https://m2.mtmt.hu/ hun 2026-09-22 20:42 JournalArticle 32155156 VALIDATED true Funding Agency and Grant Number: Hungarian Human Resources Development Operational Program [EFOP-3.6.2-16-2017-00006]; Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary of the Therapy thematic program of the Semmelweis University [2020-4.1.1.-TKP2020]; National Research, Development and Innovation Office [EFOP-3.6.1-16-2016-00022, GINOP 2.3.2-15-2016-00048]; Central Library of Semmelweis University Funding text: This study was supported by the Hungarian Human Resources Development Operational Program (EFOP-3.6.2-16-2017-00006). Additional support was received from the Thematic Excellence Program (2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary, within the framework of the Therapy thematic program of the Semmelweis University. Support was also received from an Economic Development and Innovation Operative Program Grant (GINOP 2.3.2-15-2016-00048) and an Institutional Developments for Enhancing Intelligent Specialization Grant (EFOP-3.6.1-16-2016-00022) of the National Research, Development and Innovation Office. All funds issued by the Hungarian government with cooperation of the European Union. Funders did not have any role in the research. For open access publication support was received through the Central Library of Semmelweis University. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. 0 false 2026-09-05T14:03:19.189+0000 2026-06-18T16:49:05.316+0000 2021-08-24T12:35:17.381+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-06-18T16:49:05.207+0000 2025-04-18T13:44:58.750+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Czumbel, László Márk Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation : A Meta-Analysis true true /api/journal/10050307 REVIEWED true false 10050307 false 10050307 true 2296-875X 2296-875X Journal FOREIGN 8 681028 681028 16 2021 Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established. Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application. Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used. Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85-0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66-0.82) and 46% (ES = 0.46, 95% CI:0.28-0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger. Funding 2002489 /api/funding/2002489 false true Funding 2002490 /api/funding/2002490 false true Funding 2002491 /api/funding/2002491 false true Funding 2002492 /api/funding/2002492 false true true 2021 true true true false true false GOLD 2026-09-05 true https://doi.org/10.3389/fsurg.2021.681028 48 0 48 47 1 47 47 42 34 47 47 47 47 47 1 0 48 47 48 47 0 11 11 Folyóiratcikk Journal Article 24 48 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 8 7 8 7 2023 0 9 9 9 9 2024 0 17 17 17 17 2025 0 12 12 12 12 2026 0 2 2 2 2 Q2 false false false false 2021-08-23T12:46:17.586+0000 Farmakognóziai Intézet (SZTE / GYTK); Klinikai Orvostudományi Doktori Iskola (SZTE / DI); Népegészségtani Intézet (SZTE / SZAOK); Orálbiológiai Tanszék (SE / FOK); Szemészeti Klinika (PTE / ÁOK); Transzlációs Medicina Intézet (PTE / ÁOK); Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI) 10 55 7 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97170590 /api/authorship/97170590 1 0.1 true false false Author 10060811 /api/author/10060811 Czumbel László Márk true 10060811 true Czumbel László Márk true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170591 /api/authorship/97170591 2 0.1 false false false Author 10026139 /api/author/10026139 Farkasdi Sándor true 10026139 true Farkasdi Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170592 /api/authorship/97170592 3 0.1 false false false Author 10048360 /api/author/10048360 Gede Noémi true 10048360 true Gede Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170593 /api/authorship/97170593 4 0.1 false false false Author 10040441 /api/author/10040441 Mikó Alexandra true 10040441 true Mikó Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170594 /api/authorship/97170594 5 0.1 false false false Author 10001143 /api/author/10001143 Csupor Dezső true 10001143 true Csupor Dezső true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170595 /api/authorship/97170595 6 0.1 false false false Author 10028688 /api/author/10028688 Lukács Anita true 10028688 true Lukács Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170596 /api/authorship/97170596 7 0.1 false false false Author 10076447 /api/author/10076447 Gaál Valéria true true Gaál Valéria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170597 /api/authorship/97170597 8 0.1 false false false Author 10070369 /api/author/10070369 Kiss Szabolcs true true Kiss Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170598 /api/authorship/97170598 9 0.1 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97170599 /api/authorship/97170599 10 0.1 false true true Author 10006652 /api/author/10006652 Varga Gábor true 10006652 true Varga Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19156357 /api/publicationidentifier/19156357 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fsurg.2021.681028 https://doi.org/10.3389/fsurg.2021.681028 false true PublicationIdentifier 19202821 /api/publicationidentifier/19202821 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000687241000001 https://www.webofscience.com/wos/woscc/full-record/000687241000001 false true