https://m2.mtmt.hu/ eng 2026-05-26 07:15 JournalArticle 32084409 VALIDATED true Funding Agency and Grant Number: National Institutes of Health/National Institute of Dental and Craniofacial Research Grant [1R21 DE14583]; Oklahoma Applied Research Support (OARS) award from the Oklahoma Center for Science and Technology (OCAST) [AR071-035]; PreDENT LLC; Hungarian Human Resources Development Operational Program [EFOP-3.6.2-16-2017-00006]; Thematic Excellence Programme of the Ministry for Innovation and Technology in Hungary at the Semmelweis University [2020-4.1.1.TKP2020] Funding text: M.L. was supported by a National Institutes of Health/National Institute of Dental and Craniofacial Research Grant 1R21 DE14583, an Oklahoma Applied Research Support (OARS) award AR071-035 from the Oklahoma Center for Science and Technology (OCAST) and matching funds from PreDENT LLC. Z.M.L. was supported by the Hungarian Human Resources Development Operational Program (grant no. EFOP-3.6.2-16-2017-00006), and the Thematic Excellence Programme (2020-4.1.1.TKP2020) of the Ministry for Innovation and Technology in Hungary within the framework of the Therapy thematic programme at the Semmelweis University. Export Date: 14 September 2021 Correspondence Address: Levine, M.; Department of Biochemistry and Molecular Biology, United States; email: martin-levine@ouhsc.edu Export Date: 16 September 2021 Correspondence Address: Levine, M.; Department of Biochemistry and Molecular Biology, United States; email: martin-levine@ouhsc.edu Export Date: 17 September 2021 Correspondence Address: Levine, M.; Department of Biochemistry and Molecular Biology, United States; email: martin-levine@ouhsc.edu 0 false 2026-05-20T23:09:11.290+0000 2022-01-25T15:00:49.415+0000 2021-06-29T12:08:40.595+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin true 10018804 5390381 2026-02-05T20:12:54.861+0000 2026-02-05T20:12:54.981+0000 Admin 10018804 /api/admin/10018804 Szalóky-Siki Ágnes true 10018804 true SUSPECT 2025-01-03T20:57:52.046+0000 2026-02-05T20:12:54.981+0000 2021-07-05T15:06:35.362+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Levine, Martin Resolving the Contradictory Functions of Lysine Decarboxylase and Butyrate in Periodontal and Intestinal Diseases true true /api/journal/10017543 REVIEWED true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 10 11 2360 2360 27 2021 Periodontal disease is a common, bacterially mediated health problem worldwide. Mastication (chewing) repeatedly traumatizes the gingiva and periodontium, causing traces of inflammatory exudate, gingival crevicular fluid (GCF), to appear in crevices between the teeth and gingiva. Inadequate tooth cleaning causes a dentally adherent microbial biofilm composed of commensal salivary bacteria to appear around these crevices where many bacteria grow better on GCF than in saliva. We reported that lysine decarboxylase (Ldc) from Eikenella corrodens depletes the GCF of lysine by converting it to cadaverine and carbon dioxide. Lysine is an amino acid essential for the integrity and continuous renewal of dentally attached epithelium acting as a barrier to microbial products. Unless removed regularly by oral hygiene, bacterial products invade the lysine-deprived dental attachment where they stimulate inflammation that enhances GCF exudation. Cadaverine increases and supports the development of a butyrate-producing microbiome that utilizes the increased GCF substrates to slowly destroy the periodontium (dysbiosis). A long-standing paradox is that acid-induced Ldc and butyrate production support a commensal (probiotic) microbiome in the intestine. Here, we describe how the different physiologies of the respective tissues explain how the different Ldc and butyrate functions impact the progression and control of these two chronic diseases. 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<span class="author-name" mtid="10018912"><a href="/gui2/?type=authors&mode=browse&sel=10018912" target="_blank">Lohinai Zsolt M (<span class="authorship-author-name">Lohinai Zsolt</span> <span class="authorAux-mtmt"> Konzerváló fogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Conservative Dentistry</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32084409" target="_blank">Resolving the Contradictory Functions of Lysine Decarboxylase and Butyrate in Periodontal and Intestinal Diseases</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">11</span> <span class="page"> Paper 2360. 27 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm10112360" target="_blank" href="https://doi.org/10.3390/jcm10112360"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000660179100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000660179100001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8989" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8989"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85114071234" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85114071234"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34072136" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34072136&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 11 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32084409&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32084409</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing Suspect | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO, Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology </div> <div class="duplumMark">Duplum marked: 2026.02.05. 21:12 (Ágnes Szalóky-Siki (SE_FOK_Admin5_SIKIÁ, admin)) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/32084409/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2022.01.25. 16:00 Lilian Vasvari (MTMT Központ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Institutes of Health/National Institute of Dental and Craniofacial Research Grant [1R21 DE14583]; Oklahoma Applied Research Support (OARS) award from the Oklahoma Center for Science and Technology (OCAST) [AR071-035]; PreDENT LLC; Hungarian Human Resources Development Operational Program [EFOP-3.6.2-16-2017-00006]; Thematic Excellence Programme of the M...</pre> </div></div>