{ "labelLang" : "hun", "responseDate" : "2024-03-28 16:47", "content" : { "otype" : "JournalArticle", "mtid" : 32104504, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: Research and Technology Innovation Fund [KTIA_NAP_13-2014-0021, 2017-1.2.1-NKP-2017-00002]; Breast Cancer Research Foundation [BCRF-20-159]; Kraeftens Bekaempelse [R281-A16566]; Novo Nordisk Foundation Interdisciplinary Synergy Programme Grant [NNF15OC0016584]; Novo Nordisk Foundation Center for Protein Research [NNF14CC0001]; Department of Defense through the Prostate Cancer Research ProgramUnited States Department of Defense [W81XWH18-2-0056]; Det Frie Forskningsrad Sundhed og Sygdom [7016-00345B]; Burroughs-Wellcome FundBurroughs Wellcome Fund; NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [5K08CA219504]; Velux FoundationVelux Fonden [00018310]\n Funding text: This work was supported by the Research and Technology Innovation Fund (KTIA_NAP_13-2014-0021 and 2017-1.2.1-NKP-2017-00002 to Z. Szallasi), Breast Cancer Research Foundation (BCRF-20-159 to Z. Szallasi), Kraeftens Bekaempelse (R281-A16566 to Z. Szallasi), the Novo Nordisk Foundation Interdisciplinary Synergy Programme Grant (NNF15OC0016584 to Z. Szallasi), the Novo Nordisk Foundation Center for Protein Research core grant (NNF14CC0001 to S. Brunak), Department of Defense through the Prostate Cancer Research Program (W81XWH18-2-0056 to Z. Szallasi), Det Frie Forskningsrad Sundhed og Sygdom (7016-00345B to Z. Szallasi), Burroughs-Wellcome Fund (to K.W. Mouw), the NCI (5K08CA219504 to K.W. Mouw), and the Velux Foundation (00018310 to Z. Sztupinszki and J. B_orcs_ok). Results shown here are based in part from data generated by the TCGA Research Network: http://cancergenome.nih.gov/and the ICGC: https://icgc.org/.Results presented in the current publication are based in part on the use of study data downloaded from the dbGaP website, under phs000771.v2.p1 accession code (https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id 1/4 phs000771.v2.p1).", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2024-03-08T22:15:36.136+0000", "lastModified" : "2022-02-01T14:18:50.324+0000", "created" : "2021-07-16T09:58:05.922+0000", "creator" : { "otype" : "Admin", "mtid" : 10062250, "link" : "/api/admin/10062250", "label" : "Molnár-Taga Márta (SE 4-es admin)", "familyName" : "Molnár-Taga", "givenName" : "Márta", "published" : true, "oldId" : 10062250, "snippet" : true }, "lastDuplumSearch" : "2023-07-07T11:31:35.933+0000", "validated" : "2022-02-01T14:16:30.364+0000", "validator" : { "otype" : "Admin", "mtid" : 10062723, "link" : "/api/admin/10062723", "label" : "Nikolics Erzsébet (SE_KK_Admin5_NE, admin)", "familyName" : "Nikolics", "givenName" : "Erzsébet", "published" : true, "oldId" : 10062723, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Börcsök, J.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 96830172, "link" : "/api/authorship/96830172", "label" : "Börcsök, J.", "listPosition" : 1, "share" : 0.07692308, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Börcsök", "givenName" : "J.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830173, "link" : "/api/authorship/96830173", "label" : "Diossy, M.", "listPosition" : 2, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Diossy", "givenName" : "M.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830174, "link" : "/api/authorship/96830174", "label" : "Sztupinszki, Z.", "listPosition" : 3, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Sztupinszki", "givenName" : "Z.