https://m2.mtmt.hu/ eng 2026-07-26 16:51 JournalArticle 32151851 APPROVED true 0 false 2026-02-16T15:12:50.901+0000 2026-02-16T15:12:25.318+0000 2021-08-22T17:40:50.068+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-02-16T15:11:38.456+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Oláh, Viktor János Small Size of Recorded Neuronal Structures Confines the Accuracy in Direct Axonal Voltage Measurements true true /api/journal/10047435 REVIEWED true false 10047435 false 10047435 true 2373-2822 Journal FOREIGN 8 4 ENEURO.0059-21.2021 ENEURO.0059-21.2021 20 2021 Patch-clamp instruments including amplifier circuits and pipettes affect the recorded voltage signals. We hypothesized that realistic and complete in silico representation of recording instruments together with detailed morphology and biophysics of small recorded structures will reveal signal distortions and provide a tool that predicts native, instrument-free electrical signals from distorted voltage recordings. Therefore, we built a model that was verified by small axonal recordings. The model accurately recreated actual action potential (AP) measurements with typical recording artefacts and predicted the native electrical behavior. The simulations verified that recording instruments substantially filter voltage recordings. Moreover, we revealed that instrumentation directly interferes with local signal generation depending on the size of the recorded structures, which complicates the interpretation of recordings from smaller structures, such as axons. However, our model offers a straightforward approach that predicts the native waveforms of fast voltage signals and the underlying conductances even from the smallest neuronal structures. Funding 2013680 /api/funding/2013680 false true Funding 2015188 /api/funding/2015188 false true true true 2021 true true true false true false GOLD 2026-02-16 true https://doi.org/10.1523/ENEURO.0059-21.2021 9 0 9 6 3 9 9 9 9 9 9 6 6 6 3 0 9 6 9 6 0 3 3 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 1 2 1 2023 0 4 3 4 3 2024 0 3 2 3 2 Q1 false 10014148 false false false 2021-08-21T17:43:07.625+0000 Celluláris Neurofarmakológia Kutatócsoport (HRN KOKI); Doktori Iskola (SE) 3 11 2 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97136412 /api/authorship/97136412 1 0.333 true false false Author 10062706 /api/author/10062706 Oláh Viktor János true 10062706 true Oláh Viktor János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97136413 /api/authorship/97136413 2 0.33333334 false false false Author 10103504 /api/author/10103504 Tarcsay Gergely true true Tarcsay Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97136414 /api/authorship/97136414 3 0.333 false true true Author 10014148 /api/author/10014148 Brunner János true 10014148 true Brunner János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19146795 /api/publicationidentifier/19146795 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1523/ENEURO.0059-21.2021 https://doi.org/10.1523/ENEURO.0059-21.2021 false true PublicationIdentifier 19146797 /api/publicationidentifier/19146797 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85111676599 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85111676599 false true PublicationIdentifier 19146798 /api/publicationidentifier/19146798 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34257077 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257077&dopt=Abstract false true PublicationIdentifier 31443658 /api/publicationidentifier/31443658 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0059-21.2021 https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0059-21.2021 false true SjrRating 11225085 /api/sjrrating/11225085 250 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/32151851 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062706"><a href="/gui2/?type=authors&mode=browse&sel=10062706" target="_blank">Oláh Viktor János (<span class="authorship-author-name">Oláh Viktor János</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neuropharmacology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103504"><a href="/gui2/?type=authors&mode=browse&sel=10103504" target="_blank">Tarcsay Gergely (<span class="authorship-author-name">Tarcsay Gergely</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014148"><a href="/gui2/?type=authors&mode=browse&sel=10014148" target="_blank">Brunner János ✉ (<span class="authorship-author-name">Brunner János</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neuropharmacology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32151851" target="_blank">Small Size of Recorded Neuronal Structures Confines the Accuracy in Direct Axonal Voltage Measurements</a></div> <div> <span class="journal-title">ENEURO</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2373-2822">2373-2822</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">4</span> <span class="page"> Paper ENEURO.0059-21.2021. 20 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1523/ENEURO.0059-21.2021" target="_blank" href="https://doi.org/10.1523/ENEURO.0059-21.2021"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85111676599" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85111676599"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34257077" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257077&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0059-21.2021" target="_blank" href="https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0059-21.2021"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 6 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32151851&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32151851</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (Janos Bolyai Research Fellowship) Funder: MTA Bolyai pályázat, ERC-CoG(772452) </div> <div class="lastModified">Last Modified: 2026.02.16. 16:12 Gergely Tarcsay (neurobiológia) </div> </div></div>