https://m2.mtmt.hu/ hun 2026-09-20 15:29 JournalArticle 32132555 VALIDATED true 0 false 2026-05-21T01:28:07.166+0000 2025-04-18T14:13:29.836+0000 2021-08-16T07:10:10.754+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2024-05-21T09:49:01.357+0000 2025-04-18T14:13:30.033+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Reulen, Raoul C. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study true true /api/journal/1736 REVIEWED true false 1736 false 1736 true 0017-5749 1468-3288 Journal FOREIGN 70 8 1520 1528 1520 9 2021 Background Survivors of childhood cancer are at risk of subsequent primary neoplasms (SPNs), but the risk of developing specific digestive SPNs beyond age 40 years remains uncertain. We investigated risks of specific digestive SPNs within the largest available cohort worldwide. Methods The PanCareSurFup cohort includes 69 460 five-year survivors of childhood cancer from 12 countries in Europe. Risks of digestive SPNs were quantified using standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence. Results 427 digestive SPNs (214 colorectal, 62 liver, 48 stomach, 44 pancreas, 59 other) were diagnosed in 413 survivors. Wilms tumour (WT) and Hodgkin lymphoma (HL) survivors were at greatest risk (SIR 12.1; 95% CI 9.6 to 15.1; SIR 7.3; 95% CI 5.9 to 9.0, respectively). The cumulative incidence increased the most steeply with increasing age for WT survivors, reaching 7.4% by age 55% and 9.6% by age 60 years (1.0% expected based on general population rates). Regarding colorectal SPNs, WT and HL survivors were at greatest risk; both seven times that expected. By age 55 years, 2.3% of both WT (95% CI 1.4 to 3.9) and HL (95% CI 1.6 to 3.2) survivors had developed a colorectal SPN-comparable to the risk among members of the general population with at least two first-degree relatives affected. Conclusions Colonoscopy surveillance before age 55 is recommended in many European countries for individuals with a family history of colorectal cancer, but not for WT and HL survivors despite a comparable risk profile. Clinically, serious consideration should be given to the implementation of colonoscopy surveillance while further evaluation of its benefits, harms and cost-effectiveness in WT and HL survivors is undertaken. true true 2021 true true true false true false GOLD 2026-05-21 true https://doi.org/10.1136/gutjnl-2020-322237 11 0 11 2 2 11 11 10 9 11 11 2 2 2 9 0 11 2 11 2 0 6 6 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 0 1 0 2022 0 3 1 3 1 2023 0 2 1 2 1 2024 0 3 0 3 0 2025 0 1 0 1 0 2026 0 1 0 1 0 D1 false false false false 2021-08-15T07:15:59.372+0000 II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K) 2 18 1 49 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97039551 /api/authorship/97039551 1 0.0 true false false Reulen Raoul C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039552 /api/authorship/97039552 2 0.0 false false false Wong Kwok F. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039553 /api/authorship/97039553 3 0.0 false false false Bright Chloe J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039554 /api/authorship/97039554 4 0.0 false false false Winter David L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039555 /api/authorship/97039555 5 0.0 false false false Alessi Daniela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039556 /api/authorship/97039556 6 0.0 false false false Allodji Rodrigue M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039557 /api/authorship/97039557 7 0.0 false false false Bagnasco Francesca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039558 /api/authorship/97039558 8 0.0 false false false Author 10000062 /api/author/10000062 Bárdi Edit true 10000062 true Bardi Edit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039559 /api/authorship/97039559 9 0.0 false false false Bautz Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039560 /api/authorship/97039560 10 0.0 false false false Byrne Julianne true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97039561 /api/authorship/97039561 11 0.0 false false false Feijen Elizabeth A. 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true D1 DIRECT true true /api/publication/32132555 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Reulen Raoul C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000062"><a href="/gui2/?type=authors&mode=browse&sel=10000062" target="_blank">Bardi Edit (<span class="authorship-author-name">Bárdi Edit</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025328"><a href="/gui2/?type=authors&mode=browse&sel=10025328" target="_blank">Jakab Zsuzsanna (<span class="authorship-author-name">Jakab Zsuzsanna</span> <span class="authorAux-mtmt"> Gyermekgyógyászat onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; et al. (49) </div> <div><a target="_blank" href="/api/publication/32132555?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32132555" target="_blank">Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study</a></div> <div> <span class="journal-title">GUT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0017-5749">0017-5749</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1468-3288">1468-3288</a>)</span>: <span class="journal-volume">70</span> <span class="journal-issue">8</span> <span class="page"> pp 1520-1528 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1136/gutjnl-2020-322237" target="_blank" href="https://doi.org/10.1136/gutjnl-2020-322237"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000675439400018" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000675439400018"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85095995713" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85095995713"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33139271" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33139271&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 2 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32132555&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32132555</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.18. 16:13 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>