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830175, "link" : "/api/authorship/96830175", "label" : "Prosz, A.", "listPosition" : 4, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Prosz", "givenName" : "A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830176, "link" : "/api/authorship/96830176", "label" : "Tisza, Viktória [Tisza, Viktoria (molekularis biologia), szerző]", "listPosition" : 5, "share" : 0.077, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10082012, "link" : "/api/author/10082012", "label" : "Tisza Viktoria (molekularis biologia)", "familyName" : "Tisza", "givenName" : "Viktoria", "published" : true, "snippet" : true }, "familyName" : "Tisza", "givenName" : "Viktória", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830177, "link" : "/api/authorship/96830177", "label" : "Spisak, S. [Spisák, Sándor (Molekuláris genetika), szerző]", "listPosition" : 6, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10038807, "link" : "/api/author/10038807", "label" : "Spisák Sándor (Molekuláris genetika)", "familyName" : "Spisák", "givenName" : "Sándor", "published" : true, "oldId" : 10038807, "snippet" : true }, "familyName" : "Spisak", "givenName" : "S.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830178, "link" : "/api/authorship/96830178", "label" : "Rusz, O.", "listPosition" : 7, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Rusz", "givenName" : "O.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830179, "link" : "/api/authorship/96830179", "label" : "Stormoen, D.R.", "listPosition" : 8, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Stormoen", "givenName" : "D.R.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830180, "link" : "/api/authorship/96830180", "label" : "Pappot, H.", "listPosition" : 9, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Pappot", "givenName" : "H.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830181, "link" : "/api/authorship/96830181", "label" : "Csabai, I.", "listPosition" : 10, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Csabai", "givenName" : "I.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830182, "link" : "/api/authorship/96830182", "label" : "Brunak, S.", "listPosition" : 11, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Brunak", "givenName" : "S.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830183, "link" : "/api/authorship/96830183", "label" : "Mouw, K.W.", "listPosition" : 12, "share" : 0.07692308, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mouw", "givenName" : "K.W.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 96830184, "link" : "/api/authorship/96830184", "label" : "Szallasi, Z. ✉ [Szállási, Zoltán (Onkológia, dagana...), szerző] II. Sz. Patológiai Intézet (SE / AOK / I); MTA-SE-NAP B Agymetasztázis Kutatócsoport (SE / AOK / I / IISZPI)", "listPosition" : 13, "share" : 0.077, "first" : false, "last" : true, "corresponding" : true, "author" : { "otype" : "Author", "mtid" : 10068108, "link" : "/api/author/10068108", "label" : "Szállási Zoltán (Onkológia, daganatkutatás)", "familyName" : "Szállási", "givenName" : "Zoltán", "published" : true, "snippet" : true }, "familyName" : "Szallasi", "givenName" : "Z.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Detection of molecular signatures of homologous recombination deficiency in bladder cancer", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 19018370, "link" : "/api/publicationidentifier/19018370", "label" : "DOI: 10.1158/1078-0432.CCR-20-5037", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "PAY", "validState" : "IDENTICAL", "idValue" : "10.1158/1078-0432.CCR-20-5037", "realUrl" : "https://doi.org/10.1158/1078-0432.CCR-20-5037", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 19044675, "link" : "/api/publicationidentifier/19044675", "label" : "WoS: 000670550600028", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000670550600028", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000670550600028", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 19018369, "link" : "/api/publicationidentifier/19018369", "label" : "Scopus: 85109143213", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85109143213", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85109143213", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 19018371, "link" : "/api/publicationidentifier/19018371", "label" : "PubMed: 33947694", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "33947694", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33947694&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 1405637, "link" : "/api/journal/1405637", "label" : "CLINICAL CANCER RESEARCH 1078-0432 1557-3265", "pIssn" : "1078-0432", "eIssn" : "1557-3265", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 