https://m2.mtmt.hu/ hun 2026-09-21 12:36 JournalArticle 32062540 VALIDATED true Magyar Honvédség Egészségügyi Központ, Onkológiai Osztály; Semmelweis Egyetem, Hungary Belgyógyászati és Onkológiai Klinika, Budapest, Hungary II. Sz. Patológiai Intézet, Budapest, Hungary Export Date: 25 May 2022 CODEN: MGONA Correspondence Address: József, T.; Semmelweis Egyetem, Üllői út 93, Hungary; email: jtimar@gmail.com Chemicals/CAS: cetuximab, 205923-56-4; epidermal growth factor receptor, 79079-06-4; protein p21, 85306-28-1; Cetuximab; EGFR protein, human; ErbB Receptors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras) 0 false 2026-04-20T08:20:27.484+0000 2022-02-28T12:46:43.737+0000 2021-06-09T06:47:40.235+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-01-17T08:47:26.434+0000 2021-06-09T06:51:08.444+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Uhlyarik, Andrea Az EGFR-protein-expresszió negatív prognosztikus és prediktív marker vad RAS típusú vastagbélrákban [EGFR protein is a negative prognostic and predictive factor in wild-type RAS colorectal cancer] true false /api/journal/1131031 REVIEWED true true 1131031 true 1131031 true 0025-0244 2060-0399 Journal HUNGARIAN 65 2 121 127 121 7 2021 Negative predictive markers of the anti-EGFR antibody therapies are RAS or BRAF mutations, while left sidedness can be considered as a positive predictor. Here we analyzed 97 wild type RAS metastatic colorectal cancers looking for the prognostic and predictive roles of EGFR protein expression. We found that right-sided colorectal cancers are characterized by significantly higher EGFR protein expression as compared to left-sided ones, irrespective of the primary or metastatic tissue analysis. Furthermore, tumors with multiple organ involvement are characterized by significantly higher EGFR protein expression as compared to single organ ones. In the homogenous cetuximab treated cohort (n=90) we have found that lower than the applied EGFR protein expression cut-off was associated with favorable survival. In the multivariate analysis only sidedness proved to be a strong independent predictor, however sidedness is an EGFR-dependent predictor of anti-EGFR therapy. Funding 2010283 /api/funding/2010283 false true Funding 2010284 /api/funding/2010284 false true true true 2021 false false true false true false NONE 2026-04-20 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 Q4 false false false false 2021-06-08T06:51:08.283+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); II. Sz. Patológiai Intézet (SE / AOK / I) 5 29 2 11 0 false Language 10001 /api/language/10001 Magyar Hungarian true 1 true PersonAuthorship 96559735 /api/authorship/96559735 1 0.091 true false false Author 10049763 /api/author/10049763 Uhlyarik Andrea true 10049763 true Uhlyarik Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559736 /api/authorship/96559736 2 0.09090909 false false false Piurkó Violetta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559737 /api/authorship/96559737 3 0.09090909 false false false Pápai Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559738 /api/authorship/96559738 4 0.091 false false false Author 10010460 /api/author/10010460 Rásó Erzsébet true 10010460 true Rásó Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559739 /api/authorship/96559739 5 0.09090909 false false false Lahm Erika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559740 /api/authorship/96559740 6 0.09090909 false false false Kiss Edina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559741 /api/authorship/96559741 7 0.09090909 false false false Sikter Márta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559742 /api/authorship/96559742 8 0.09090909 false false false Vachaja József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559743 /api/authorship/96559743 9 0.09090909 false false false Author 10034960 /api/author/10034960 Vízkeleti Laura true 10034960 true Vízkeleti Laura true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559744 /api/authorship/96559744 10 0.091 false false false Author 10017547 /api/author/10017547 Kenessey István true 10017547 true Kenessey István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96559745 /api/authorship/96559745 11 0.091 false true true Author 10000584 /api/author/10000584 Tímár József true 10000584 true Tímár József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18950075 /api/publicationidentifier/18950075 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85107587798 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85107587798 true true PublicationIdentifier 18908938 /api/publicationidentifier/18908938 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34081760 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34081760&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Classification 12306 /api/classification/12306 true true SjrRating 11227174 /api/sjrrating/11227174 2253 1.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q4 DIRECT true true /api/publication/32062540 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10049763"><a href="/gui2/?type=authors&mode=browse&sel=10049763" target="_blank">Uhlyarik Andrea (<span class="authorship-author-name">Uhlyarik Andrea</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Piurkó Violetta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pápai Zsuzsanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010460"><a href="/gui2/?type=authors&mode=browse&sel=10010460" target="_blank">Rásó Erzsébet (<span class="authorship-author-name">Rásó Erzsébet</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lahm Erika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss Edina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sikter Márta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vachaja József </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034960"><a href="/gui2/?type=authors&mode=browse&sel=10034960" target="_blank">Vízkeleti Laura (<span class="authorship-author-name">Vízkeleti Laura</span> <span class="authorAux-mtmt"> molekuláris biológia, daganat (epi)genomika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017547"><a href="/gui2/?type=authors&mode=browse&sel=10017547" target="_blank">Kenessey István (<span class="authorship-author-name">Kenessey István</span> <span class="authorAux-mtmt"> Patológia, onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000584"><a href="/gui2/?type=authors&mode=browse&sel=10000584" target="_blank">Tímár József ✉ (<span class="authorship-author-name">Tímár József</span> <span class="authorAux-mtmt"> Rákkutatás, daganatpathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32062540" target="_blank">Az EGFR-protein-expresszió negatív prognosztikus és prediktív marker vad RAS típusú vastagbélrákban</a></div> <div> <span class="journal-title">MAGYAR ONKOLÓGIA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0025-0244">0025-0244</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2060-0399">2060-0399</a>)</span>: <span class="journal-volume">65</span> <span class="journal-issue">2</span> <span class="page"> pp 121-127 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Magyar | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85107587798" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85107587798"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34081760" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34081760&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q4</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q4</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32062540&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32062540</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (NKFIH K-116151), (NVKP_16-1-2016-0004) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2022.02.28. 13:46 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Magyar Honvédség Egészségügyi Központ, Onkológiai Osztály; Semmelweis Egyetem, Hungary Belgyógyászati és Onkológiai Klinika, Budapest, Hungary II. Sz. Patológiai Intézet, Budapest, Hungary Export Date: 25 May 2022 CODEN: MGONA Correspondence Address: József, T.; Semmelweis Egy...</pre> </div></div>