https://m2.mtmt.hu/ eng 2026-09-21 05:14 JournalArticle 32114882 VALIDATED true 0 false 2026-09-09T06:21:17.245+0000 2025-08-26T12:52:42.894+0000 2021-07-27T17:07:03.228+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-05-11T12:57:28.421+0000 2024-02-28T12:16:34.700+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sipos, Miklós Vitamin D Deficiency and Gender Alter Vasoconstrictor and Vasodilator Reactivity in Rat Carotid Artery true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 22 15 8029 8029 12 2021 The vitamin-D-sensitivity of the cardiovascular system may show gender differences. The prevalence of vitamin D (VD) deficiency (VDD) is high, and it alters cardiovascular function and increases the risk of stroke. Our aim was to investigate the vascular reactivity and histological changes of isolated carotid artery of female and male rats in response to different VD supplies. A total of 48 male and female Wistar rats were divided into four groups: female VD supplemented, female VDD, male VD supplemented, male VDD. The vascular function of isolated carotid artery segments was examined by wire myography. Both vitamin D deficiency and male gender resulted in increased phenylephrine-induced contraction. Acetylcholine-induced relaxation decreased in male rats independently from VD status. Inhibition of prostanoid signaling by indomethacin reduced contraction in females, but increased relaxation ability in male rats. Functional changes were accompanied by VDD and gender-specific histological alterations. Elastic fiber density was significantly decreased by VDD in female rats, but not in males. Smooth muscle actin and endothelial nitric oxide synthase levels were significantly lowered, but the thromboxane receptor was elevated in VDD males. Decreased nitrative stress was detected in both male groups independently from VD supply. The observed interactions between vitamin D deficiency and sex may play a role in the gender difference of cardiovascular risk. Funding 2001691 /api/funding/2001691 false true Funding 2001692 /api/funding/2001692 false true Funding 2010730 /api/funding/2010730 false true Funding 2010731 /api/funding/2010731 false true Funding 2010732 /api/funding/2010732 false true true true 2021 true true true false true false GOLD 2026-09-09 true https://doi.org/10.3390/ijms22158029 9 0 9 7 3 9 9 9 9 9 9 7 7 7 2 0 9 7 9 7 0 13 13 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 4 3 4 3 2023 0 1 0 1 0 2024 0 1 1 1 1 2025 0 1 1 1 1 2026 0 2 2 2 2 D1 false 10077450,10019335,10075334,10065600,10027020 false false false 2021-07-26T17:14:43.101+0000 Doktori Iskola (SE); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Orvosi Képalkotó Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 14 37 7 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96898979 /api/authorship/96898979 1 0.071 true false false Author 10077450 /api/author/10077450 Sipos Miklós true true Sipos Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898980 /api/authorship/96898980 2 0.071 false false false Author 10075334 /api/author/10075334 Gerszi Dóra true true Gerszi Dóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898981 /api/authorship/96898981 3 0.071 false false false Author 10084131 /api/author/10084131 Dalloul Hicham true true Dalloul Hicham true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898982 /api/authorship/96898982 4 0.071 false false false Author 10075180 /api/author/10075180 Bányai Bálint Péter true true Bányai Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898983 /api/authorship/96898983 5 0.071 false false true Author 10065600 /api/author/10065600 Sziva Réka Eszter true true Sziva Réka Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898984 /api/authorship/96898984 6 0.071428575 false false false Author 10095641 /api/author/10095641 Kollarics Réka true true Kollarics Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898985 /api/authorship/96898985 7 0.071 false false false Author 10023698 /api/author/10023698 Magyar Péter true 10023698 true Magyar Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898986 /api/authorship/96898986 8 0.071 false false false Author 10056811 /api/author/10056811 Török Marianna true 10056811 true Török Marianna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898987 /api/authorship/96898987 9 0.071 false false false Author 10013998 /api/author/10013998 Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898988 /api/authorship/96898988 10 0.071 false false false Author 10019335 /api/author/10019335 Szekeres Mária true 10019335 true Szekeres Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898989 /api/authorship/96898989 11 0.071 false false false Author 10023262 /api/author/10023262 Nádasy György László true 10023262 true Nádasy György L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898990 /api/authorship/96898990 12 0.071 false true Author 10027020 /api/author/10027020 Hadjadj Leila true 10027020 true Hadjadj