The MM500 study is an initiative to map the protein levels in malignant melanoma tumor
samples, focused on in‐depth histopathology coupled to proteome characterization.
The protein levels and localization were determined for a broad spectrum of diverse,
surgically isolated melanoma tumors originating from multiple body locations. More
than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal
and subcellular localization was annotated within both primary and metastatic melanoma.
The data generated by global proteomic experiments covered 72% of the proteins identified
in the recently reported high stringency blueprint of the human proteome. This study
contributes to the NIH Cancer Moonshot initiative combining detailed histopathological
presentation with the molecular characterization for 505 melanoma tumor samples, localized
in 26 organs from 232 patients.