1405637, "snippet" : true }, "volume" : "27", "issue" : "13", "firstPage" : "3734", "lastPage" : "3743", "firstPageOrInternalIdForSort" : "3734", "pageLength" : 10, "publishedYear" : 2021, "abstractText" : "Purpose: Poly (ADP ribose)-polymerase (PARP) inhibitors are approvedforuseinbreast,ovarian,prostate,andpancreaticcancers, which are the solid tumor types that most frequently have alterations in key homologous recombination (HR) genes, such as BRCA1/2. However, the frequency of HR deficiency (HRD) in other solid tumor types, including bladder cancer, is less well characterized. Experimental Design: Specific DNA aberration profiles (mutational signatures) are induced by HRD, and the presence of these “genomic scars” can be used to assess the presence or absence of HRD in a given tumor biopsy even in the absence of an observed alteration of an HR gene. Using whole-exome and whole-genome data, we measured various HRD-associated mutational signatures in bladder cancer. Results: We found that a subset of bladder tumors have evidence of HRD. In addition to a small number of tumors with biallelic BRCA1/2 events, approximately 10% of bladder tumors had significant evidence of HRD-associated mutational signatures. Increased levels of HRD signatures were associated with promoter methylation of RBBP8, which encodes CtIP, a key protein involved in HR. Conclusions: A subset of bladder tumors have genomic features suggestive of HRD and therefore may be more likely to benefit from therapies such as platinum agents and PARP inhibitors that target tumor HRD. © 2021 American Association for Cancer Research.", "fundings" : [ { "otype" : "Funding", "mtid" : 2007922, "link" : "/api/funding/2007922", "label" : "(KTIA_NAP_13-2014-0021)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 2007923, "link" : "/api/funding/2007923", "label" : "Hungarian Brain Research Program(2017-1.2.1-NKP-2017-00002) Támogató: NKFIH", "published" : false, "snippet" : true } ], "digital" : true, "printed" : true, "sourceYear" : 2021, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "PAY", "oaCheckDate" : "2024-03-08", "oaFree" : false, "citationCount" : 17, "citationCountUnpublished" : 0, "citationCountWoOther" : 17, "independentCitCountWoOther" : 15, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 16, "doiCitationCount" : 16, "wosCitationCount" : 14, "scopusCitationCount" : 17, "wosScopusCitationCount" : 17, "wosScopusCitationCountWoOther" : 17, "wosScopusIndependentCitationCount" : 15, "wosScopusIndependentCitationCountWoOther" : 15, "independentCitationCount" : 15, "selfCitationCount" : 2, "unhandledCitationCount" : 0, "citingPubCount" : 17, "independentCitingPubCount" : 15, "citingPubCountWoOther" : 17, "independentCitingPubCountWoOther" : 15, "unhandledCitingPubCount" : 0, "citedPubCount" : 8, "citedCount" : 8, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 17 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 2021, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 6, "independentCitationCount" : 5, "citingPubCount" : 6, "independentCitingPubCount" : 5, "oaStats" : null, "oaStats2" : null }, { "year" : 2023, "publicationCount" : 0, "citationCount" : 6, "independentCitationCount" : 6, "citingPubCount" : 6, "independentCitingPubCount" : 6, "oaStats" : null, "oaStats2" : null }, { "year" : 2024, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11197022, "link" : "/api/sjrrating/11197022", "label" : "sjr:D1 (2021) Scopus - Cancer Research CLINICAL CANCER RESEARCH 1078-0432 1557-3265", "listPos" : 10, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1306, "link" : "/api/classificationexternal/1306", "label" : "Scopus - Cancer Research", "published" : true, "oldId" : 1306, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "references" : [ { "otype" : "Reference", "mtid" : 21780837, "link" : "/api/reference/21780837", "label" : "1. Sonpavde, G, Watson, D, Tourtellott, M, Cowey, CL, Hellerstedt, B, Hutson, TE, Administration of cisplatin-based chemotherapy for advanced urothelial carcinoma in the community (2012) Clin Genitourin