https://m2.mtmt.hu/ eng 2026-10-25 19:59 JournalArticle 32110195 VALIDATED true Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, P.O. Box 67, Budapest, 1450, Hungary Laboratory of Neurobiology, Department of Zoology, Poznan University of Life Sciences, Poznan, Poland Department of Anatomy, Hokkaido University School of Medicine, Sapporo, 060-8638, Japan Department of Neuroscience, Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Doctoral School of Neurosciences “János Szentágothai”, Semmelweis University, Budapest, Hungary Cited By :5 Export Date: 4 February 2025 Correspondence Address: Kalló, I.; Laboratory of Endocrine Neurobiology, P.O. Box 67, Hungary; email: kallo@koki.hu Chemicals/CAS: gonadorelin, 33515-09-2, 9034-40-6; Endocannabinoids; Estrogens; Gonadotropin-Releasing Hormone; Kisspeptins; Receptors, Cannabinoid Funding details: 2017–59 Funding details: 2015/17/B/NZ4/02021 Funding details: Hungarian Scientific Research Fund, OTKA, K101326 Funding text 1: Open access funding provided by Semmelweis University. Support contributed by: grants from the National Science Foundation of Hungary (OTKA K101326), the Hungarian and Polish Academy of Sciences (Mobility Grant, Projekt 2017–59), and the National Science Center in Krakow, Poland (OPUS 2015/17/B/NZ4/02021 to JHS). 0 false 2026-10-21T13:24:37.282+0000 2025-01-28T13:09:46.548+0000 2021-07-22T09:07:28.945+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-05-19T11:37:46.467+0000 2026-05-19T11:37:46.467+0000 2024-12-06T17:58:54.075+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Wilheim, Tamás true true /api/journal/10006324 REVIEWED BRAIN STRUCTURE & FUNCTION 1863-2653 1863-2661 true false 10006324 false 10006324 true 1863-2653 1863-2661 Journal FOREIGN 226 2387 2399 2387 13 2021 Funding 2005055 /api/funding/2005055 K101326(Hungarian Scientific Research Fund, OTKA) false true Funding 2005056 /api/funding/2005056 OPUS 2015/17/B/NZ4/02021(National Science Center in Krakow, Poland) false true Funding 2010445 /api/funding/2010445 (Open access funding provided by Semmelweis University) false true Funding 2010446 /api/funding/2010446 (Mobility Grant, 2017–59) false true true true 2021 true true true false true false GOLD 2026-10-21 true https://doi.org/10.1007/s00429-021-02339-z 7 0 7 7 1 7 7 7 7 7 7 7 7 7 0 0 7 7 7 7 0 12 12 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 2 2 2 2023 0 2 2 2 2 2024 0 0 0 0 0 2025 0 3 3 3 3 D1 false 10068069,10011501 false false false 2021-08-09T16:12:07.598+0000 Doktori Iskola (SE); 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Balint F, Liposits Z, Farkas I (2016) Estrogen receptor beta and 2-arachidonoylglycerol mediate the suppressive effects of estradiol on frequency of postsynaptic currents in gonadotropin-releasing hormone neurons of metestrous mice: an acute slice electrophysiological study. Front Cell Neurosci 10:77. https://doi.org/10.3389/fncel.2016.00077, DOI: 10.3389/fncel.2016.00077 1 10.3389/fncel.2016.00077 false true Reference 21864895 /api/reference/21864895 2. Bardoczi Z, Wilheim T, Skrapits K, Hrabovszky E, Racz G, Matolcsy A, Liposits Z, Sliwowska JH, Dobolyi A, Kallo I (2018) GnRH neurons provide direct input to hypothalamic tyrosine hydroxylase immunoreactive neurons which is maintained during lactation. Front Endocrinol (lausanne) 9:685. https://doi.org/10.3389/fendo.2018.00685, DOI: 10.3389/fendo.2018.00685 2 10.3389/fendo.2018.00685 false true Reference 21864896 /api/reference/21864896 3. Baumgartner NE, Grissom EM, Pollard KJ, McQuillen SM, Daniel JM (2019) Neuroestrogen-dependent transcriptional activity in the brains of ERE-luciferase reporter mice following short- and long-Term ovariectomy. eNeuro 6(5). https://doi.org/10.1523/ENEURO.0275-19.2019, DOI: 