https://m2.mtmt.hu/ eng 2026-08-24 09:15 JournalArticle 32169755 VALIDATED true 0 false 2026-05-21T02:38:13.223+0000 2025-07-04T06:50:11.393+0000 2021-09-01T06:40:06.978+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2026-05-11T12:57:25.234+0000 2023-02-10T10:13:16.179+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tarszabó, Róbert Influence of Vitamin D on the Vasoactive Effect of Estradiol in a Rat Model of Polycystic Ovary Syndrome true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 22 17 9404 9404 12 2021 We examined the vasoactive effect of estradiol in a rat model of early PCOS and the influence of vitamin D deficiency (VDD). We created a model of chronic hyperandrogenism and VDD in adolescent female Wistar rats (N = 46) with four experimental groups: vitamin D supplemented (T-D+), VDD (T-D-), hyperandrogenic and vitamin D supplemented (T+D+), and hyperandrogenic and VDD (T+D-). T+ groups received an 8-week-long transdermal Androgel treatment, D- animals were on vitamin D-reduced diet and D+ rats were supplemented orally with vitamin D3. Estrogen-induced vasorelaxation of thoracic aorta segments were measured with a wire myograph system with or without the inhibition of endothelial nitric oxide synthase (eNOS) or cyclooxygenase-2 (COX-2). The distribution of estrogen receptor (ER), eNOS and COX-2 in the aortic wall was assessed by immunohistochemistry. VDD aortas showed significantly lower estradiol-induced relaxation independently of androgenic status that was further decreased by COX-2 inhibition. COX-2 inhibition failed to alter vessel function in D+ rats. Inhibition of eNOS abolished the estradiol-induced relaxation in all groups. Changes in vascular function in VDD were accompanied by significantly decreased ER and eNOS staining. Short-term chronic hyperandrogenism failed to, but VDD induced vascular dysfunction, compromised estrogen-dependent vasodilatation and changes in ER and eNOS immunostaining. Funding 2013488 /api/funding/2013488 false true Funding 2013489 /api/funding/2013489 false true Funding 2007488 /api/funding/2007488 false true Funding 2007489 /api/funding/2007489 false true Funding 2013490 /api/funding/2013490 false true Funding 2013491 /api/funding/2013491 false true true true NATIONAL 2021 true true true false true false GOLD 2026-05-21 true https://doi.org/10.3390/ijms22179404 3 0 3 1 2 3 3 3 3 3 3 1 1 1 2 0 3 1 3 1 0 13 13 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 1 2 1 2024 0 0 0 0 0 2025 0 1 0 1 0 D1 false 10009921,10075334,10065600 false false false 2021-08-31T06:40:15.143+0000 I. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Nyírő Gyula Kórház (OMIII); Országos Mentális, Ideggyógyászati és Idegsebés...; Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 13 38 7 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97257299 /api/authorship/97257299 1 0.071 true false true Author 10036698 /api/author/10036698 Tarszabó Róbert true 10036698 true Tarszabó Róbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257300 /api/authorship/97257300 2 0.071 false false false Author 10075180 /api/author/10075180 Bányai Bálint Péter true true Bányai Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257301 /api/authorship/97257301 3 0.071 false false false Author 10025626 /api/author/10025626 Ruisanchez Éva true 10025626 true Ruisanchez Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257302 /api/authorship/97257302 4 0.071 false false false Author 10077542 /api/author/10077542 Péterffy Borbála true true Péterffy Borbála true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257303 /api/authorship/97257303 5 0.071428575 false false false Korsós-Novák Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257304 /api/authorship/97257304 6 0.071 false false false Author 10061648 /api/author/10061648 Lajtai Krisztina true 10061648 true Lajtai Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257305 /api/authorship/97257305 7 0.071 false false false Author 10065600 /api/author/10065600 Sziva Réka Eszter true true Sziva Réka Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257306 /api/authorship/97257306 8 0.071 false false false Author 10075334 /api/author/10075334 Gerszi Dóra true true Gerszi Dóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257307 /api/authorship/97257307 9 0.071 false false false Author 10032730 /api/author/10032730 Hosszú Ádám true 10032730 true Hosszú Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257308 /api/authorship/97257308 10 0.071 false false false Author 10022169 /api/author/10022169 Benkő Rita true 10022169 true Benkő Rita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257309 /api/authorship/97257309 11 0.071 false false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257310 /api/authorship/97257310 12 0.071 false true false Author 10020503 /api/author/10020503 Horvath Eszter Mária true 10020503 true Horváth Eszter Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257311 /api/authorship/97257311 13 0.071 false true false Author 10033861 /api/author/10033861 Masszi Gabriella true 10033861 true Masszi Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97257312 /api/authorship/97257312 14 0.071 