https://m2.mtmt.hu/ eng 2026-10-25 11:54 JournalArticle 3205520 APPROVED true Intensive Care Unit, University of Medicine and Pharmacy, Tirgu Mures, Romania Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony str. 43, Budapest, 1083, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :18 Export Date: 9 March 2021 CODEN: BRBUD Correspondence Address: Borbély, Z.; Department of Pharmacology, Szigony str. 43, Hungary; email: zoltan@drborbely.hu Chemicals/CAS: bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3; dopamine, 51-61-6, 62-31-7; fampridine, 1003-40-3, 504-24-5; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noradrenalin, 1407-84-7, 51-41-2; tetrodotoxin, 4368-28-9, 4664-41-9; egtazic acid, 67-42-5; tritium, 10028-17-8; 4-Aminopyridine; Analgesics; Anesthetics, Local; Calcium Chelating Agents; Catecholamines; Egtazic Acid; Potassium Channel Blockers; Tritium Manufacturers: Tocris Cookson, United Kingdom Intensive Care Unit, University of Medicine and Pharmacy, Tirgu Mures, Romania Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony str. 43, Budapest, 1083, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :18 Export Date: 20 March 2021 CODEN: BRBUD Correspondence Address: Borbély, Z.; Department of Pharmacology, Szigony str. 43, Hungary; email: zoltan@drborbely.hu Chemicals/CAS: bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3; dopamine, 51-61-6, 62-31-7; fampridine, 1003-40-3, 504-24-5; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noradrenalin, 1407-84-7, 51-41-2; tetrodotoxin, 4368-28-9, 4664-41-9; egtazic acid, 67-42-5; tritium, 10028-17-8; 4-Aminopyridine; Analgesics; Anesthetics, Local; Calcium Chelating Agents; Catecholamines; Egtazic Acid; Potassium Channel Blockers; Tritium Manufacturers: Tocris Cookson, United Kingdom Intensive Care Unit, University of Medicine and Pharmacy, Tirgu Mures, Romania Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony str. 43, Budapest, 1083, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :18 Export Date: 7 September 2021 CODEN: BRBUD Correspondence Address: Borbély, Z.; Department of Pharmacology, Szigony str. 43, Hungary; email: zoltan@drborbely.hu Chemicals/CAS: bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3; dopamine, 51-61-6, 62-31-7; fampridine, 1003-40-3, 504-24-5; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noradrenalin, 1407-84-7, 51-41-2; tetrodotoxin, 4368-28-9, 4664-41-9; egtazic acid, 67-42-5; tritium, 10028-17-8; 4-Aminopyridine; Analgesics; Anesthetics, Local; Calcium Chelating Agents; Catecholamines; Egtazic Acid; Potassium Channel Blockers; Tritium Manufacturers: Tocris Cookson, United Kingdom 0 2017-06-19T12:03:47.000+0000 false 3205520 2026-10-18T03:54:50.149+0000 2021-03-31T07:09:12.971+0000 2017-03-28T11:40:05.000+0000 true 91 Baranyi Mária /api/author/91 Author Mária Baranyi (Molekuláris farmakológia) true 91 2026-01-12T09:29:42.867+0000 2026-01-12T09:29:42.867+0000 2020-12-17T13:46:00.826+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Sircuta, C true true /api/journal/796 REVIEWED BRAIN RESEARCH BULLETIN 0361-9230 1873-2747 true false 796 false 796 true 0361-9230 1873-2747 Journal FOREIGN 124 21 26 21 6 2016 Because local anesthetics are known to inhibit both sodium and potassium channels, and anesthetic properties have been attributed to the former effect, we compared their effects with those of tetrodotoxin (TTX), a selective Na(+) channel inhibitor with anesthetic activity, and 4-aminopyridine (4-AP), a selective potassium channel blocker with convulsive activity, on transmitter release during rest and in response to field (axonal) stimulation using the microvolume perfusion method and isolated prefrontal cortex and spinal cord slice preparations loaded with the radioactive transmitters [(3)H]dopamine ([(3)H]DA) and [(3)H]noradrenaline ([(3)H]NA). It is also known that local anesthetics may exert analgesic effect and, rarely, some adverse effects on the central nervous system (CNS). Neurochemical evidence demonstrated that local anesthetics administered at concentrations ranging from 0.5 to 5mM, which might have been intentionally or accidentally achieved in clinical practice (e.g., during spinal and epidural anesthesia or peripheral nerve block), led to presynaptic failures during neurochemical transmission, including inhibited transmitter release associated with axonal firing and markedly enhanced extraneuronal concentrations of transmitters due to increased resting, [Ca(2+)]o-independent release. Tetrodotoxin, a toxin with selective Na(+) channel-blocking properties, inhibited the stimulation-evoked release but failed to affect the resting release. In contrast, the potassium channel inhibitor 4-AP enhanced both the resting- and action potential-evoked transmitter releases. It is concluded that effects of local anesthetics on resting catecholamine release in the spinal cord may contribute to their action during neuropathic pain relief and spinal analgesia as well as to their side effects in the CNS. true true 2017 782593 true true true false true false NONE 2026-10-18 false true 10060326 Borbély Zoltán /api/author/10060326 Author Zoltán Borbély (orálbiológia) true 10060326 23 0 23 20 7 23 23 23 21 23 23 20 20 20 3 0 23 20 23 20 0 9 9 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 4 4 4 4 2017 0 5 3 5 3 2018 0 2 2 2 2 2019 0 5 5 5 5 2020 0 2 1 2 1 2021 0 2 2 2 2 2022 0 2 2 2 2 2023 0 0 0 0 0 2024 0 1 1 1 1 Q2 false false false false 2017-06-26T11:41:33.000+0000 2017-03-28T11:41:33.000+0000 Farmakológiai Kutatócsoport (KOKI / GYO); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); MTA Kísérleti Orvostudományi Kutatóintézet; Molekuláris Farmakológia Kutatócsoport (KOKI / GYO) 3 17 4 6 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 8948796 /api/authorship/8948796 Sircuta, C 1 0.16666667 true false