https://m2.mtmt.hu/ eng 2026-10-23 01:17 JournalArticle 32156655 VALIDATED true Funding Agency and Grant Number: Oklahoma Center for the Advancement of Science and Technology; National Institute on Aging [R01-AG047879, R01-AG055395, R01-AG068295, K01AG073614]; National Institute of Neurological Disorders and Stroke (NINDS) [R01-NS100782]; National Cancer Institute (NCI) [R01-CA255840-01]; National Institute of General Medical Sciences Oklahoma Shared Clinical and Translational Resources (OSCTR) [GM104938]; Presbyterian Health Foundation; Geroscience Training Program in Oklahoma [(T32AG052363]; Oklahoma Nathan Shock Center [P30AG050911]; Cellular and Molecular GeroScience CoBRE [1P20GM125528, sub#5337]; American Federation for Aging Research (Irene/Diamond Postdoctoral Transition Award); NKFIH (Nemzeti Szivlabor) Funding text: This work was supported by grants from the Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (R01-AG047879; R01-AG055395; R01-AG068295: K01AG073614 to ST), the National Institute of Neurological Disorders and Stroke (NINDS; R01-NS100782), the National Cancer Institute (NCI; R01-CA255840-01), the National Institute of General Medical Sciences Oklahoma Shared Clinical and Translational Resources (OSCTR) (GM104938, to AY), the Presbyterian Health Foundation, the NIA-supported Geroscience Training Program in Oklahoma (T32AG052363), the Oklahoma Nathan Shock Center (P30AG050911), the Cellular and Molecular GeroScience CoBRE (1P20GM125528, sub#5337), the American Federation for Aging Research (Irene/Diamond Postdoctoral Transition Award to PB), and the NKFIH (Nemzeti Szivlabor). 0 false 2026-10-22T07:52:27.537+0000 2024-07-16T08:24:37.928+0000 2021-08-25T12:10:27.037+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-07-31T08:27:36.363+0000 2026-07-31T08:27:36.363+0000 2023-09-02T13:40:02.866+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2023-12-11T17:21:36.117+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tarantini, Stefano Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 43 5 2427 2440 2427 14 2021 Moment-to-moment adjustment of regional cerebral blood flow to neuronal activity via neurovascular coupling (NVC or "functional hyperemia") has a critical role in maintenance of healthy cognitive function. Aging-induced impairment of NVC responses importantly contributes to age-related cognitive decline. Advanced aging is associated with increased prevalence of senescent cells in the cerebral microcirculation, but their role in impaired NVC responses remains unexplored. The present study was designed to test the hypothesis that a validated senolytic treatment can improve NVC responses and cognitive performance in aged mice. To achieve this goal, aged (24-month-old) C57BL/6 mice were treated with ABT263/Navitoclax, a potent senolytic agent known to eliminate senescent cells in the aged mouse brain. Mice were behaviorally evaluated (radial arms water maze) and NVC was assessed by measuring CBF responses (laser speckle contrast imaging) in the somatosensory whisker barrel cortex evoked by contralateral whisker stimulation. We found that NVC responses were significantly impaired in aged mice. ABT263/Navitoclax treatment improved NVC response, which was associated with significantly improved hippocampal-encoded functions of learning and memory. ABT263/Navitoclax treatment did not significantly affect endothelium-dependent acetylcholine-induced relaxation of aorta rings. Thus, increased presence of senescent cells in the aged brain likely contributes to age-related neurovascular uncoupling, exacerbating cognitive decline. The neurovascular protective effects of ABT263/Navitoclax treatment highlight the preventive and therapeutic potential of senolytic treatments (as monotherapy or as part of combination treatment regimens) as effective interventions in patients at risk for vascular cognitive impairment (VCI). 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano ✉ (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian Priya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Delfavero Jordan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csipo Tamas (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss Tamas (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/I. Department of Pediatrics; <span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Paediatrics and Paediatric Health Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyúl-Tóth Ádám (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021094"><a href="/gui2/?type=authors&mode=browse&sel=10021094" target="_blank">Toth Peter (<span class="authorship-author-name">Tóth Péter József</span> <span class="authorAux-mtmt"> Idegsebészet, cerebrovaszkuláris kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/<span title="Research Groups">RG</span>/MTA-PTE Clinical Neuroscience MR Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ahire Chetan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyo Zoltan (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32156655" target="_blank">Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">43</span> <span class="journal-issue">5</span> <span class="page"> pp 2427-2440 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1007/s11357-021-00440-z" target="_blank" href="https://doi.org/10.1007/s11357-021-00440-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000687953400002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000687953400002"> WoS </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:black" title="137500" target="_blank" href="https://real.mtak.hu/137500"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85113317374" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113317374"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34427858" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34427858&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 99</span> | Independent citation: 54 | Self citation: 45 | Unknown citation: 0 | Number of citations in WoS: 97 | Number of citations in Scopus:&nbsp;96 | WoS/Scopus assigned:&nbsp;99 | Number of citations with DOI:&nbsp;98 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32156655&sort=publishedYear,desc&sort=title"> Number of cited publications: 34 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32156655</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (NKFIH (Nemzeti Szívlabor)) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/32156655/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2024.07.16. 10:24 Rozália Zeller (SZTE admin5) </div> <div class="lockedBy">Centrally managed 2023.12.11. 18:21 Éva Pécsi (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Oklahoma Center for the Advancement of Science and Technology; National Institute on Aging [R01-AG047879, R01-AG055395, R01-AG068295, K01AG073614]; National Institute of Neurological Disorders and Stroke (NINDS) [R01-NS100782]; National Cancer Institute (NCI) [R01-CA255840-01]; National Institute of General Medical Sciences Oklahoma Shared Clinical and Translati...</pre> </div></div>