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19195813 /api/publicationidentifier/19195813 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms22179404 https://doi.org/10.3390/ijms22179404 false true PublicationIdentifier 19396962 /api/publicationidentifier/19396962 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000694439300001 https://www.webofscience.com/wos/woscc/full-record/000694439300001 false true PublicationIdentifier 19231176 /api/publicationidentifier/19231176 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85113861570 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113861570 false true PublicationIdentifier 19866831 /api/publicationidentifier/19866831 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34502321 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34502321&dopt=Abstract true true Classification 12124 /api/classification/12124 true true SjrRating 11203857 /api/sjrrating/11203857 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1607 /api/classificationexternal/1607 true 1607 true D1 DIRECT true true /api/publication/32169755 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10036698"><a href="/gui2/?type=authors&mode=browse&sel=10036698" target="_blank">Tarszabó Róbert ✉ (<span class="authorship-author-name">Tarszabó Róbert</span> <span class="authorAux-mtmt"> Kórélettan - nőgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075180"><a href="/gui2/?type=authors&mode=browse&sel=10075180" target="_blank">Bányai Bálint (<span class="authorship-author-name">Bányai Bálint Péter</span> <span class="authorAux-mtmt"> Élettan, Transzlációs medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025626"><a href="/gui2/?type=authors&mode=browse&sel=10025626" target="_blank">Ruisanchez Éva (<span class="authorship-author-name">Ruisanchez Éva</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077542"><a href="/gui2/?type=authors&mode=browse&sel=10077542" target="_blank">Péterffy Borbála (<span class="authorship-author-name">Péterffy Borbála</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Korsós-Novák Ágnes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061648"><a href="/gui2/?type=authors&mode=browse&sel=10061648" target="_blank">Lajtai Krisztina (<span class="authorship-author-name">Lajtai Krisztina</span> <span class="authorAux-mtmt"> Szülészet - nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065600"><a href="/gui2/?type=authors&mode=browse&sel=10065600" target="_blank">Sziva Réka Eszter (<span class="authorship-author-name">Sziva Réka Eszter</span> <span class="authorAux-mtmt"> Szülészet-Nőgyógyászat, Nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075334"><a href="/gui2/?type=authors&mode=browse&sel=10075334" target="_blank">Gerszi Dóra (<span class="authorship-author-name">Gerszi Dóra</span> <span class="authorAux-mtmt"> szülészet - nőgyógyászat, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032730"><a href="/gui2/?type=authors&mode=browse&sel=10032730" target="_blank">Hosszú Ádám (<span class="authorship-author-name">Hosszú Ádám</span> <span class="authorAux-mtmt"> nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/I. Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022169"><a href="/gui2/?type=authors&mode=browse&sel=10022169" target="_blank">Benkő Rita (<span class="authorship-author-name">Benkő Rita</span> <span class="authorAux-mtmt"> Humán és orvosi biológia, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth Eszter Mária<sup>**</sup> (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10033861"><a href="/gui2/?type=authors&mode=browse&sel=10033861" target="_blank">Masszi Gabriella<sup>**</sup> (<span class="authorship-author-name">Masszi Gabriella</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil">Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Nyírő Gyula Hospital</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32169755" target="_blank">Influence of Vitamin D on the Vasoactive Effect of Estradiol in a Rat Model of Polycystic Ovary Syndrome</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">17</span> <span class="page"> Paper 9404. 12 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms22179404" target="_blank" href="https://doi.org/10.3390/ijms22179404"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000694439300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000694439300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85113861570" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113861570"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34502321" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34502321&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 1 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32169755&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32169755</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Hypertension Society, Dean of the Medical Faculty, Semmelweis University, (PD-132851) Funder: HSRF, (K-125174) Funder: HSRF, (Fight for the Women’s Hearts Medical Foundation), (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) </div> <div class="lastModified">Last Modified: 2025.07.04. 08:50 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> </div></div>