PublicationIdentifier 19202463 /api/publicationidentifier/19202463 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85113288601 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113288601 true true PublicationIdentifier 19156356 /api/publicationidentifier/19156356 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34422892 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34422892&dopt=Abstract false true PublicationIdentifier 20422186 /api/publicationidentifier/20422186 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 23316 http://publicatio.bibl.u-szeged.hu/23316 false true Classification 12358 /api/classification/12358 true true Keyword 3375201 /api/keyword/3375201 true true SjrRating 11235531 /api/sjrrating/11235531 190 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true Q2 DIRECT true true /api/publication/32155156 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060811"><a href="/gui2/?type=authors&mode=browse&sel=10060811" target="_blank">Czumbel László Márk (<span class="authorship-author-name">Czumbel László Márk</span> <span class="authorAux-mtmt"> Fogorvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026139"><a href="/gui2/?type=authors&mode=browse&sel=10026139" target="_blank">Farkasdi Sándor (<span class="authorship-author-name">Farkasdi Sándor</span> <span class="authorAux-mtmt"> orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048360"><a href="/gui2/?type=authors&mode=browse&sel=10048360" target="_blank">Gede Noémi (<span class="authorship-author-name">Gede Noémi</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040441"><a href="/gui2/?type=authors&mode=browse&sel=10040441" target="_blank">Mikó Alexandra (<span class="authorship-author-name">Mikó Alexandra</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001143"><a href="/gui2/?type=authors&mode=browse&sel=10001143" target="_blank">Csupor Dezső (<span class="authorship-author-name">Csupor Dezső</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Fitokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028688"><a href="/gui2/?type=authors&mode=browse&sel=10028688" target="_blank">Lukács Anita (<span class="authorship-author-name">Lukács Anita</span> <span class="authorAux-mtmt"> toxikológia, megelőzés</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Népegészségtani Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Biológia Intézet">BI</span>/Élettani, Szervezettani és Idegtudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076447"><a href="/gui2/?type=authors&mode=browse&sel=10076447" target="_blank">Gaál Valéria (<span class="authorship-author-name">Gaál Valéria</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szemészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070369"><a href="/gui2/?type=authors&mode=browse&sel=10070369" target="_blank">Kiss Szabolcs (<span class="authorship-author-name">Kiss Szabolcs</span> <span class="authorAux-mtmt"> Gasztroenterológia, hematológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Klinikai Orvostudományi Doktori Iskola; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10006652"><a href="/gui2/?type=authors&mode=browse&sel=10006652" target="_blank">Varga Gábor ✉ (<span class="authorship-author-name">Varga Gábor</span> <span class="authorAux-mtmt"> Élettan, orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32155156" target="_blank">Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation : A Meta-Analysis</a></div> <div> <span class="journal-title">FRONTIERS IN SURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-875X">2296-875X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-875X">2296-875X</a>)</span>: <span class="journal-volume">8</span> <span class="page"> Paper 681028. 16 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fsurg.2021.681028" target="_blank" href="https://doi.org/10.3389/fsurg.2021.681028"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000687241000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000687241000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85113288601" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113288601"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34422892" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34422892&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="23316" target="_blank" href="http://publicatio.bibl.u-szeged.hu/23316"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Surgery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 48</span> | Független: 47 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 42 | Scopus jelölt:&nbsp;34 | WoS/Scopus jelölt:&nbsp;47 | DOI jelölt:&nbsp;47 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32155156&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32155156</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, (EFOP-3.6.1-16-2016-00022) Támogató: EFOP, GINOP - STAY ALIVE(GINOP-2.3.2-15-2016-00048) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2026.06.18. 18:49 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian Human Resources Development Operational Program [EFOP-3.6.2-16-2017-00006]; Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary of the Therapy thematic program of the Semmelweis University [2020-4.1.1.-TKP2020]; National Research, Development and Innovation Office [EFOP-3.6.1-16-2016-00022, GINOP 2.3.2-15-2016-00048]; C...</pre> </div></div>