Sircuta C true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762674 true PersonAuthorship 8948797 /api/authorship/8948797 Lazar, A 2 0.16666667 false false Lazar A true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762673 true PersonAuthorship 8948798 /api/authorship/8948798 Azamfirei, L 3 0.16666667 false false Azamfirei L true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762672 true PersonAuthorship 8948799 /api/authorship/8948799 Baranyi, M [Baranyi, Mária (Molekuláris farma...), author] MTA Kísérleti Orvostudományi Kutatóintézet; Laboratory of Molecular Pharmacology (IEM / DP) 4 0.167 false false Author 91 /api/author/91 Mária Baranyi (Molekuláris farmakológia) Baranyi Mária true 91 true Baranyi M true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762671 true PersonAuthorship 8948800 /api/authorship/8948800 Vizi, ES [Vizi, E. Szilveszter (Neurofarmakológia...), author] Laboratory of Drug Research (IEM / DP); Department of Pharmacology and Pharmacotherapy (SU / FM / I) 5 0.167 false false Author 10000023 /api/author/10000023 E. Szilveszter Vizi (Neurofarmakológia, neurokémia) Vizi E. Szilveszter true 10000023 true Vizi ES true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762670 true PersonAuthorship 8948801 /api/authorship/8948801 Borbely, Z ✉ [Borbély, Zoltán (orálbiológia), author] 6 0.167 false true true Author 10060326 /api/author/10060326 Zoltán Borbély (orálbiológia) Borbély Zoltán true 10060326 true Borbely Z true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 25762669 true PublicationIdentifier 1187541 /api/publicationidentifier/1187541 DOI: 10.1016/j.brainresbull.2016.03.009 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.brainresbull.2016.03.009 https://doi.org/10.1016/j.brainresbull.2016.03.009 false 1567636 true PublicationIdentifier 1187539 /api/publicationidentifier/1187539 WoS: 000380595800003 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000380595800003 https://www.webofscience.com/wos/woscc/full-record/000380595800003 false 1604150 true PublicationIdentifier 1187540 /api/publicationidentifier/1187540 Scopus: 84962074720 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84962074720 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84962074720 false 1604149 true PublicationIdentifier 1187542 /api/publicationidentifier/1187542 PubMed: 26996722 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 26996722 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26996722&dopt=Abstract false 1567637 true SjrRating 10951998 /api/sjrrating/10951998 sjr:Q2 (2016) Scopus - Neuroscience (miscellaneous) BRAIN RESEARCH BULLETIN 0361-9230 1873-2747 55 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 Scopus - Neuroscience (miscellaneous) true 2801 true Q2 DIRECT true true /api/publication/3205520 Sircuta C et al. Correlation between the increased release of catecholamines evoked by local anesthetics and their analgesic and adverse effects: Role of K(+) channel inhibition.. (2016) BRAIN RESEARCH BULLETIN 0361-9230 1873-2747 124 21-26<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Sircuta C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lazar A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Azamfirei L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="91"><a href="/gui2/?type=authors&mode=browse&sel=91" target="_blank">Baranyi M (<span class="authorship-author-name">Baranyi Mária</span> <span class="authorAux-mtmt"> Molekuláris farmakológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000023"><a href="/gui2/?type=authors&mode=browse&sel=10000023" target="_blank">Vizi ES (<span class="authorship-author-name">Vizi E. Szilveszter</span> <span class="authorAux-mtmt"> Neurofarmakológia, neurokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060326"><a href="/gui2/?type=authors&mode=browse&sel=10060326" target="_blank">Borbely Z ✉ (<span class="authorship-author-name">Borbély Zoltán</span> <span class="authorAux-mtmt"> orálbiológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3205520" target="_blank">Correlation between the increased release of catecholamines evoked by local anesthetics and their analgesic and adverse effects: Role of K(+) channel inhibition.</a></div> <div> <span class="journal-title">BRAIN RESEARCH BULLETIN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0361-9230">0361-9230</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-2747">1873-2747</a>)</span>: <span class="journal-volume">124</span> <span class="page"> pp 21-26 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.brainresbull.2016.03.009" target="_blank" href="https://doi.org/10.1016/j.brainresbull.2016.03.009"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000380595800003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000380595800003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84962074720" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84962074720"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="26996722" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26996722&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 23</span> | Independent citation: 20 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 23 | Number of citations in Scopus:&nbsp;21 | WoS/Scopus assigned:&nbsp;23 | Number of citations with DOI:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3205520&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3205520</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 3205520</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2021.03.31. 09:09 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Intensive Care Unit, University of Medicine and Pharmacy, Tirgu Mures, Romania Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony str. 43, Budapest, 1083, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :18 ...</pre> </div></div>