{ "labelLang" : "hun", "responseDate" : "2024-03-29 00:48", "content" : { "otype" : "JournalArticle", "mtid" : 3207422, "status" : "VALIDATED", "published" : true, "comment" : "First Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Export Date: 4 February 2020 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Export Date: 20 March 2020 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Export Date: 23 April 2020 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Export Date: 15 July 2020 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Export Date: 16 November 2020 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Cited By :1 \n Export Date: 11 March 2021 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Cited By :1 \n Export Date: 12 April 2021 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; Department of Dietetics and Nutrition Sciences, Vas u. 17, Hungary; email: orbancsaba1988@gmail.com\nFirst Department of Pediatrics, Semmelweis University, Bókay u. 53, Budapest, H-1083, Hungary \n Department of Dietetics and Nutrition Sciences, Faculty of Health Sciences, Semmelweis University, Vas u. 17, Budapest, H-1088, Hungary \n Department of Laboratory Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Bionics Innovation Centre, 1089 Szentkirályi u 8, Budapest, H-1085, Hungary \n MTA-SE, Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, H-1083, Hungary \n Cited By :1 \n Export Date: 19 April 2021 \n CODEN: IMLED \n Correspondence Address: Orbán, C.; 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"label" : "IMMUNOLOGY LETTERS 0165-2478 1879-0542", "pIssn" : "0165-2478", "eIssn" : "1879-0542", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 1921, "snippet" : true }, "volume" : "185", "firstPage" : "48", "lastPage" : "51", "firstPageOrInternalIdForSort" : "48", "pageLength" : 4, "publishedYear" : 2017, "abstractText" : "AIM: Although Crohn's disease (CD) is an extensively investigated autoimmune condition, knowledge on early phase activation of lymphocytes, especially CD8+ Tc cells is scarce. Our aim was to investigate the calcium influx characteristics of CD8+ cells upon activation as well as the expression and function of Kv1.3 and IKCa1 lymphocyte potassium channels. METHODS: We took peripheral blood from 12 healthy controls, 23 CD children on conventional therapy and 6 severe CD children before and after infliximab therapy. Intracellular calcium levels were monitored in CD8+ lymphocytes using flow cytometry. RESULTS: In CD treated with standard therapy calcium response during activation was elevated. This was not affected by the inhibition of Kv1.3 or IKCa1 potassium channels. After the switch to infliximab potassium channel function and expression of CD8+ lymphocytes were comparable to healthy controls in severe CD. CONCLUSION: Calcium handling of CD8+ lymphocytes is altered in pediatric CD, which is normalized by infliximab therapy.", "subjects" : [ { "otype" : "Classification", "mtid" : 12302, "link" : "/api/classification/12302", "label" : "Gasztroenterológia és hepatológia", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12220, "link" : "/api/classification/12220", "label" : "Gyermekorvoslás", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12146, "link" : "/api/classification/12146", "label" : "Immunológia", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2017, "packet" : "297497", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GREEN", "oaTypeDisp" : "GREEN", "oaCheckDate" : "2024-02-18", "oaFree" : true, "oaLink" : "http://real.mtak.hu/64778", "citationCount" : 3, "citationCountUnpublished" : 0, "citationCountWoOther" : 3, "independentCitCountWoOther" : 3, "nationalOriginCitationCount" : 1, "foreignEditionCitationCount" : 3, "doiCitationCount" : 3, "wosCitationCount" : 3, "scopusCitationCount" : 3, "wosScopusCitationCount" : 3, "wosScopusCitationCountWoOther" : 3, "wosScopusIndependentCitationCount" : 3, "wosScopusIndependentCitationCountWoOther" : 3, "independentCitationCount" : 3, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 3, "independentCitingPubCount" : 3, "citingPubCountWoOther" : 3, "independentCitingPubCountWoOther" : 3, "unhandledCitingPubCount" : 0, "citedPubCount" : 6, "citedCount" : 6, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 3 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 2020, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10704454, "link" : "/api/sjrrating/10704454", "label" : "sjr:Q2 (2017) Scopus - 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