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: false, "published" : true, "oldId" : 10037907, "snippet" : true }, "volume" : "10", "issue" : "14", "firstPage" : "4864", "lastPage" : "4873", "firstPageOrInternalIdForSort" : "4864", "pageLength" : 10, "publishedYear" : 2021, "abstractText" : "Background: Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required. This study examines the question of whether TYA T-ALL has a specific biological-molecular profile distinct from pediatric or adult T-ALL. Methods: Genomic characterization was undertaken of a retrospective discovery cohort of 80 patients aged 15-26 years with primary or relapsed T-ALL, using a combination of Genome-Wide Human SNP Array 6.0, targeted gene mutation and promoter methylation analyses. Findings were confirmed by MLPA, real-time quantitative PCR, and FISH. Whole Exome Sequencing was performed in 4 patients with matched presentation and relapse to model clonal evolution. A prevalence analysis was performed on a final data set of 1,792 individual cases to identify genetic lesions with age specific frequency patterns, including 972 pediatric (1-14 years), 439 TYA (15-24 years) and 381 adult (>= 25 years) cases. These cases were extracted from 19 publications with comparable genomic data identified through a PubMed search. Results: Genomic characterization of this large cohort of TYA T-ALL patients identified recurrent isochromosome 7q i(7q) in our discovery cohort (n = 3). Prevalence analysis did not identify any age specific genetic abnormalities. Genomic analysis of 6 pairs of matched presentation - relapsed T-ALL established that all relapses were clonally related to the initial leukemia. Whole exome sequencing analysis revealed recurrent, targetable, mutations disrupting NOTCH, PI3K/AKT/mTOR, FLT3, NRAS as well as drug metabolism pathways. Conclusions: All genetic aberrations in TYA T-ALL occurred with an incidence similar or intermediate to that reported in the pediatric and adult literature, demonstrating that overall TYA T-ALL exhibits a transitional genomic profile. Analysis of matched presentation - relapse supported the hypothesis that relapse is driven by the Darwinian evolution of sub-clones associated with drug resistance (NT5C2 and TP53 mutations) and re-iterative mutation of known key T-ALL drivers, including NOTCH1.", "fundings" : [ { "otype" : "Funding", "mtid" : 2000583, "link" : "/api/funding/2000583", "label" : "Kay Kendall Leukaemia Fund(KKLF417)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 2000584, "link" : "/api/funding/2000584", "label" : "The European Hematology Association— EHA Partner Fellowship(2011/01)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 2000585, "link" : "/api/funding/2000585", "label" : "INCA- Brazil(Lady Tata Memorial Trust— LTMT International Award for Research in Leukaemia and the Ministry of Health)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 2000586, "link" : "/api/funding/2000586", "label" : "(Leukaemia & Lymphoma 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Zhang JH, 2012, NATURE, V481, P157, DOI 10.1038/nature10725", "listPosition" : 1, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305041, "link" : "/api/reference/21305041", "label" : "2. Yuan L, 2015, ANN HEMATOL, V94, P1817, DOI 10.1007/s00277-015-2474-0", "listPosition" : 2, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305040, "link" : "/api/reference/21305040", "label" : "3. Yu L, 2011, LEUKEMIA, V25, P1042, DOI 10.1038/leu.2011.33", "listPosition" : 3, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305039, "link" : "/api/reference/21305039", "label" : "4. Yang YL, 2012, PEDIATR BLOOD CANCER, V58, P846, DOI 10.1002/pbc.24021", "listPosition" : 4, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305038, "link" : "/api/reference/21305038", "label" : "5. Ward AF, 2012, BLOOD, V120, P3397, DOI 10.1182/blood-2012-05-378596", "listPosition" : 5, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305037, "link" : "/api/reference/21305037", "label" : "6. Vicente C, 2015, HAEMATOLOGICA, V100, P1301, DOI 10.3324/haematol.2015.130179", "listPosition" : 6, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305036, "link" : "/api/reference/21305036", "label" : "7. Van Vlierberghe P, 2011, J EXP MED, V208, P2571, DOI 10.1084/jem.20112239", "listPosition" : 7, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305035, "link" : "/api/reference/21305035", "label" : "8. Van Vlierberghe P, 2012, J CLIN INVEST, V122, P3398, DOI 10.1172/JCI61269", "listPosition" : 8, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305034, "link" : "/api/reference/21305034", "label" : "9. Van Vlierberghe P, 2013, BLOOD, V122, P74, DOI 10.1182/blood-2013-03-491092", "listPosition" : 9, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305033, "link" : "/api/reference/21305033", "label" : "10. Van Vlierberghe P, 2008, BLOOD, V111, P4668, DOI 10.1182/blood-2007-09-111872", "listPosition" : 10, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305032, "link" : "/api/reference/21305032", "label" : "11. van Vlierberghe P, 2008, BRIT J HAEMATOL, V143, P153, DOI 10.1111/j.1365-2141.2008.07314.x", "listPosition" : 11, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305031, "link" : "/api/reference/21305031", "label" : "12. Tzoneva G, 2013, NAT MED, V19, P368, DOI 10.1038/nm.3078", "listPosition" : 12, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305030, "link" : "/api/reference/21305030", "label" : "13. Swaminathan S, 2013, NAT MED, V19, P1014, DOI 10.1038/nm.3247", "listPosition" : 13, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305029, "link" : "/api/reference/21305029", "label" : "14. Sulong S, 2009, BLOOD, V113, P100, DOI 10.1182/blood-2008-07-166801", "listPosition" : 14, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305028, "link" : "/api/reference/21305028", "label" : "15. Sinclair PB, 2004, CANCER RES, V64, P4089, DOI 10.1158/0008-5472.CAN-03-1871", "listPosition" : 15, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305027, "link" : "/api/reference/21305027", "label" : "16. Shi Y., 2020, Haematologica, V106, P1056", "listPosition" : 16, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305026, "link" : "/api/reference/21305026", "label" : "17. Serafin V, 2017, BLOOD, V130, P2750, DOI 10.1182/blood-2017-05-784603", "listPosition" : 17, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305025, "link" : "/api/reference/21305025", "label" : "18. Sellar RS, 2018, BRIT J HAEMATOL, V181, P515, DOI 10.1111/bjh.15208", "listPosition" : 18, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305024, "link" : "/api/reference/21305024", "label" : "19. Schmitz R, 2012, NATURE, V490, P116, DOI 10.1038/nature11378", "listPosition" : 19, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305023, "link" : "/api/reference/21305023", "label" : "20. Sandell S, 2013, BRIT J CANCER, V108, P438, DOI 10.1038/bjc.2012.562", "listPosition" : 20, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305022, "link" : "/api/reference/21305022", "label" : "21. Safavi S, 2015, HAEMATOLOGICA, V100, P55, DOI 10.3324/haematol.2014.112912", "listPosition" : 21, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305021, "link" : "/api/reference/21305021", "label" : "22. Piovan E, 2013, CANCER CELL, V24, P766, DOI 10.1016/j.ccr.2013.10.022", "listPosition" : 22, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305020, "link" : "/api/reference/21305020", "label" : "23. Patrick K, 2014, BRIT J HAEMATOL, V166, P421, DOI 10.1111/bjh.12882", "listPosition" : 23, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305019, "link" : "/api/reference/21305019", "label" : "24. Patrick K, 2014, BLOOD, V124, DOI 10.1182/blood.V124.21.3702.3702", "listPosition" : 24, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305018, "link" : "/api/reference/21305018", "label" : "25. Mullighan CG, 2011, NATURE, V471, P235, DOI 10.1038/nature09727", "listPosition" : 25, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305017, "link" : "/api/reference/21305017", "label" : "26. Mullighan CG, 2007, NATURE, V446, P758, DOI 10.1038/nature05690", "listPosition" : 26, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305016, "link" : "/api/reference/21305016", "label" : "27. Mullighan CG, 2008, SCIENCE, V322, P1377, DOI 10.1126/science.1164266", "listPosition" : 27, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305015, "link" : "/api/reference/21305015", "label" : "28. Morin RD, 2016, CLIN CANCER RES, V22, P2290, DOI 10.1158/1078-0432.CCR-15-2123", "listPosition" : 28, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305014, "link" : "/api/reference/21305014", "label" : "29. Meijerink JPP, 2010, BEST PRACT RES CL HA, V23, P307, DOI 10.1016/j.beha.2010.08.002", "listPosition" : 29, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305013, "link" : "/api/reference/21305013", "label" : "30. Martineau M, 1996, GENE CHROMOSOME CANC, V17, P21, DOI 10.1002/(SICI)1098-2264(199609)17:1<21::AID-GCC4>3.0.CO;2-4", "listPosition" : 30, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305012, "link" : "/api/reference/21305012", "label" : "31. Marks DI, 2009, BLOOD, V114, P5136, DOI 10.1182/blood-2009-08-231217", "listPosition" : 31, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305011, "link" : "/api/reference/21305011", "label" : "32. Mansur MB, 2015, BRIT J HAEMATOL, V171, P574, DOI 10.1111/bjh.13613", "listPosition" : 32, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305010, "link" : "/api/reference/21305010", "label" : "33. Mansur MB, 2011, LEUKEMIA, V25, P1368, DOI 10.1038/leu.2011.96", "listPosition" : 33, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305009, "link" : "/api/reference/21305009", "label" : "34. Lopez-Nieva P, 2012, CARCINOGENESIS, V33, P452, DOI 10.1093/carcin/bgr271", "listPosition" : 34, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305008, "link" : "/api/reference/21305008", "label" : "35. Liu Y, 2017, NAT