https://m2.mtmt.hu/ hun 2026-03-17 16:52 JournalArticle 32156982 APPROVED true 0 false 2026-02-02T09:03:06.602+0000 2025-02-25T22:57:37.743+0000 2021-08-25T14:40:42.424+0000 true 10073889 Mózner Orsolya /api/author/10073889 Author true 2026-02-02T09:01:23.878+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mózner, Orsolya Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants true true /api/journal/10041705 REVIEWED true false 10041705 false 10041705 true 2077-0375 Journal FOREIGN 11 8 586 586 10 2021 In the human ATP2B4 gene, coding for the plasma membrane calcium pump PMCA4b, a minor haplotype results in the decreased expression of this membrane protein in erythroid cells. The presence of this haplotype and the consequently reduced PMCA4b expression have been suggested to affect red blood cell hydration and malaria susceptibility. By using dual-luciferase reporter assays, we have localized the erythroid-specific regulatory region within the haplotype of the ATP2B4 gene, containing predicted GATA1 binding sites that are affected by SNPs in the minor haplotype. Our results show that, in human erythroid cells, the regulation of ATP2B4 gene expression is significantly affected by GATA1 expression, and we document the role of specific SNPs involved in predicted GATA1 binding. Our findings provide a mechanistic explanation at the molecular level for the reduced erythroid-specific PMCA4b expression in carriers of ATP2B4 gene polymorphic variants. Funding 2007284 /api/funding/2007284 false true true 2021 true true true false true false GOLD 2026-02-02 true https://doi.org/10.3390/membranes11080586 6 0 6 5 1 6 6 6 4 6 6 5 5 5 1 0 6 5 6 5 0 3 3 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 2 1 2 1 Q2 false 10073889,1241938 false false false 2021-09-05T12:05:20.018+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Doktori Iskola (SE); Enzimológiai Intézet (TTK) 3 32 3 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97181674 /api/authorship/97181674 1 0.333 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97181675 /api/authorship/97181675 2 0.333 true false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97181676 /api/authorship/97181676 3 0.333 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19161177 /api/publicationidentifier/19161177 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/membranes11080586 https://doi.org/10.3390/membranes11080586 false true PublicationIdentifier 19313969 /api/publicationidentifier/19313969 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000689454400001 https://www.webofscience.com/wos/woscc/full-record/000689454400001 true true PublicationIdentifier 19161179 /api/publicationidentifier/19161179 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85112639733 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85112639733 false true PublicationIdentifier 19313975 /api/publicationidentifier/19313975 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34436349 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34436349&dopt=Abstract true true SjrRating 11202038 /api/sjrrating/11202038 104 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 true 1501 true Q2 DIRECT true true Reference 22432296 /api/reference/22432296 1 10.1007/978-3-030-12457-1_5 false true Reference 22432297 /api/reference/22432297 2 10.1101/cshperspect.a035113 false true Reference 22432298 /api/reference/22432298 3 10.1016/j.bbamcr.2015.12.011 false true Reference 22432299 /api/reference/22432299 4 10.3390/ijms21197344 false true Reference 22432300 /api/reference/22432300 5 10.1016/j.neulet.2017.09.033 false true Reference 22432301 /api/reference/22432301 6 10.1038/nature11334 false true Reference 22432302 /api/reference/22432302 7 10.1093/infdis/jit070 false true Reference 22432303 /api/reference/22432303 8 10.1371/journal.pone.0104790 false true Reference 22432304 /api/reference/22432304 9 10.1016/j.ceca.2017.02.001 false true Reference 22432305 /api/reference/22432305 10 10.1172/JCI94378 false true Reference 22432306 /api/reference/22432306 11 10.1093/nar/gkg605 false true Reference 22432307 /api/reference/22432307 12 10.1093/bioinformatics/18.2.333 false true Reference 22432308 /api/reference/22432308 13 10.1038/s41467-019-13480-z false true Reference 22432309 /api/reference/22432309 14 10.1371/journal.pgen.1008027 false true Reference 22432310 /api/reference/22432310 15 10.1101/535898 false true Reference 22432311 /api/reference/22432311 16 10.1038/ng0695-224 false true Reference 22432312 /api/reference/22432312 17 10.1101/2021.06.30.450498 false true Reference 22432313 /api/reference/22432313 18 10.1186/s12936-021-03832-w false true /api/publication/32156982 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka<sup>*</sup> (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32156982" target="_blank">Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants</a></div> <div> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0375">2077-0375</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">8</span> <span class="page"> Paper 586. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes11080586" target="_blank" href="https://doi.org/10.3390/membranes11080586"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000689454400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000689454400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85112639733" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85112639733"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34436349" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34436349&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Process Chemistry and Technology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Filtration and Separation&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 5 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32156982&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32156982</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (1017403) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2025.02.25. 23:57 Ladányi Gusztáv (MTMT API user, admin) </div> </div></div>