Cancer, 10, pp. 1-5", "listPosition" : 1, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780835, "link" : "/api/reference/21780835", "label" : "2. Hussain, SA, James, ND., The systemic treatment of advanced and metastatic bladder cancer (2003) Lancet Oncol, 4, pp. 489-497", "listPosition" : 2, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780834, "link" : "/api/reference/21780834", "label" : "3. Przetocka, S, Porro, A, Bolck, HA, Walker, C, Lezaja, A, Trenner, A, CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress (2018) Mol Cell, 72, pp. 568-582. , e6", "listPosition" : 3, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780833, "link" : "/api/reference/21780833", "label" : "4. Zarrizi, R, Higgs, MR, Voßgr€one, K, Rossing, M, Bertelsen, B, Bose, M, Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability (2020) J Clin Invest, 130, pp. 4069-4080", "listPosition" : 4, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780832, "link" : "/api/reference/21780832", "label" : "5. Wang, J, Ding, Q, Fujimori, H, Motegi, A, Miki, Y, Masutani, M., Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors (2016) Oncotarget, 7, pp. 7701-7714", "listPosition" : 5, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780831, "link" : "/api/reference/21780831", "label" : "6. Yun, MH, Hiom, K., CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle (2009) Nature, 459, pp. 460-463", "listPosition" : 6, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780830, "link" : "/api/reference/21780830", "label" : "7. Mijnes, J, Veeck, J, Gaisa, NT, Burghardt, E, de Ruijter, TC, Gostek, S, Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer (2018) Clin Epigenetics, 10, p. 15", "listPosition" : 7, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780829, "link" : "/api/reference/21780829", "label" : "8. Polak, P, Kim, J, Braunstein, LZ, Karlic, R, Haradhavala, NJ, Tiao, G, A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer (2017) Nat Genet, 49, pp. 1476-1486", "listPosition" : 8, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780828, "link" : "/api/reference/21780828", "label" : "9. Alexandrov, LB, Nik-Zainal, S, Wedge, DC, Aparicio, SAJR, Behjati, S, Biankin, AV, Signatures of mutational processes in human cancer (2013) Nature, 500, pp. 415-421", "listPosition" : 9, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780827, "link" : "/api/reference/21780827", "label" : "10. [cited 2020 Jul 30]", "listPosition" : 10, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780826, "link" : "/api/reference/21780826", "label" : "11. (2019), https://www.fda.gov/medical-devices/recently-approved-devices/myriad-mychoice-cdx-p190014, Health C for D and R Myriad myChoice CDx. P190014. FDA [Internet]. FDA", "listPosition" : 11, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780825, "link" : "/api/reference/21780825", "label" : "12. Birkbak, NJ, Wang, ZC, Kim, J-Y, Eklund, AC, Li, Q, Tian, R, Telomeric allelic imbalance indicates defective DNA-repair and sensitivity to DNA-damaging agents (2012) Cancer Discov, 2, pp. 366-375", "listPosition" : 12, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780824, "link" : "/api/reference/21780824", "label" : "13. Popova, T, Manie, E, Rieunier, G, Caux-Moncoutier, V, Tirapo, C, Dubois, T, Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation (2012) Cancer Res, 72, pp. 5454-5462", "listPosition" : 13, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780823, "link" : "/api/reference/21780823", "label" : "14. Abkevich, V, Timms, KM, Hennessy, BT, Potter, J, Carey, MS, Meyer, LA, Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer (2012) Br J Cancer, 107, pp. 1776-1782", "listPosition" : 14, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780822, "link" : "/api/reference/21780822", "label" : "15. Mutter, RW, Riaz, N, Ng, CK, Delsite, R, Piscuoglio, S, Edelweiss, M, Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer (2017) J Pathol, 242, pp. 165-177", "listPosition" : 15, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780821, "link" : "/api/reference/21780821", "label" : "16. Li, A, Geyer, FC, Blecua, P, Lee, JY, Selenica, P, Brown, DN, Homologous