Leila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898991 /api/authorship/96898991 13 0.071 false true false Author 10020503 /api/author/10020503 Horvath Eszter Mária true 10020503 true Horváth Eszter Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96898992 /api/authorship/96898992 14 0.071 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19045973 /api/publicationidentifier/19045973 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms22158029 https://doi.org/10.3390/ijms22158029 false true PublicationIdentifier 19090971 /api/publicationidentifier/19090971 PlainSource 1 /api/publicationsource/1 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34360792&dopt=Abstract false true SjrRating 11203857 /api/sjrrating/11203857 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1607 /api/classificationexternal/1607 true 1607 true D1 DIRECT true true /api/publication/32114882 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077450"><a href="/gui2/?type=authors&mode=browse&sel=10077450" target="_blank">Sipos Miklós (<span class="authorship-author-name">Sipos Miklós</span> <span class="authorAux-mtmt"> asszisztált reprodukció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075334"><a href="/gui2/?type=authors&mode=browse&sel=10075334" target="_blank">Gerszi Dóra (<span class="authorship-author-name">Gerszi Dóra</span> <span class="authorAux-mtmt"> szülészet - nőgyógyászat, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084131"><a href="/gui2/?type=authors&mode=browse&sel=10084131" target="_blank">Dalloul Hicham (<span class="authorship-author-name">Dalloul Hicham</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075180"><a href="/gui2/?type=authors&mode=browse&sel=10075180" target="_blank">Bányai Bálint (<span class="authorship-author-name">Bányai Bálint Péter</span> <span class="authorAux-mtmt"> Élettan, Transzlációs medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065600"><a href="/gui2/?type=authors&mode=browse&sel=10065600" target="_blank">Sziva Réka Eszter ✉ (<span class="authorship-author-name">Sziva Réka Eszter</span> <span class="authorAux-mtmt"> Szülészet-Nőgyógyászat, Nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095641"><a href="/gui2/?type=authors&mode=browse&sel=10095641" target="_blank">Kollarics Réka (<span class="authorship-author-name">Kollarics Réka</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023698"><a href="/gui2/?type=authors&mode=browse&sel=10023698" target="_blank">Magyar Péter (<span class="authorship-author-name">Magyar Péter</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056811"><a href="/gui2/?type=authors&mode=browse&sel=10056811" target="_blank">Török Marianna (<span class="authorship-author-name">Török Marianna</span> <span class="authorAux-mtmt"> élettan, szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019335"><a href="/gui2/?type=authors&mode=browse&sel=10019335" target="_blank">Szekeres Mária (<span class="authorship-author-name">Szekeres Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Health Sciences">FHS</span>/Department of Morphology and Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023262"><a href="/gui2/?type=authors&mode=browse&sel=10023262" target="_blank">Nádasy György L. (<span class="authorship-author-name">Nádasy György László</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027020"><a href="/gui2/?type=authors&mode=browse&sel=10027020" target="_blank">Hadjadj Leila<sup>**</sup> (<span class="authorship-author-name">Hadjadj Leila</span> <span class="authorAux-mtmt"> Aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth Eszter Mária<sup>**</sup> (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32114882" target="_blank">Vitamin D Deficiency and Gender Alter Vasoconstrictor and Vasodilator Reactivity in Rat Carotid Artery</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">15</span> <span class="page"> Paper 8029. 12 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms22158029" target="_blank" href="https://doi.org/10.3390/ijms22158029"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000681987100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000681987100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85111104675" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85111104675"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34360792" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34360792&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 7 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32114882&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32114882</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="funder"> (NVKP_16-1-2016-0039) Funder: NRDIO, (STIA-KF-17/24/2017) Funder: Semmelweis University Innovation Center, (K116954) Funder: NRDIO, Hungarian Hypertension Society(2015/1), Medical Faculty, Semmelweis University(2016/8) </div> <div class="lastModified">Last Modified: 2025.08.26. 14:52 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> </div></div>