href="https://doi.org/10.1056/NEJMoa1600175"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000376443500004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000376443500004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84969161167" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84969161167"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27041480" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27041480&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 600</span> | Független: 534 | Függő: 66 | Nem jelölt: 0 | WoS jelölt: 540 | Scopus jelölt:&nbsp;573 | WoS/Scopus jelölt:&nbsp;600 | DOI jelölt:&nbsp;558 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3217842&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3217842</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 3217842</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 15:34 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.01.23. 18:25 Vasvari Lilian (MTMT Központ, admin) </div> </div></div>