10.1523/ENEURO.0275-19.2019 3 10.1523/ENEURO.0275-19.2019 false true Reference 21864897 /api/reference/21864897 4. Bosch MA, Tonsfeldt KJ, Ronnekleiv OK (2013) mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17beta-estradiol. Mol Cell Endocrinol 367(1–2):85–97. https://doi.org/10.1016/j.mce.2012.12.021, DOI: 10.1016/j.mce.2012.12.021 4 10.1016/j.mce.2012.12.021 false true Reference 21864898 /api/reference/21864898 5. Brents LK (2016) Marijuana, the endocannabinoid system and the female reproductive system. Yale J Biol Med 89(2):175–191 5 false true Reference 21864899 /api/reference/21864899 6. Chan H, Prescott M, Ong Z, Herde MK, Herbison AE, Campbell RE (2011) Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology 152(12):4906–4914. https://doi.org/10.1210/en.2011-1522, DOI: 10.1210/en.2011-1522 6 10.1210/en.2011-1522 false true Reference 21864900 /api/reference/21864900 7. Cheong RY, Czieselsky K, Porteous R, Herbison AE (2015) Expression of ESR1 in glutamatergic and gabaergic neurons is essential for normal puberty onset, estrogen feedback, and fertility in female mice. J Neurosci 35(43):14533–14543. https://doi.org/10.1523/JNEUROSCI.1776-15.2015, DOI: 10.1523/JNEUROSCI.1776-15.2015 7 10.1523/JNEUROSCI.1776-15.2015 false true Reference 21864901 /api/reference/21864901 8. Clarke IJ, Arbabi L (2016) New concepts of the central control of reproduction, integrating influence of stress, metabolic state, and season. Domest Anim Endocrinol 56(Suppl):S165-179. https://doi.org/10.1016/j.domaniend.2016.03.001, DOI: 10.1016/j.domaniend.2016.03.001 8 10.1016/j.domaniend.2016.03.001 false true Reference 21864902 /api/reference/21864902 9. Clarkson J, Herbison AE (2006) Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology 147(12):5817–5825. https://doi.org/10.1210/en.2006-0787, DOI: 10.1210/en.2006-0787 9 10.1210/en.2006-0787 false true Reference 21864903 /api/reference/21864903 10. Clarkson J, Herbison AE (2011) Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones. J Neuroendocrinol 23(4):293–301. https://doi.org/10.1111/j.1365-2826.2011.02107.x, DOI: 10.1111/j.1365-2826.2011.02107.x 10 10.1111/j.1365-2826.2011.02107.x false true Reference 21864904 /api/reference/21864904 11. Clarkson J, d’Anglemont de Tassigny X, Colledge WH, Caraty A, Herbison AE (2009) Distribution of kisspeptin neurones in the adult female mouse brain. J Neuroendocrinol 21(8):673–682. https://doi.org/10.1111/j.1365-2826.2009.01892.x, DOI: 10.1111/j.1365-2826.2009.01892.x 11 10.1111/j.1365-2826.2009.01892.x false true Reference 21864905 /api/reference/21864905 12. Comninos AN, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M, Jayasena CN, Ghatei MA, Bloom SR, Matthews PM, O’Byrne KT, Bell JD, Dhillo WS (2016) Kisspeptin signaling in the amygdala modulates reproductive hormone secretion. Brain Struct Funct 221(4):2035–2047. https://doi.org/10.1007/s00429-015-1024-9, DOI: 10.1007/s00429-015-1024-9 12 10.1007/s00429-015-1024-9 false true Reference 21864906 /api/reference/21864906 13. Cravo RM, Margatho LO, Osborne-Lawrence S, Donato J Jr, Atkin S, Bookout AL, Rovinsky S, Frazao R, Lee CE, Gautron L, Zigman JM, Elias CF (2011) Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173:37–56. https://doi.org/10.1016/j.neuroscience.2010.11.022, DOI: 10.1016/j.neuroscience.2010.11.022 13 10.1016/j.neuroscience.2010.11.022 false true Reference 21864907 /api/reference/21864907 14. DeFazio RA, Heger S, Ojeda SR, Moenter SM (2002) Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons. Mol Endocrinol 16(12):2872–2891. https://doi.org/10.1210/me.2002-0163, DOI: 10.1210/me.2002-0163 14 10.1210/me.2002-0163 false true Reference 21864908 /api/reference/21864908 15. Di S, Malcher-Lopes R, Halmos KC, Tasker