https://m2.mtmt.hu/ eng 2026-09-22 22:31 JournalArticle 32054633 APPROVED true 0 false 2026-09-03T09:12:54.387+0000 2026-05-19T08:10:41.502+0000 2021-06-03T16:00:54.398+0000 true 10030581 Kovács Ervin /api/author/10030581 Author true 10030581 2026-02-20T11:07:12.709+0000 2026-02-20T11:07:12.709+0000 Admin 10013962 /api/admin/10013962 Vasvari Lilian true 10013962 true 2025-02-15T15:12:19.731+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chiovini, Balázs Theoretical Design, Synthesis, and In Vitro Neurobiological Applications of a Highly Efficient Two-Photon Caged GABA Validated on an Epileptic Case true true /api/journal/10068075 REVIEWED true false 10068075 false 10068075 true 2470-1343 2470-1343 Journal FOREIGN 6 23 15029 15045 15029 17 2021 In this paper, we present an additional, new cage-GABA compound, called 4-amino-1-(4′-dimethylaminoisopropoxy-5′,7′-dinitro-2′,3′-dihydro-indol-1-yl)-1-oxobutane-γ-aminobutyric acid (iDMPO-DNI-GABA), and currently, this compound is the only photoreagent, which can be applied for GABA uncaging without experimental compromises. By a systematic theoretical design and successful synthesis of several compounds, the best reagent exhibits a high two-photon efficiency within the 700–760 nm range with excellent pharmacological behavior, which proved to be suitable for a complex epileptic study. Quantum chemical design showed that the optimal length of the cationic side chain enhances the two-photon absorption by 1 order of magnitude due to the cooperating internal hydrogen bonding to the extra nitro group on the core. This feature increased solubility while suppressing membrane permeability. The efficiency was demonstrated in a systematic, wide range of in vitro single-cell neurophysiological experiments by electrophysiological as well as calcium imaging techniques. Scalable inhibitory ion currents were elicited by iDMPO-DNI-GABA with appropriate spatial–temporal precision, blocking both spontaneous and evoked cell activity with excellent efficiency. Additionally, to demonstrate its applicability in a real neurobiological study, we could smoothly and selectively modulate neuronal activities during artificial epileptic rhythms first time in a neural network of GCaMP6f transgenic mouse brain slices. true true 2021 true true true false true false GOLD 2026-09-03 true https://doi.org/10.1021/acsomega.1c01164 16 0 16 7 12 16 16 15 16 16 16 7 7 7 9 0 16 7 16 7 0 10 10 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 2 1 2 1 2022 0 3 1 3 1 2023 0 3 1 3 1 2024 0 4 1 4 1 2025 0 3 2 3 2 2026 0 1 1 1 1 Q1 false false false false 2021-09-13T08:28:50.327+0000 Akadémikus bibliográfia; Anyag- és Környezetkémiai Intézet (TTK); Femtonics Kutató és Fejlesztő Korlátolt Felelős...; Információs Technológiai és Bionikai Kar (PPKE); Kémiai Intézet (ME / AVK); Kísérleti Orvostudományi Kutatóintézet; Neuronhálózat és Dendritikus Aktivitás Kutatócs... (HRN KOKI); Polimer Kémiai Kutatócsoport (HRN TTK / AKI); Richter Gedeon Nyrt.; Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 16 67 10 19 0 true 10013962 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96516105 /api/authorship/96516105 1 0.053 true false true Author 10017949 /api/author/10017949 Chiovini Balázs true 10017949 true Chiovini Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516106 /api/authorship/96516106 2 0.053 true false false Author 10034709 /api/author/10034709 Pálfi Dénes true 10034709 true Pálfi Dénes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516107 /api/authorship/96516107 3 0.05263158 false false false Majoros Myrtill true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516108 /api/authorship/96516108 4 0.053 false false false Author 10053419 /api/author/10053419 Juhász Gábor true 10053419 true Juhász Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516109 /api/authorship/96516109 5 0.053 false false false Author 10054116 /api/author/10054116 Szalay Gergely true 10054116 true Szalay Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516110 /api/authorship/96516110 6 0.053 false false false Author 191 /api/author/191 Katona Gergely true 191 true Katona Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516111 /api/authorship/96516111 7 0.053 false false false Author 10026087 /api/author/10026087 Szőri Milán true 10026087 true Szőri Milán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516112 /api/authorship/96516112 8 0.05263158 false false false Frigyesi Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516113 /api/authorship/96516113 9 0.05263158 false false false Lukácsné Haveland Csilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516114 /api/authorship/96516114 10 0.053 false false false Author 10009842 /api/author/10009842 Szabó Gábor true 10009842 true Szabó Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516115 /api/authorship/96516115 11 0.053 false false false Author 129 /api/author/129 Erdélyi Ferenc true 129 true Erdélyi Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516116 /api/authorship/96516116 12 0.053 false false false Author 198 /api/author/198 Máté Zoltán true 198 true Máté Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516117 /api/authorship/96516117 13 0.053 false false false Author 10049964 /api/author/10049964 Szadai Zoltán true 10049964 true Szadai Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516118 /api/authorship/96516118 14 0.053 false false false Author 10051355 /api/author/10051355 Madarász Miklós true 10051355 true Madarász Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516119 /api/authorship/96516119 15 0.05263158 false false false Author 10089854 /api/author/10089854 Dékány Miklós true true Dékány Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516120 /api/authorship/96516120 16 0.053 false false false Author 10011269 /api/author/10011269 Csizmadia Imre Gyula true 10011269 true Csizmadia Imre G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516121 /api/authorship/96516121 17 0.053 false false true Author 10030581 /api/author/10030581 Kovács Ervin true 10030581 true Kovács Ervin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516122 /api/authorship/96516122 18 0.053 false false true Author 10012926 /api/author/10012926 Rózsa J. Balázs true 10012926 true Rózsa Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96516123 /api/authorship/96516123 19 0.053 false true true Author 10042935 /api/author/10042935 Mucsi Zoltán true 10042935 true Mucsi Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true Institute 19040 /api/institute/19040 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 18888418 /api/publicationidentifier/18888418 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1021/acsomega.1c01164 https://doi.org/10.1021/acsomega.1c01164 false true PublicationIdentifier 19146216 /api/publicationidentifier/19146216 