recombination DNA repair defects in PALB2-associated breast cancers (2019) NPJ Breast Cancer, 5, p. 23", "listPosition" : 16, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780820, "link" : "/api/reference/21780820", "label" : "17. Sakai, W, Swisher, EM, Jacquemont, C, Chandramohan, KV, Couch, FJ, Langdon, SP, Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma (2009) Cancer Res, 69, pp. 6381-6386", "listPosition" : 17, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780819, "link" : "/api/reference/21780819", "label" : "18. Kandoth, C, McLellan, MD, Vandin, F, Ye, K, Niu, B, Lu, C, Mutational landscape and significance across 12 major cancer types (2013) Nature, 502, pp. 333-339", "listPosition" : 18, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780818, "link" : "/api/reference/21780818", "label" : "19. Sztupinszki, Z, Diossy, M, Krzystanek, M, Borcsok, J, Pomerantz, MM, Tisza, V, Detection of molecular signatures of homologous recombination deficiency in prostate cancer with or without BRCA1/2 mutations (2020) Clin Cancer Res, 26, pp. 2673-2680", "listPosition" : 19, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780817, "link" : "/api/reference/21780817", "label" : "20. Iorio, F, Knijnenburg, TA, Vis, DJ, Bignell, GR, Menden, MP, Schubert, M, A landscape of pharmacogenomic interactions in cancer (2016) Cell, 166, pp. 740-754", "listPosition" : 20, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780816, "link" : "/api/reference/21780816", "label" : "21. Seashore-Ludlow, B, Rees, MG, Cheah, JH, Cokol, M, Price, EV, Coletti, ME, Harnessing connectivity in a large-scale small-molecule sensitivity dataset (2015) Cancer Discov, 5, pp. 1210-1223", "listPosition" : 21, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780815, "link" : "/api/reference/21780815", "label" : "22. Smirnov, P, Safikhani, Z, El-Hachem, N, Wang, D, She, A, Olsen, C, PharmacoGx: an R package for analysis of large pharmacogenomic datasets (2016) Bioinformatics, 32, pp. 1244-1246", "listPosition" : 22, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780814, "link" : "/api/reference/21780814", "label" : "23. Ghandi, M, Huang, FW, Jane-Valbuena, J, Kryukov, GV, Lo, CC, McDonald, ER, Next-generation characterization of the cancer cell line encyclopedia (2019) Nature, 569, pp. 503-508", "listPosition" : 23, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780813, "link" : "/api/reference/21780813", "label" : "24. Meyers, RM, Bryan, JG, McFarland, JM, Weir, BA, Sizemore, AE, Xu, H, Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells (2017) Nat Genet, 49, pp. 1779-1784", "listPosition" : 24, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780812, "link" : "/api/reference/21780812", "label" : "25. Aryee, MJ, Jaffe, AE, Corrada-Bravo, H, Ladd-Acosta, C, Feinberg, AP, Hansen, KD, Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays (2014) Bioinformatics, 30, pp. 1363-1369", "listPosition" : 25, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780811, "link" : "/api/reference/21780811", "label" : "26. Goldman, MJ, Craft, B, Hastie, M, Repecka, K, McDade, F, Kamath, A, Visualizing and interpreting cancer genomics data via the xena platform (2020) Nat Biotechnol, 38, pp. 675-678", "listPosition" : 26, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780810, "link" : "/api/reference/21780810", "label" : "27. Sztupinszki, Z, Diossy, M, Krzystanek, M, Reiniger, L, Csabai, I, Favero, F, Migrating the SNP array-based homologous recombination deficiency measures to next generation sequencing data of breast cancer (2018) NPJ Breast Cancer, 4, p. 16", "listPosition" : 27, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780809, "link" : "/api/reference/21780809", "label" : "28. Nik-Zainal, S, Davies, H, Staaf, J, Ramakrishna, M, Glodzik, D, Zou, X, Landscape of somatic mutations in 560 breast cancer whole-genome sequences (2016) Nature, 534, pp. 47-54", "listPosition" : 28, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780808, "link" : "/api/reference/21780808", "label" : "29. Alexandrov, LB, Kim, J, Haradhvala, NJ, Huang, MN, Tian