JG (2003) Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci 23(12):4850–4857, DOI: 10.1523/JNEUROSCI.23-12-04850.2003 15 10.1523/JNEUROSCI.23-12-04850.2003 false true Reference 21864909 /api/reference/21864909 16. Farkas I, Kallo I, Deli L, Vida B, Hrabovszky E, Fekete C, Moenter SM, Watanabe M, Liposits Z (2010) Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. Endocrinology 151(12):5818–5829. https://doi.org/10.1210/en.2010-0638, DOI: 10.1210/en.2010-0638 16 10.1210/en.2010-0638 false true Reference 21864910 /api/reference/21864910 17. Farkas I, Balint F, Farkas E, Vastagh C, Fekete C, Liposits Z (2018) Estradiol increases glutamate and GABA neurotransmission into GnRH neurons via retrograde NO-signaling in proestrous mice during the positive estradiol feedback period. eNeuro. https://doi.org/10.1523/ENEURO.0057-18.2018, DOI: 10.1523/ENEURO.0057-18.2018 17 10.1523/ENEURO.0057-18.2018 false true Reference 21864911 /api/reference/21864911 18. Gammon CM, Freeman GM Jr, Xie W, Petersen SL, Wetsel WC (2005) Regulation of gonadotropin-releasing hormone secretion by cannabinoids. Endocrinology 146(10):4491–4499. https://doi.org/10.1210/en.2004-1672, DOI: 10.1210/en.2004-1672 18 10.1210/en.2004-1672 false true Reference 21864912 /api/reference/21864912 19. Glanowska KM, Moenter SM (2011) Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits. J Neurophysiol 106(6):3073–3081. https://doi.org/10.1152/jn.00046.2011, DOI: 10.1152/jn.00046.2011 19 10.1152/jn.00046.2011 false true Reference 21864913 /api/reference/21864913 20. Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CV, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ (2007) Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology 148(12):5752–5760. https://doi.org/10.1210/en.2007-0961, DOI: 10.1210/en.2007-0961 20 10.1210/en.2007-0961 false true Reference 21864914 /api/reference/21864914 21. Gottsch ML, Navarro VM, Zhao Z, Glidewell-Kenney C, Weiss J, Jameson JL, Clifton DK, Levine JE, Steiner RA (2009) Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci 29(29):9390–9395. https://doi.org/10.1523/JNEUROSCI.0763-09.2009, DOI: 10.1523/JNEUROSCI.0763-09.2009 21 10.1523/JNEUROSCI.0763-09.2009 false true Reference 21864915 /api/reference/21864915 22. Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Ronnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA (2011) Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology 152(11):4298–4309. https://doi.org/10.1210/en.2011-1521, DOI: 10.1210/en.2011-1521 22 10.1210/en.2011-1521 false true Reference 21864916 /api/reference/21864916 23. Hentges ST, Low MJ, Williams JT (2005) Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids. J Neurosci 25(42):9746–9751. https://doi.org/10.1523/JNEUROSCI.2769-05.2005, DOI: 10.1523/JNEUROSCI.2769-05.2005 23 10.1523/JNEUROSCI.2769-05.2005 false true Reference 21864917 /api/reference/21864917 24. Higo S, Iijima N, Ozawa H (2017) Characterisation of Kiss1r (Gpr54)-expressing neurones in the arcuate nucleus of the female rat hypothalamus. J Neuroendocrinol. https://doi.org/10.1111/jne.12452, DOI: 10.1111/jne.12452 24 10.1111/jne.12452 false true Reference 21864918 /api/reference/21864918 25. Hrabovszky E, Molnar CS, Sipos MT, Vida B, Ciofi P, Borsay BA, Sarkadi L, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Kallo I, Liposits Z (2011) Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women. Front Endocrinol (lausanne) 2:80. https://doi.org/10.3389/fendo.2011.00080, DOI: 10.3389/fendo.2011.00080 25 10.3389/fendo.2011.00080 false true Reference 21864919 /api/reference/21864919 26. Hrabovszky E, Wittmann G, Kallo I, Fuzesi T, Fekete C, Liposits Z (2012) Distribution of type 1 cannabinoid receptor-expressing neurons in the septal-hypothalamic