https://m2.mtmt.hu/ hun 2026-05-31 16:23 JournalArticle 32071079 VALIDATED true 0 false 2026-05-20T22:15:24.125+0000 2024-12-06T17:58:41.333+0000 2021-06-15T12:29:17.238+0000 true 10063867 Fekete János Tibor /api/author/10063867 Author true 10063867 2024-05-21T11:05:40.162+0000 2024-12-06T17:58:41.507+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Menyhárt, Otília Gene expression-based biomarkers designating glioblastomas resistant to multiple treatment strategies true true /api/journal/920 REVIEWED true false 920 false 920 true 0143-3334 1460-2180 Journal FOREIGN 42 6 804 813 804 10 2021 {Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery associated with response to subsequent treatment, including temozolomide (TMZ) and nitrosoureas. Gene expression was collected from multiple independent datasets. Patients were categorized as responders/nonresponders based on their survival status at 16 months postsurgery. For each gene, the expression was compared between responders and nonresponders with a Mann–Whitney U-test and receiver operating characteristic. The package ‘roc’ was used to calculate the area under the curve (AUC). The integrated database comprises 454 GBM patients from 3 independent datasets and 10 103 genes. The highest proportion of responders (68\\\\%) were among patients treated with TMZ combined with nitrosoureas, where FCGR2B upregulation provided the strongest predictive value (AUC = 0.72, P \\\\< 0.001). Elevated expression of CSTA and MRPS17 was associated with a lack of response to multiple treatment strategies. DLL3 upregulation was present in subsequent responders to any treatment combination containing TMZ. Three genes (PLSCR1, MX1 and MDM2) upregulated both in the younger cohort and in patients expressing low MGMT delineate a subset of patients with worse prognosis within a population generally associated with a favorable outcome. The identified transcriptomic changes provide biomarkers of responsiveness, offer avenues for preclinical studies and may enhance future GBM patient stratifications. The described methodology provides a reliable pipeline for the initial testing of potential biomarker candidates for future validation studies.} Funding 2007387 /api/funding/2007387 false true Funding 2007388 /api/funding/2007388 false true Funding 2007389 /api/funding/2007389 false true true true 2021 true true true false true false GOLD 2026-05-21 true https://doi.org/10.1093/carcin/bgab024 25 0 25 24 1 25 24 25 19 25 25 24 24 24 1 0 25 24 25 24 0 2 2 Folyóiratcikk Journal Article 24 25 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 1 1 1 2022 0 9 8 9 8 2023 0 8 8 8 8 2024 0 3 3 3 3 2025 0 4 4 4 4 Q1 false 10063867 false false false 2021-06-22T13:26:03.268+0000 Bioinformatika Tanszék (SE / AOK / I); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 3 27 3 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96610742 /api/authorship/96610742 1 0.333 true false false Author 10045338 /api/author/10045338 Menyhart Otilia true 10045338 true Menyhárt Otília true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96610743 /api/authorship/96610743 2 0.333 false false false Author 10063867 /api/author/10063867 Fekete János Tibor true 10063867 true Fekete János Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96610744 /api/authorship/96610744 3 0.333 false true true Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18582703 /api/publicationidentifier/18582703 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1093/carcin/bgab024 https://doi.org/10.1093/carcin/bgab024 false true PublicationIdentifier 19081246 /api/publicationidentifier/19081246 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000670803600003 https://www.webofscience.com/wos/woscc/full-record/000670803600003 true true PublicationIdentifier 19004002 /api/publicationidentifier/19004002 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85108742148 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85108742148 true true PublicationIdentifier 18947428 /api/publicationidentifier/18947428 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33754151 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33754151&dopt=Abstract false true SjrRating 11225180 /api/sjrrating/11225180 339 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/32071079 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10045338"><a href="/gui2/?type=authors&mode=browse&sel=10045338" target="_blank">Menyhárt Otília (<span class="authorship-author-name">Menyhart Otilia</span> <span class="authorAux-mtmt"> onkologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063867"><a href="/gui2/?type=authors&mode=browse&sel=10063867" target="_blank">Fekete János Tibor (<span class="authorship-author-name">Fekete János Tibor</span> <span class="authorAux-mtmt"> Prediktív biomarkerek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32071079" target="_blank">Gene expression-based biomarkers designating glioblastomas resistant to multiple treatment strategies</a></div> <div> <span class="journal-title">CARCINOGENESIS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0143-3334">0143-3334</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-2180">1460-2180</a>)</span>: <span class="journal-volume">42</span> <span class="journal-issue">6</span> <span class="page"> pp 804-813 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/carcin/bgab024" target="_blank" href="https://doi.org/10.1093/carcin/bgab024"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000670803600003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000670803600003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85108742148" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85108742148"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33754151" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33754151&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 25</span> | Független: 24 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 25 | Scopus jelölt:&nbsp;19 | WoS/Scopus jelölt:&nbsp;25 | DOI jelölt:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32071079&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32071079</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="funder"> Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató: Innovációs és Technológiai Minisztérium, Magyar-koreai kutatás-fejlesztési együttműködési pályázat(2018-2.1.17-TÉT-KR-00001) Támogató: NKFIH, (FIEK_16-1-2016-0005) </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 18:58 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>