Ng, AW, Wu, Y, The repertoire of mutational signatures in human cancer (2020) Nature, 578, pp. 94-101", "listPosition" : 29, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780807, "link" : "/api/reference/21780807", "label" : "30. Boot, A, Huang, MN, Ng, AWT, Ho, S-C, Lim, JQ, Kawakami, Y, In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors (2018) Genome Res, 28, pp. 654-665", "listPosition" : 30, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780806, "link" : "/api/reference/21780806", "label" : "31. Rosenthal, R, McGranahan, N, Herrero, J, Taylor, BS, Swanton, C., DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution (2016) Genome Biol, 17, p. 31", "listPosition" : 31, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780805, "link" : "/api/reference/21780805", "label" : "32. Li, Q, Wang, K., InterVar: clinical interpretation of genetic variants by the 2015 ACMG-AMP guidelines (2017) Am J Hum Genet, 100, pp. 267-280", "listPosition" : 32, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780804, "link" : "/api/reference/21780804", "label" : "33. Shen, R, Seshan, VE., FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing (2016) Nucleic Acids Res, 44, p. e131", "listPosition" : 33, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780803, "link" : "/api/reference/21780803", "label" : "34. Favero, F, Joshi, T, Marquard, AM, Birkbak, NJ, Krzystanek, M, Li, Q, Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data (2015) Ann Oncol, 26, pp. 64-70", "listPosition" : 34, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780802, "link" : "/api/reference/21780802", "label" : "35. Zhao, EY, Shen, Y, Pleasance, E, Kasaian, K, Leelakumari, S, Jones, M, Homologous recombination deficiency and platinum-based therapy outcomes in advanced breast cancer (2017) Clin Cancer Res, 23, pp. 7521-7530", "listPosition" : 35, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780801, "link" : "/api/reference/21780801", "label" : "36. Ray-Coquard, I, Pautier, P, Pignata, S, Perol, D, Gonzalez-Martín, A, Berger, R, Olaparib plus bevacizumab as first-line maintenance in ovarian cancer (2019) N Engl J Med, 381, pp. 2416-2428", "listPosition" : 36, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780800, "link" : "/api/reference/21780800", "label" : "37. Davies, H, Glodzik, D, Morganella, S, Yates, LR, Staaf, J, Zou, X, HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures (2017) Nat Med, 23, pp. 517-525", "listPosition" : 37, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780799, "link" : "/api/reference/21780799", "label" : "38. Telli, ML, Timms, KM, Reid, J, Hennessy, B, Mills, GB, Jensen, KC, Homologous recombination deficiency (HRD) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer (2016) Clin Cancer Res, 22, pp. 3764-3773", "listPosition" : 38, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780798, "link" : "/api/reference/21780798", "label" : "39. Poti, A, Gyergyak, H, Nemeth, E, Rusz, O, Toth, S, Kovacshazi, C, Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents (2019) Genome Biol, 20, p. 240", "listPosition" : 39, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780797, "link" : "/api/reference/21780797", "label" : "40. Grivas, P, Loriot, Y, Feyerabend, S, Morales-Barrera, R, Teo, MY, Vogelzang, NJ, Rucaparib for recurrent, locally advanced, or metastatic urothelial carcinoma (mUC): results from ATLAS, a phase II open-label trial (2020) J Clin Oncol, 38 (6), p. 440. , (Suppl)", "listPosition" : 40, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780796, "link" : "/api/reference/21780796", "label" : "41. Taber, A, Christensen, E, Lamy, P, Nordentoft, I, Prip, F, Lindskrog, SV, Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis (2020) Nat Commun, 11, p. 4858", "listPosition" : 41, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780795, "link" : "/api/reference/21780795", "label" : "42. Iyer, G, Balar, AV, Milowsky, MI, Bochner, BH, Dalbagni, G, Donat, SM, Multicenter prospective phase II trial of neoadjuvant dose-dense gemcitabine plus cisplatin in patients with