region of the mouse: colocalization with GABAergic and glutamatergic markers. J Comp Neurol 520(5):1005–1020. https://doi.org/10.1002/cne.22766, DOI: 10.1002/cne.22766 26 10.1002/cne.22766 false true Reference 21864920 /api/reference/21864920 27. Kallo I, Vida B, Deli L, Molnar CS, Hrabovszky E, Caraty A, Ciofi P, Coen CW, Liposits Z (2012) Co-localisation of kisspeptin with galanin or neurokinin B in afferents to mouse GnRH neurones. J Neuroendocrinol 24(3):464–476. https://doi.org/10.1111/j.1365-2826.2011.02262.x, DOI: 10.1111/j.1365-2826.2011.02262.x 27 10.1111/j.1365-2826.2011.02262.x false true Reference 21864921 /api/reference/21864921 28. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE (2010) Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Neuroscience 166(2):680–697. https://doi.org/10.1016/j.neuroscience.2009.12.053, DOI: 10.1016/j.neuroscience.2009.12.053 28 10.1016/j.neuroscience.2009.12.053 false true Reference 21864922 /api/reference/21864922 29. Lehman MN, Coolen LM, Goodman RL (2010) Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 151(8):3479–3489. https://doi.org/10.1210/en.2010-0022, DOI: 10.1210/en.2010-0022 29 10.1210/en.2010-0022 false true Reference 21864923 /api/reference/21864923 30. Lehman MN, Hileman SM, Goodman RL (2013) Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol 784:27–62. https://doi.org/10.1007/978-1-4614-6199-9_3, DOI: 10.1007/978-1-4614-6199-9_3 30 10.1007/978-1-4614-6199-9_3 false true Reference 21864924 /api/reference/21864924 31. Liu X, Herbison AE (2016) Kisspeptin Regulation of neuronal activity throughout the central nervous system. Endocrinol Metab (seoul) 31(2):193–205. https://doi.org/10.3803/EnM.2016.31.2.193, DOI: 10.3803/EnM.2016.31.2.193 31 10.3803/EnM.2016.31.2.193 false true Reference 21864925 /api/reference/21864925 32. Makara JK, Katona I, Nyiri G, Nemeth B, Ledent C, Watanabe M, de Vente J, Freund TF, Hajos N (2007) Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27(38):10211–10222. https://doi.org/10.1523/JNEUROSCI.2104-07.2007, DOI: 10.1523/JNEUROSCI.2104-07.2007 32 10.1523/JNEUROSCI.2104-07.2007 false true Reference 21864926 /api/reference/21864926 33. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, Rance NE (2012) Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 153(6):2800–2812. https://doi.org/10.1210/en.2012-1045, DOI: 10.1210/en.2012-1045 33 10.1210/en.2012-1045 false true Reference 21864927 /api/reference/21864927 34. Murakawa H, Iwata K, Takeshita T, Ozawa H (2016) Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat. Neurosci Lett 612:161–166. https://doi.org/10.1016/j.neulet.2015.12.008, DOI: 10.1016/j.neulet.2015.12.008 34 10.1016/j.neulet.2015.12.008 false true Reference 21864928 /api/reference/21864928 35. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA (2009) Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 29(38):11859–11866. https://doi.org/10.1523/JNEUROSCI.1569-09.2009, DOI: 10.1523/JNEUROSCI.1569-09.2009 35 10.1523/JNEUROSCI.1569-09.2009 false true Reference 21864929 /api/reference/21864929 36. Nestor CC, Qiu J, Padilla SL, Zhang C, Bosch MA, Fan W, Aicher SA, Palmiter RD, Ronnekleiv OK, Kelly MJ (2016) Optogenetic stimulation of arcuate nucleus kiss1 neurons reveals a steroid-dependent glutamatergic input to POMC and AgRP neurons in male mice. Mol Endocrinol 30(6):630–644. https://doi.org/10.1210/me.2016-1026, DOI: 10.1210/me.2016-1026 36 10.1210/me.2016-1026 false true Reference 21864930 /api/reference/21864930 37. Nguyen QH, Wagner EJ (2006) Estrogen differentially modulates the cannabinoid- induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus. Neuroendocrinology 84(2):123–137. https://doi.org/10.1159/000096996, DOI: 10.1159/000096996 37 