https://m2.mtmt.hu/ hun 2026-09-21 05:43 JournalArticle 3211755 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 3211755 2026-07-17T01:03:45.540+0000 2020-12-22T20:31:36.236+0000 2017-04-12T13:20:20.000+0000 true 10015508 Tretter László /api/author/10015508 Author Tretter László (Biokémia) true 10015508 2019-04-15T12:54:36.817+0000 2019-04-15T12:54:36.817+0000 2017-05-16T06:58:10.000+0000 true 10054198 xBökönyi Zita /api/admin/10054198 Admin xBökönyi Zita (INAKTÍV_SE_AOK_OBI_Admin5_BZ, admin) true 10054198 2018-12-19T14:12:22.524+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Tichy Rita (SE_KK_Admin5_TR, admin) true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Bordt, EA true true /api/journal/10000746 REVIEWED DEVELOPMENTAL CELL 1534-5807 1878-1551 true false 10000746 false 10000746 true 1534-5807 1878-1551 Journal FOREIGN 40 6 583 594.e6 583 2017 Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here, we show that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e.g., 50 μM) used to target mitochondrial fission. Respiratory inhibition is rescued by bypassing complex I using yeast NADH dehydrogenase Ndi1. Unexpectedly, respiratory impairment by mdivi-1 occurs without mitochondrial elongation, is not mimicked by Drp1 deletion, and is observed in Drp1-deficient fibroblasts. In addition, mdivi-1 poorly inhibits recombinant Drp1 GTPase activity (Ki > 1.2 mM). Overall, these results suggest that mdivi-1 is not a specific Drp1 inhibitor. The ability of mdivi-1 to reversibly inhibit complex I and modify mitochondrial ROS production may contribute to effects observed in disease models. © 2017 Elsevier Inc. 2017 85016487669 (Tretter László (Biokémia); 2017.04.12. 15:16:06) true true true false true false GREEN 2026-07-17 true https://repo.lib.semmelweis.hu/handle/123456789/6537 480 0 480 468 2 478 480 475 364 480 480 468 468 468 12 0 480 468 480 468 0 1 1 Folyóiratcikk Journal Article 24 478 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 17 17 17 17 2018 0 52 51 52 51 2019 0 41 41 41 41 2020 0 61 58 61 58 2021 0 55 53 55 53 2022 0 67 63 67 63 2023 0 59 58 59 58 2024 0 60 60 60 60 2025 0 46 45 46 45 2026 0 22 22 22 22 D1 false 10015508 false false false 2017-05-16T06:58:10.000+0000 2017-04-12T14:27:48.000+0000 MTA-SE Neurobiokémiai Kutatócsoport (SE / AOK / I / OBI) 2 9 1 21 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 8984189 /api/authorship/8984189 Bordt, EA 1 0.04761905 true false Bordt EA true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819864 true PersonAuthorship 8984190 /api/authorship/8984190 Clerc, P 2 0.04761905 false false Clerc P true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819863 true PersonAuthorship 8984191 /api/authorship/8984191 Roelofs, BA 3 0.04761905 false false Roelofs BA true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819862 true PersonAuthorship 8984192 /api/authorship/8984192 Saladino, AJ 4 0.04761905 false false Saladino AJ true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819861 true PersonAuthorship 8984193 /api/authorship/8984193 Tretter, L [Tretter, László (Biokémia), szerző] MTA-SE Neurobiokémiai Kutatócsoport (SE / AOK / I / OBI) 5 0.04761905 false false Author 10015508 /api/author/10015508 Tretter László (Biokémia) Tretter László true 10015508 true Tretter L true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819860 true PersonAuthorship 8984194 /api/authorship/8984194 Adam-Vizi, V [Ádám, Veronika (idegtudomány, bio...), szerző] MTA-SE Neurobiokémiai Kutatócsoport (SE / AOK / I / OBI) 6 0.04761905 false false Author 10000397 /api/author/10000397 Ádám Veronika (idegtudomány, biokémia) Ádám Veronika true 10000397 true Adam-Vizi V true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819859 true PersonAuthorship 8984195 /api/authorship/8984195 Cherok, E 7 0.04761905 false false Cherok E true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819858 true PersonAuthorship 8984196 /api/authorship/8984196 Khalil, A 8 0.04761905 false false Khalil A true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819857 true PersonAuthorship 8984197 /api/authorship/8984197 Yadava, N 9 0.04761905 false false Yadava N true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819856 true PersonAuthorship 8984198 /api/authorship/8984198 Ge, SX 10 0.04761905 false false Ge SX true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819855 true PersonAuthorship 8984199 /api/authorship/8984199 Francis, TC 11 0.04761905 false false Francis TC true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819854 true PersonAuthorship 8984200 /api/authorship/8984200 Kennedy, NW 12 0.04761905 false false Kennedy NW true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819853 true PersonAuthorship 8984201 /api/authorship/8984201 Picton, LK 13 0.04761905 false false Picton LK true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819852 