muscle-invasive bladder cancer (2018) J Clin Oncol, 36, pp. 1949-1956", "listPosition" : 42, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780794, "link" : "/api/reference/21780794", "label" : "43. Teo, MY, Bambury, RM, Zabor, EC, Jordan, E, Al-Ahmadie, H, Boyd, ME, DNA damage response and repair gene alterations are associated with improved survival in patients with platinum-treated advanced urothelial carcinoma (2017) Clin Cancer Res, 23, pp. 3610-3618", "listPosition" : 43, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780793, "link" : "/api/reference/21780793", "label" : "44. Miron, B, Hoffman-Censits, JH, Anari, F, O’Neill, J, Geynisman, DM, Zibelman, MR, Defects in DNA repair genes confer improved long-term survival after cisplatin-based neoadjuvant chemotherapy for muscle-invasive bladder cancer (2020) Eur Urol Oncol, 3, pp. 544-547", "listPosition" : 44, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780792, "link" : "/api/reference/21780792", "label" : "45. Bolton, KL, Chenevix-Trench, G, Goh, C, Sadetzki, S, Ramus, SJ, Karlan, BY, Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer (2012) JAMA, 307, pp. 382-390", "listPosition" : 45, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780791, "link" : "/api/reference/21780791", "label" : "46. Silver, DP, Richardson, AL, Eklund, AC, Wang, ZC, Szallasi, Z, Li, Q, Efficacy of neoadjuvant cisplatin in triple-negative breast cancer (2010) J Clin Oncol, 28, pp. 1145-1153", "listPosition" : 46, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780790, "link" : "/api/reference/21780790", "label" : "47. B€orcs€ok, J, Sztupinszki, Z, Bekele, R, Gao, SP, Diossy, M, Samant, AS, Identification of a synthetic lethal relationship between nucleotide excision repair (NER) deficiency and irofulven sensitivity in urothelial cancer (2021) Clin Cancer Res, 27, pp. 2011-2022", "listPosition" : 47, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780789, "link" : "/api/reference/21780789", "label" : "48. Comprehensive molecular characterization of urothelial bladder carcinoma (2014) Nature, 507, pp. 315-322. , Cancer Genome Atlas Research Network", "listPosition" : 48, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780788, "link" : "/api/reference/21780788", "label" : "49. Liu, D, Plimack, ER, Hoffman-Censits, J, Garraway, LA, Bellmunt, J, Van Allen, E, Clinical validation of chemotherapy response biomarker ERCC2 in muscle-invasive urothelial bladder carcinoma (2016) JAMA Oncol, 2, pp. 1094-1096", "listPosition" : 49, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780787, "link" : "/api/reference/21780787", "label" : "50. Van Allen, EM, Mouw, KW, Kim, P, Iyer, G, Wagle, N, Al-Ahmadie, H, Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma (2014) Cancer Discov, 4, pp. 1140-1153", "listPosition" : 50, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780786, "link" : "/api/reference/21780786", "label" : "51. Perez-Gracia, JL, Loriot, Y, Rosenberg, JE, Powles, T, Necchi, A, Hussain, SA, Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: outcomes by prior number of regimens (2018) Eur Urol, 73, pp. 462-468", "listPosition" : 51, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21780836, "link" : "/api/reference/21780836", "label" : "52. Mirza, MR, Monk, BJ, Herrstedt, J, Oza, AM, Mahner, S, Redondo, A, Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer (2016) N Engl J Med, 375, pp. 2154-2164", "listPosition" : 52, "published" : false, "snippet" : true } ], "hasCitationDuplums" : false, "inSelectedPubs" : "10068108,10082012", "userChangeableUntil" : "2021-07-15T10:03:39.967+0000", "directInstitutesForSort" : "II. Sz. Patológiai Intézet (SE / AOK / I); MTA-SE-NAP B Agymetasztázis Kutatócsoport (SE / AOK / I / IISZPI)", "ownerAuthorCount" : 3, "ownerInstituteCount" : 19, "directInstituteCount" : 2, "authorCount" : 13, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/32104504", "label" : "Börcsök J. et al. Detection of molecular signatures of homologous recombination deficiency in bladder cancer. (2021) CLINICAL CANCER RESEARCH 1078-0432 1557-3265 27 13 3734-3743", "template" : "