10.1159/000096996 false true Reference 21864931 /api/reference/21864931 38. Ohkura S, Uenoyama Y, Yamada S, Homma T, Takase K, Inoue N, Maeda K, Tsukamura H (2009) Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats. Peptides 30(1):49–56. https://doi.org/10.1016/j.peptides.2008.08.004, DOI: 10.1016/j.peptides.2008.08.004 38 10.1016/j.peptides.2008.08.004 false true Reference 21864932 /api/reference/21864932 39. Ottem EN, Godwin JG, Krishnan S, Petersen SL (2004) Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function. J Neurosci 24(37):8097–8105. https://doi.org/10.1523/JNEUROSCI.2267-04.2004, DOI: 10.1523/JNEUROSCI.2267-04.2004 39 10.1523/JNEUROSCI.2267-04.2004 false true Reference 21864933 /api/reference/21864933 40. Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R (2006) The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27(1):73–100. https://doi.org/10.1210/er.2005-0009, DOI: 10.1210/er.2005-0009 40 10.1210/er.2005-0009 false true Reference 21864934 /api/reference/21864934 41. Pineda R, Plaisier F, Millar RP, Ludwig M (2017) Amygdala kisspeptin neurons: putative mediators of olfactory control of the gonadotropic axis. Neuroendocrinology 104(3):223–238. https://doi.org/10.1159/000445895, DOI: 10.1159/000445895 41 10.1159/000445895 false true Reference 21864935 /api/reference/21864935 42. Porteous R, Petersen SL, Yeo SH, Bhattarai JP, Ciofi P, de Tassigny XD, Colledge WH, Caraty A, Herbison AE (2011) Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus. J Comp Neurol 519(17):3456–3469. https://doi.org/10.1002/cne.22716, DOI: 10.1002/cne.22716 42 10.1002/cne.22716 false true Reference 21864936 /api/reference/21864936 43. Qiu J, Nestor CC, Zhang C, Padilla SL, Palmiter RD, Kelly MJ, Ronnekleiv OK (2016) High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons. Elife. https://doi.org/10.7554/eLife.16246, DOI: 10.7554/eLife.16246 43 10.7554/eLife.16246 false true Reference 21864937 /api/reference/21864937 44. Qiu J, Rivera HM, Bosch MA, Padilla SL, Stincic TL, Palmiter RD, Kelly MJ, Ronnekleiv OK (2018) Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females. Elife. https://doi.org/10.7554/eLife.35656, DOI: 10.7554/eLife.35656 44 10.7554/eLife.35656 false true Reference 21864938 /api/reference/21864938 45. Riebe CJ, Hill MN, Lee TT, Hillard CJ, Gorzalka BB (2010) Estrogenic regulation of limbic cannabinoid receptor binding. Psychoneuroendocrinology 35(8):1265–1269. https://doi.org/10.1016/j.psyneuen.2010.02.008, DOI: 10.1016/j.psyneuen.2010.02.008 45 10.1016/j.psyneuen.2010.02.008 false true Reference 21864939 /api/reference/21864939 46. Sawai N, Iijima N, Takumi K, Matsumoto K, Ozawa H (2012) Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats. Neurosci Res 74(1):10–16. https://doi.org/10.1016/j.neures.2012.05.011, DOI: 10.1016/j.neures.2012.05.011 46 10.1016/j.neures.2012.05.011 false true Reference 21864940 /api/reference/21864940 47. Scott V, Brown CH (2013) Beyond the GnRH axis: kisspeptin regulation of the oxytocin system in pregnancy and lactation. Adv Exp Med Biol 784:201–218. https://doi.org/10.1007/978-1-4614-6199-9_10, DOI: 10.1007/978-1-4614-6199-9_10 47 10.1007/978-1-4614-6199-9_10 false true Reference 21864941 /api/reference/21864941 48. Seymour AJ, Scott V, Augustine RA, Bouwer GT, Campbell RE, Brown CH (2017) Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. J Physiol 595(3):825–838. https://doi.org/10.1113/JP273051, DOI: 10.1113/JP273051 48 10.1113/JP273051 false true Reference 21864942 /api/reference/21864942 49. Skrapits K, Borsay BA, Herczeg L, Ciofi P, Liposits Z, Hrabovszky E (2015) Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human. Front Neurosci 9:29. https://doi.org/10.3389/fnins.2015.00029, DOI: 10.3389/fnins.2015.00029 49 10.3389/fnins.2015.00029 false true Reference 21864943 /api/reference/21864943 50. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA (2005) Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146(9):3686–3692. https://doi.org/10.1210/en.2005-0488, DOI: 10.1210/en.2005-0488 50 10.1210/en.2005-0488 false true Reference 21864944 /api/reference/21864944 51. Steindel F, Lerner R, Haring M, Ruehle S, Marsicano G, Lutz B, Monory K (2013) Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. J Neurochem 124(6):795–807. https://doi.org/10.1111/jnc.12137, DOI: 10.1111/jnc.12137 51 10.1111/jnc.12137 false true Reference 21864945 /api/reference/21864945 52. Stephens SBZ, Kauffman AS (2017) Regulation and possible functions of kisspeptin in the medial amygdala. Front Endocrinol (lausanne) 8:191. https://doi.org/10.3389/fendo.2017.00191, DOI: 10.3389/fendo.2017.00191 52 10.3389/fendo.2017.00191 false true Reference 21864946 /api/reference/21864946 53. Tasker JG (2006) Rapid glucocorticoid actions in the hypothalamus as a mechanism of homeostatic integration. Obesity (silver Spring) 14(Suppl 5):259S-265S. https://doi.org/10.1038/oby.2006.320, DOI: 10.1038/oby.2006.320 53 10.1038/oby.2006.320 false true Reference 21864947 /api/reference/21864947 54. Vida B, Deli L, Hrabovszky E, Kalamatianos T, Caraty A, Coen CW, Liposits Z, Kallo I (2010) Evidence for suprachiasmatic vasopressin neurones innervating kisspeptin neurones in the rostral periventricular area of the mouse brain: regulation by oestrogen. J Neuroendocrinol 22(9):1032–1039. https://doi.org/10.1111/j.1365-2826.2010.02045.x, DOI: 10.1111/j.1365-2826.2010.02045.x 54 10.1111/j.1365-2826.2010.02045.x false true Reference 21864948 /api/reference/21864948 55. Wahab F, Atika B, Shahab M (2013) Kisspeptin as a link between metabolism and reproduction: evidences from rodent and primate studies. Metabolism 62(7):898–910. https://doi.org/10.1016/j.metabol.2013.01.015, DOI: 10.1016/j.metabol.2013.01.015 55 10.1016/j.metabol.2013.01.015 false true Reference 21864949 /api/reference/21864949 56. Williams WP 3rd, Jarjisian SG, Mikkelsen JD, Kriegsfeld LJ (2011) Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology 152(2):595–606. https://doi.org/10.1210/en.2010-0943, DOI: 10.1210/en.2010-0943 56 10.1210/en.2010-0943 false true Reference 21864950 /api/reference/21864950 57. Wintermantel TM, Campbell RE, Porteous R, Bock D, Grone HJ, Todman MG, Korach KS, Greiner E, Perez CA, Schutz G, Herbison AE (2006) Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron 52(2):271–280. https://doi.org/10.1016/j.neuron.2006.07.023, DOI: 10.1016/j.neuron.2006.07.023 57 10.1016/j.neuron.2006.07.023 false true Reference 21864951 /api/reference/21864951 58. Wittmann G, Deli L, Kallo I, Hrabovszky E, Watanabe M, Liposits Z, Fekete C (2007) Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol 503(2):270–279. https://doi.org/10.1002/cne.21383, DOI: 10.1002/cne.21383 58 10.1002/cne.21383 false true Reference 21864952 /api/reference/21864952 59. Yeo SH (2013) Neuronal circuits in the hypothalamus controlling gonadotrophin-releasing hormone release: the neuroanatomical projections of kisspeptin neurons. Exp Physiol 98(11):1544–1549. https://doi.org/10.1113/expphysiol.2013.071944, DOI: 10.1113/expphysiol.2013.071944 59 10.1113/expphysiol.2013.071944 false true Reference 21864953 /api/reference/21864953 60. Yeo SH, Herbison AE (2011) Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain. Endocrinology 152(6):2387–2399. https://doi.org/10.1210/en.2011-0164, DOI: 10.1210/en.2011-0164 60 10.1210/en.2011-0164 false true Reference 21864954 /api/reference/21864954 61. Yeo SH, Kyle V, Morris PG, Jackman S, Sinnett-Smith LC, Schacker M, Chen C, Colledge WH (2016) Visualisation of Kiss1 neurone distribution using a Kiss1-CRE transgenic mouse. J Neuroendocrinol. https://doi.org/10.1111/jne.12435, DOI: 10.1111/jne.12435 61 10.1111/jne.12435 false true Reference 21864955 /api/reference/21864955 62. Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH (2019) Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS ONE. https://doi.org/10.1371/journal.pone.0213927, DOI: 10.1371/journal.pone.0213927 62 10.1371/journal.pone.0213927 false true /api/publication/32110195 Wilheim Tamás et al. Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice. (2021) BRAIN STRUCTURE & FUNCTION 1863-2653 1863-2661 226 2387-2399<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="179"><a href="/gui2/?type=authors&mode=browse&sel=179" target="_blank">Wilheim Tamás (<span class="authorship-author-name">Wilheim Tamás</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079186"><a href="/gui2/?type=authors&mode=browse&sel=10079186" target="_blank">Nagy Krisztina (<span class="authorship-author-name">Nagy Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068069"><a href="/gui2/?type=authors&mode=browse&sel=10068069" target="_blank">Mohanraj Mahendravarman (<span class="authorship-author-name">Mohanraj Mahendravarman</span> <span class="authorAux-mtmt"> Biológus</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ziarniak Kamil </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Watanabe Masahiko </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sliwowska Joanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011501"><a href="/gui2/?type=authors&mode=browse&sel=10011501" target="_blank">Kalló Imre ✉ (<span class="authorship-author-name">Kalló Imre</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32110195" target="_blank">Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice</a></div> <div> <span class="journal-title">BRAIN STRUCTURE & FUNCTION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1863-2653">1863-2653</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1863-2661">1863-2661</a>)</span>: <span class="journal-volume">226</span> <span class="page"> pp 2387-2399 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s00429-021-02339-z" target="_blank" href="https://doi.org/10.1007/s00429-021-02339-z"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="127629" target="_blank" href="https://real.mtak.hu/127629"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000673499900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000673499900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85112274523" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85112274523"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34263407" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34263407&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Anatomy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Histology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 7 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32110195&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32110195</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> K101326(Hungarian Scientific Research Fund, OTKA), OPUS 2015/17/B/NZ4/02021(National Science Center in Krakow, Poland), (Open access funding provided by Semmelweis University), (Mobility Grant, 2017–59) </div> <div class="lastModified">Last Modified: 2025.01.28. 14:09 Tamás Pirmann (OOI addmin5, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, P.O. Box 67, Budapest, 1450, Hungary Laboratory of Neurobiology, Department of Zoology, Poznan University of Life Sciences, Poznan, Poland Department of Anatomy, Hokkaido University School of Medicine, Sapporo, 060-8638, Japan Department of Neuroscien...</pre> </div></div>