https://m2.mtmt.hu/ eng 2026-06-24 04:40 JournalArticle 32082857 APPROVED true 0 false 2026-06-14T00:27:43.924+0000 2026-04-20T11:08:26.495+0000 2021-06-28T12:32:12.330+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin Anna Berhidi (SE_KK_Admin5_BA, admin) true 10015546 2026-04-20T11:12:05.141+0000 2026-04-20T11:12:00.428+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Menyhart, O. true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 16 6 0245824 0245824 12 2021 Scientists from nearly all disciplines face the problem of simultaneously evaluating many hypotheses. Conducting multiple comparisons increases the likelihood that a non-negligible proportion of associations will be false positives, clouding real discoveries. Drawing valid conclusions require taking into account the number of performed statistical tests and adjusting the statistical confidence measures. Several strategies exist to overcome the problem of multiple hypothesis testing. We aim to summarize critical statistical concepts and widely used correction approaches while also draw attention to frequently misinterpreted notions of statistical inference. We provide a step-by-step description of each multiple-testing correction method with clear examples and present an easy-to-follow guide for selecting the most suitable correction technique. To facilitate multiple-testing corrections, we developed a fully automated solution not requiring programming skills or the use of a command line. Our registration free online tool is available at www.multipletesting.com and compiles the five most frequently used adjustment tools, including the Bonferroni, the Holm (step-down), the Hochberg (step-up) corrections, allows to calculate False Discovery Rates (FDR) and q-values. The current summary provides a much needed practical synthesis of basic statistical concepts regarding multiple hypothesis testing in a comprehensible language with well-illustrated examples. The web tool will fill the gap for life science researchers by providing a user-friendly substitute for command-line alternatives. © 2021 Public Library of Science. All rights reserved. Funding 2007702 /api/funding/2007702 Magyar-koreai kutatás-fejlesztési együttműködési pályázat(2018-2.1.17-TÉT-KR-00001) Funder: NKFIH false true Funding 2007703 /api/funding/2007703 (2020-1.1.6-JOVO-2021-00013) false true Funding 2007704 /api/funding/2007704 (2018-1.3.1-VKE-2018-00032) false true Funding 2007705 /api/funding/2007705 Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology false true true 2021 true true true false true false GOLD 2026-06-14 true https://doi.org/10.1371/journal.pone.0245824 148 0 148 139 11 148 148 145 102 148 148 139 139 139 9 0 148 139 148 139 0 0 0 Folyóiratcikk Journal Article 24 147 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 4 4 4 4 2022 0 18 16 18 16 2023 0 25 23 25 23 2024 0 34 32 34 32 2025 0 47 45 47 45 2026 0 20 19 20 19 Q1 A false 10045338 false false false 2021-06-27T12:38:26.386+0000 Bioinformatika Tanszék (SE / AOK / I); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 3 27 3 3 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 96694269 /api/authorship/96694269 Menyhart, O. [Menyhart, Otilia (onkologia), author] Enzim_417 (IMLS); Bioinformatika Tanszék (SU / FM / I) 1 0.333 true false false Author 10045338 /api/author/10045338 Otilia Menyhart (onkologia) Menyhart Otilia true 10045338 true Menyhart O. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96694270 /api/authorship/96694270 Weltz, B. [Bernhardt-Weltz, Boglárka (Bioinformatika), author] Bioinformatika Tanszék (SU / FM / I) 2 0.333 false false false Author 10105035 /api/author/10105035 Boglárka Bernhardt-Weltz (Bioinformatika) Bernhardt-Weltz Boglárka true true Weltz B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96694271 /api/authorship/96694271 Gyorffy, B. ✉ [Győrffy, Balázs (Onkológia), author] II. Department of Pediatrics (SU / FM / C); Enzim_417 (IMLS); Bioinformatika Tanszék (SU / FM / I) 3 0.333 false true true Author 10000109 /api/author/10000109 Balázs Győrffy (Onkológia) Győrffy Balázs true 10000109 true Gyorffy B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 18957653 /api/publicationidentifier/18957653 DOI: 10.1371/journal.pone.0245824 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0245824 https://doi.org/10.1371/journal.pone.0245824 false true PublicationIdentifier 19065619 /api/publicationidentifier/19065619 WoS: 000664642200006 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000664642200006 https://www.webofscience.com/wos/woscc/full-record/000664642200006 true true PublicationIdentifier 18957652 /api/publicationidentifier/18957652 Scopus: 85107814325 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85107814325 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85107814325 false true PublicationIdentifier 18957654 /api/publicationidentifier/18957654 PubMed: 34106935 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34106935 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34106935&dopt=Abstract false true Keyword 1699 /api/keyword/1699 ARTICLE true 1699 true Keyword 2354 /api/keyword/2354 SKILL true 2354 true Keyword 2843 /api/keyword/2843 FALSE DISCOVERY RATE true 2843 true Keyword 3122 /api/keyword/3122 human true 3122 true Keyword 5937 /api/keyword/5937 human experiment true 5937 true Keyword 6405 /api/keyword/6405 LANGUAGE true 6405 true Keyword 12383 /api/keyword/12383 synthesis true 12383 true Keyword 17164 /api/keyword/17164 biomedicine true 17164 true Keyword 1002221 /api/keyword/1002221 Attention true 1002221 true Keyword 2325366 /api/keyword/2325366 statistical reasoning true true MtaRating 10486385 /api/mtarating/10486385 II. 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Committee on Regional Studies RegTB Institute 14100 /api/institute/14100 Committee on Regional Studies HASSELIX RTB [1901-] 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11185000 /api/sjrrating/11185000 sjr:Q1 (2021) Scopus - Multidisciplinary PLOS ONE 1932-6203 1932-6203 16 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 Scopus - Multidisciplinary true 1000 true Q1 DIRECT true true Reference 21475159 /api/reference/21475159 1. Genovese, CR, Lazar, NA, Nichols, T., Thresholding of statistical maps in functional neuroimaging using the false discovery rate (2002) NeuroImage, 15 (4), pp. 870-878. , https://doi.org/10.1006/nimg.2001.1037, PMID: 11906227 1 false true Reference 21475158 /api/reference/21475158 2. 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(<span class="authorship-author-name">Menyhart Otilia</span> <span class="authorAux-mtmt"> onkologia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10105035"><a href="/gui2/?type=authors&mode=browse&sel=10105035" target="_blank">Weltz B. (<span class="authorship-author-name">Bernhardt-Weltz Boglárka</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy B. ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32082857" target="_blank">Multipletesting.com: A tool for life science researchers for multiple hypothesis testing correction</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">6</span> <span class="page"> Paper 0245824. 12 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0245824" target="_blank" href="https://doi.org/10.1371/journal.pone.0245824"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000664642200006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000664642200006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85107814325" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85107814325"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34106935" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34106935&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 148</span> | Independent citation: 139 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 145 | Number of citations in Scopus:&nbsp;102 | WoS/Scopus assigned:&nbsp;148 | Number of citations with DOI:&nbsp;148 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32082857</span> | <span class="status-data status-APPROVED"> Published </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> Magyar-koreai kutatás-fejlesztési együttműködési pályázat(2018-2.1.17-TÉT-KR-00001) Funder: NKFIH, (2020-1.1.6-JOVO-2021-00013), (2018-1.3.1-VKE-2018-00032), Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2026.04.20. 13:08 Ibolya Katalin Pintér (SE_Bioinformatika_Admin5_PI, admin) </div> </div></div>