Skin cancer is the most common type of cancer in the USA and worldwide. 1 An early
diagnosis is the key to a successful treatment. Among the skin cancers, the malignant
melanoma ( MM) accounts for 1% of the cases while it is responsible for the majority
of deaths. Basal cell carcinoma (BCC) is the most common form of skin cancer with
a very low mortality rate.(2) Unfortunately, skin cancer recurrence is a common problem
for MM and BCC patients. We propose a post-operative scar screening with non-invasive
autofluorescence (AF) imaging to detect an early growth of any residual tissue from
the cancer removal procedure. The screening images can serve also as a visual evidence
for the post-op patient's observation in dynamics. The results of the study show promising
results comparing various post-op scars with recurrent cancer cases.