https://m2.mtmt.hu/ hun 2026-09-21 13:26 JournalArticle 32127259 VALIDATED true Export Date: 10 July 2026; Cited By: 33; Correspondence Address: A. Koller; Department of Translational Medicine, Semmelweis University, Budapest, Hungary; email: akos.koller@gmail.com; CODEN: CVREA 0 false 2026-07-19T09:45:26.702+0000 2026-07-10T10:28:04.965+0000 2021-08-09T08:31:59.006+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-07-11T05:50:03.320+0000 2023-06-20T13:01:15.435+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Koller, Akos Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms ESC Working Group on Coronary Pathophysiology and Microcirculation position paper true true /api/journal/926 REVIEWED true false 926 false 926 true 0008-6363 1755-3245 Journal FOREIGN 118 2 357 371 357 15 2022 Regular aerobic exercise (RAEX) elicits several positive adaptations in all organs and tissues of the body, culminating in improved health and well-being. Indeed, in over half a century, many studies have shown the benefit of RAEX on cardiovascular outcome in terms of morbidity and mortality. RAEX elicits a wide range of functional and structural adaptations in the heart and its coronary circulation, all of which are to maintain optimal myocardial oxygen and nutritional supply during increased demand. Although there is no evidence suggesting that oxidative metabolism is limited by coronary blood flow (CBF) rate in the normal heart even during maximal exercise, increased CBF and capillary exchange capacities have been reported. Adaptations of coronary macro- and microvessels include outward remodeling of epicardial coronary arteries, increased coronary arteriolar size and density, and increased capillary surface area. In addition, there are adjustments in the neural and endothelial regulation of coronary macrovascular tone. Similarly, there are several adaptations at the level of microcirculation, including enhanced smooth muscle dependent pressure-induced myogenic constriction and upregulated endothelium-dependent flow-/shear-stress-induced dilation, increasing the range of diameter change. Alterations in the signaling interaction between coronary vessels and cardiac metabolism have also been described. At the molecular and cellular level, ion channels are key players in the local coronary vascular adaptations to RAEX, with enhanced activation of influx of Ca2+ contributing to the increased myogenic tone (via voltage gated Ca2+ channels) as well as the enhanced endothelium-dependent dilation (via TRPV4 channels). Finally, RAEX elicits a number of beneficial effects on several hemorheological variables that may further improve CBF and myocardial oxygen delivery and nutrient exchange in the microcirculation by stabilizing and extending the range and further optimizing the regulation of myocardial blood flow during exercise. These adaptations also act to prevent and/or delay the development of coronary and cardiac diseases. 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(SE / AOK / K / BOK); I. sz. Belgyógyászati Klinika (PTE / ÁOK); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Sport- és Egészségtudományi Intézet (MTSE); Transzlációs Medicina Intézet (SE / AOK / I) 4 41 5 16 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96988335 /api/authorship/96988335 1 0.063 true false true Author 10002221 /api/author/10002221 Koller Ákos true 10002221 true Koller Akos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96988336 /api/authorship/96988336 2 0.0625 false false false Laughlin M Harold true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96988337 /api/authorship/96988337 3 0.0625 false false false Cenko Edina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96988338 /api/authorship/96988338 4 0.0625 false false false de Wit Cor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true 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/api/keyword/2282 true 2282 true Keyword 5854 /api/keyword/5854 true 5854 true Keyword 1016564 /api/keyword/1016564 true 1016564 true Keyword 1180572 /api/keyword/1180572 true 1180572 true Keyword 1661775 /api/keyword/1661775 true true SjrRating 11311728 /api/sjrrating/11311728 21 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/32127259 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller Akos ✉ (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/Sport- és Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Laughlin M Harold </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cenko Edina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >de Wit Cor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004892"><a href="/gui2/?type=authors&mode=browse&sel=10004892" target="_blank">Tóth Kálmán (<span class="authorship-author-name">Tóth Kálmán</span> <span class="authorAux-mtmt"> Cardiologia-haemorheologia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bugiardini Raffaele </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Trifunovits Danijela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vavlukis Marija </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Manfrini Olivia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013931"><a href="/gui2/?type=authors&mode=browse&sel=10013931" target="_blank">Lelbach Adam (<span class="authorship-author-name">Lelbach Ádám Antal</span> <span class="authorAux-mtmt"> Belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Belgyógyászati és Onkológiai Klinika - Geriátriai Tanszéki Csoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010428"><a href="/gui2/?type=authors&mode=browse&sel=10010428" target="_blank">Dornyei Gabriella (<span class="authorship-author-name">Bednárikné Dörnyei Gabriella</span> <span class="authorAux-mtmt"> Érfiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Padro Teresa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Badimon Lina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tousoulis Dimitris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gielen Stephan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Duncker Dirk J </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32127259" target="_blank">Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms : ESC Working Group on Coronary Pathophysiology and Microcirculation position paper.</a></div> <div> <span class="journal-title">CARDIOVASCULAR RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0008-6363">0008-6363</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1755-3245">1755-3245</a>)</span>: <span class="journal-volume">118</span> <span class="journal-issue">2</span> <span class="page"> pp 357-371 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/cvr/cvab246" target="_blank" href="https://doi.org/10.1093/cvr/cvab246"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000761462900009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000761462900009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85123969207" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85123969207"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34358290" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34358290&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 42</span> | Független: 36 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 36 | Scopus jelölt:&nbsp;33 | WoS/Scopus jelölt:&nbsp;40 | DOI jelölt:&nbsp;41 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32127259&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32127259</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (NKFIH-1281-2/2020), (TKP2020-NKA-17), (K108444), (K116954) Támogató: OTKA, (K132596) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2026.07.10. 12:28 Heronyányi Zsolt (PTE ÁOK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 10 July 2026; Cited By: 33; Correspondence Address: A. Koller; Department of Translational Medicine, Semmelweis University, Budapest, Hungary; email: akos.koller@gmail.com; CODEN: CVREA</pre> </div></div>