true PersonAuthorship 8984202 /api/authorship/8984202 Kumar, T 14 0.04761905 false false Kumar T true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819851 true PersonAuthorship 8984203 /api/authorship/8984203 Uppuluri, S 15 0.04761905 false false Uppuluri S true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819850 true PersonAuthorship 8984204 /api/authorship/8984204 Miller, AM 16 0.04761905 false false Miller AM true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819849 true PersonAuthorship 8984205 /api/authorship/8984205 Itoh, K 17 0.04761905 false false Itoh K true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819848 true PersonAuthorship 8984206 /api/authorship/8984206 Karbowski, M 18 0.04761905 false false Karbowski M true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819847 true PersonAuthorship 8984207 /api/authorship/8984207 Sesaki, H 19 0.04761905 false false Sesaki H true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819846 true PersonAuthorship 8984208 /api/authorship/8984208 Hill, RB 20 0.04761905 false false Hill RB true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819845 true PersonAuthorship 8984209 /api/authorship/8984209 Polster, BM 21 0.04761905 false true Polster BM true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 25819844 true 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(2017) DEVELOPMENTAL CELL 1534-5807 1878-1551 40 6 583-594.e6<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bordt EA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Clerc P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roelofs BA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Saladino AJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015508"><a href="/gui2/?type=authors&mode=browse&sel=10015508" target="_blank">Tretter L (<span class="authorship-author-name">Tretter László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Biokémiai Intézet">OBI</span>/MTA-SE Neurobiokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000397"><a href="/gui2/?type=authors&mode=browse&sel=10000397" target="_blank">Adam-Vizi V (<span class="authorship-author-name">Ádám Veronika</span> <span class="authorAux-mtmt"> idegtudomány, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Biokémiai Intézet">OBI</span>/MTA-SE Neurobiokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cherok E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Khalil A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yadava N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ge SX </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Francis TC </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kennedy NW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Picton LK </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kumar T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Uppuluri S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Miller AM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Itoh K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karbowski M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sesaki H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hill RB </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Polster BM </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3211755" target="_blank">The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species</a></div> <div> <span class="journal-title">DEVELOPMENTAL CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1534-5807">1534-5807</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1878-1551">1878-1551</a>)</span>: <span class="journal-volume">40</span> <span class="journal-issue">6</span> <span class="page"> pp 583-594.e6 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.devcel.2017.02.020" target="_blank" href="https://doi.org/10.1016/j.devcel.2017.02.020"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:black" title="85822" target="_blank" href="https://real.mtak.hu/85822"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="6537" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/6537"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000397386700010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000397386700010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85016487669" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85016487669"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 480</span> | Független: 468 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 475 | Scopus jelölt:&nbsp;364 | WoS/Scopus jelölt:&nbsp;480 | DOI jelölt:&nbsp;480 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3211755&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3211755</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3211755</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2020.12.22. 21:31 Szuper Admin (admin) </div> </div></div>