GENET, V49, P1211, DOI 10.1038/ng.3909", "listPosition" : 35, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305007, "link" : "/api/reference/21305007", "label" : "36. Li Y, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002200", "listPosition" : 36, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305006, "link" : "/api/reference/21305006", "label" : "37. Li N, 2014, NAT CELL BIOL, V16, P1080, DOI 10.1038/ncb3046", "listPosition" : 37, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305005, "link" : "/api/reference/21305005", "label" : "38. La Starzaa R, 2013, LEUKEMIA RES, V37, P928, DOI 10.1016/j.leukres.2013.04.005", "listPosition" : 38, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305004, "link" : "/api/reference/21305004", "label" : "39. Kunz JB, 2015, HAEMATOLOGICA, V100, P1442, DOI 10.3324/haematol.2015.129692", "listPosition" : 39, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305003, "link" : "/api/reference/21305003", "label" : "40. Karrman K, 2015, J HEMATOL ONCOL, V8, DOI 10.1186/s13045-015-0138-0", "listPosition" : 40, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305002, "link" : "/api/reference/21305002", "label" : "41. Jonveaux P, 1996, LEUKEMIA, V10, P1453", "listPosition" : 41, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305001, "link" : "/api/reference/21305001", "label" : "42. Jenkinson S, 2013, LEUKEMIA, V27, P41, DOI 10.1038/leu.2012.176", "listPosition" : 42, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21305000, "link" : "/api/reference/21305000", "label" : "43. Jenkinson S, 2016, LEUKEMIA, V30, P39, DOI 10.1038/leu.2015.206", "listPosition" : 43, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304999, "link" : "/api/reference/21304999", "label" : "44. Hough R, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-017052", "listPosition" : 44, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304998, "link" : "/api/reference/21304998", "label" : "45. Haydu JE, 2013, CURR OPIN HEMATOL, V20, P369, DOI 10.1097/MOH.0b013e3283623c61", "listPosition" : 45, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304997, "link" : "/api/reference/21304997", "label" : "46. HAYASHI Y, 1990, BLOOD, V76, P1626", "listPosition" : 46, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304996, "link" : "/api/reference/21304996", "label" : "47. Gutierrez A, 2009, BLOOD, V114, P647, DOI 10.1182/blood-2009-02-206722", "listPosition" : 47, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304995, "link" : "/api/reference/21304995", "label" : "48. Gutierrez A, 2010, BLOOD, V115, P2845, DOI 10.1182/blood-2009-07-234377", "listPosition" : 48, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304994, "link" : "/api/reference/21304994", "label" : "49. Gutierrez A, 2010, J CLIN ONCOL, V28, P3816, DOI 10.1200/JCO.2010.28.3390", "listPosition" : 49, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304993, "link" : "/api/reference/21304993", "label" : "50. Grossmann V, 2013, GENE CHROMOSOME CANC, V52, P410, DOI 10.1002/gcc.22039", "listPosition" : 50, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304992, "link" : "/api/reference/21304992", "label" : "51. Greaves M, 2012, NATURE, V481, P306, DOI 10.1038/nature10762", "listPosition" : 51, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304991, "link" : "/api/reference/21304991", "label" : "52. Furness CL, 2018, LEUKEMIA, V32, P1984, DOI 10.1038/s41375-018-0046-8", "listPosition" : 52, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304990, "link" : "/api/reference/21304990", "label" : "53. Flotho C, 2006, BLOOD, V108, P1050, DOI 10.1182/blood-2006-01-0322", "listPosition" : 53, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304989, "link" : "/api/reference/21304989", "label" : "54. Flex E, 2008, J EXP MED, V205, P751, DOI 10.1084/jem.20072182", "listPosition" : 54, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304988, "link" : "/api/reference/21304988", "label" : "55. De Keersmaecker K, 2013, NAT GENET, V45, P186, DOI 10.1038/ng.2508", "listPosition" : 55, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304987, "link" : "/api/reference/21304987", "label" : "56. Chaar T., 2013, COMBINED HAPLOINSUFF", "listPosition" : 56, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304986, "link" : "/api/reference/21304986", "label" : "57. Case M, 2008, CANCER RES, V68, P6803, DOI 10.1158/0008-5472.CAN-08-0101", "listPosition" : 57, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304985, "link" : "/api/reference/21304985", "label" : "58. Beldjord K, 2014, BLOOD, V123, P3739, DOI 10.1182/blood-2014-01-547695", "listPosition" : 58, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304984, "link" : "/api/reference/21304984", "label" : "59. Bandapalli OR, 2013, HAEMATOLOGICA, V98, P928, DOI 10.3324/haematol.2012.073585", "listPosition" : 59, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21304983, "link" : "/api/reference/21304983", "label" : "60. 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