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The differences between workers in terms of skills, age, gender and anthropometric measures have a large impact on production system performance. In this study, the workforce differences factors in production system design and modelling were investigated, with the aim of understanding how the differences between workers could influence a production system and how they had been considered in previous studies. The papers selected from the Scopus database were categorised based on whether how human factors are incorporated into manufacturing system optimisation and design approaches is discussed therein or is not. To find relevant papers, two sets of keywords were defined: (1) keywords relating to the differences between workers and (2) keywords relating to the kind of problem under study. Furthermore, the investigated papers helped highlight the strengths and weaknesses of the existing literature and derive a discussion on the possible future research steps. © 2021 The Author(s). 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Asensio-Cuesta, S., Diego-Mas, J.A., Canós-Darós, L., Andrés-Romano, C., A Genetic Algorithm for the Design of Job Rotation Schedules Considering Ergonomic and Competence Criteria (2012) The International Journal of Advanced Manufacturing Technology, 60 (9-12), pp. 1161-1174", "listPosition" : 9, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21281909, "link" : "/api/reference/21281909", "label" : "10. Baines, T., Mason, S., Siebers, P.O., Ladbrook, J., Humans: the Missing Link in Manufacturing Simulation? (2004) Simulation Modelling Practice and Theory, 12 (7-8), pp. 515-526", "listPosition" : 10, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 21281910, "link" : "/api/reference/21281910", "label" : "11. 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