Antimicrobial resistance patterns of bacterial pathogens their distribution in university teaching hospitals in Zambia

Kasanga, Maisa; Mukosha, Raphael; Kasanga, Maika; Siyanga, Makomani; Mudenda, Steward; Solochi, Benjamin Bisesa; Chileshe, Misheck; Mwiikisa, Mark J.; Gondwel, Theodore; Kantenga, Timothy; Shibemba, Aaron Lunda; Nakazwe, Ruth; Chitalu, Mwansa; Wu, Jian ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: FUTURE MICROBIOLOGY 1746-0913 16 (11) pp. 811-824 2020
  • SJR Scopus - Microbiology (medical): Q2
Aim: To determine the antimicrobial resistance patterns of bacterial pathogens from urine, blood and wound infections and their distribution by age, sex and location. Materials & methods: A total of 49,168 samples were collected, processed and analyzed. Results: Multidrug resistance was observed in almost all bacterial pathogens in blood urine and wound swabs. In urine and females odds ratio (OR) = 0.864, p = 0.023, OR = 0.909, p = 0.013 urine and neonates were susceptible to antibiotics OR = 0.859, p = 0.003, OR = 0.741, p Escherichia coli in blood, urine and wound swabs. Conclusion: There was a spike in resistance to imipenem, ciprofloxacin and ampicillin against E. coli, Klebsiella pneumoniae, Proteus mirabilis and Proteus species from all three specimen sources. Lay abstract Bacterial infections and microbial resistance are becoming the most challenging problems associated with increased morbidity and mortality. The emergence of antibiotic resistance is a growing concern for people of all ages and settings. This study aimed to determine the antimicrobial resistance patterns of microorganism from urine, blood and wound swabs and their distribution by age, sex and location. The study showed that bacterial isolates from urine and blood were more resistant than isolates from wound infections. Furthermore, bacterial isolates from neonates were resistant to antimicrobial agents used. Bacterial isolates from inpatients were more statistically significant to antimicrobial agents than those from outpatients. There was resistance of bacteria Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Proteus species from all three specimen sources to imipenem, ciprofloxacin, and ampicillin, and the effect of age, sex and location on antibiotic resistance was also significant.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2021-09-20 17:14