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000663935000030 https://www.webofscience.com/wos/woscc/full-record/000663935000030 false true PublicationIdentifier 19146215 /api/publicationidentifier/19146215 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85108565644 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85108565644 false true PublicationIdentifier 25764662 /api/publicationidentifier/25764662 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34151084 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34151084&dopt=Abstract true true SjrRating 11202005 /api/sjrrating/11202005 72 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 true 1501 true Q1 DIRECT true true /api/publication/32054633 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017949"><a href="/gui2/?type=authors&mode=browse&sel=10017949" target="_blank">Chiovini Balázs ✉ (<span class="authorship-author-name">Chiovini Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034709"><a href="/gui2/?type=authors&mode=browse&sel=10034709" target="_blank">Pálfi Dénes<sup>*</sup> (<span class="authorship-author-name">Pálfi Dénes</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Majoros Myrtill </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053419"><a href="/gui2/?type=authors&mode=browse&sel=10053419" target="_blank">Juhász Gábor (<span class="authorship-author-name">Juhász Gábor</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054116"><a href="/gui2/?type=authors&mode=browse&sel=10054116" target="_blank">Szalay Gergely (<span class="authorship-author-name">Szalay Gergely</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="191"><a href="/gui2/?type=authors&mode=browse&sel=191" target="_blank">Katona Gergely (<span class="authorship-author-name">Katona Gergely</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026087"><a href="/gui2/?type=authors&mode=browse&sel=10026087" target="_blank">Szőri Milán (<span class="authorship-author-name">Szőri Milán</span> <span class="authorAux-mtmt"> Anyagtudomány, Számítógépes kémia</span>) </a> </span> <span class="author-affil"><span title="University of Miskolc">UM</span>/<span title="Faculty of Materials and Metallurgical Engineering">FMME</span>/Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Frigyesi Orsolya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukácsné Haveland Csilla </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009842"><a href="/gui2/?type=authors&mode=browse&sel=10009842" target="_blank">Szabó Gábor (<span class="authorship-author-name">Szabó Gábor</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> <span class="author-affil">Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="129"><a href="/gui2/?type=authors&mode=browse&sel=129" target="_blank">Erdélyi Ferenc (<span class="authorship-author-name">Erdélyi Ferenc</span> <span class="authorAux-mtmt"> Molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil">Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="198"><a href="/gui2/?type=authors&mode=browse&sel=198" target="_blank">Máté Zoltán (<span class="authorship-author-name">Máté Zoltán</span> <span class="authorAux-mtmt"> Molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil">Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049964"><a href="/gui2/?type=authors&mode=browse&sel=10049964" target="_blank">Szadai Zoltán (<span class="authorship-author-name">Szadai Zoltán</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051355"><a href="/gui2/?type=authors&mode=browse&sel=10051355" target="_blank">Madarász Miklós (<span class="authorship-author-name">Madarász Miklós</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089854"><a href="/gui2/?type=authors&mode=browse&sel=10089854" target="_blank">Dékány Miklós (<span class="authorship-author-name">Dékány Miklós</span> <span class="authorAux-mtmt"> analitikai kémia</span>) </a> </span> <span class="author-affil">Gedeon Richter Plc</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011269"><a href="/gui2/?type=authors&mode=browse&sel=10011269" target="_blank">Csizmadia Imre G. (<span class="authorship-author-name">Csizmadia Imre Gyula</span> <span class="authorAux-mtmt"> elméleti szerves kémia, természetes vegyületek ...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030581"><a href="/gui2/?type=authors&mode=browse&sel=10030581" target="_blank">Kovács Ervin ✉ (<span class="authorship-author-name">Kovács Ervin</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Materials and Environmental Chemistry; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Materials and Environmental Chemistry">IMEC</span>/Polymer Chemistry; Femtonics Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rózsa Balázs ✉ (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042935"><a href="/gui2/?type=authors&mode=browse&sel=10042935" target="_blank">Mucsi Zoltán ✉ (<span class="authorship-author-name">Mucsi Zoltán</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="University of Miskolc">UM</span>/<span title="Faculty of Materials and Metallurgical Engineering">FMME</span>/Kémiai Intézet; Femtonics Ltd.</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32054633" target="_blank">Theoretical Design, Synthesis, and In Vitro Neurobiological Applications of a Highly Efficient Two-Photon Caged GABA Validated on an Epileptic Case</a></div> <div> <span class="journal-title">ACS OMEGA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2470-1343">2470-1343</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2470-1343">2470-1343</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">23</span> <span class="page"> pp 15029-15045 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1021/acsomega.1c01164" target="_blank" href="https://doi.org/10.1021/acsomega.1c01164"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000663935000030" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000663935000030"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85108565644" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85108565644"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34151084" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34151084&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 16</span> | Independent citation: 7 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 15 | Number of citations in Scopus:&nbsp;16 | WoS/Scopus assigned:&nbsp;16 | Number of citations with DOI:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32054633&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32054633</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="special-affiliations"> Special affiliation: Bibliografy of Hungarian of Academy of Sciences' academicians </div> <div class="lastModified">Last Modified: 2026.05.19. 10:10 Fruzsina Háromszéki-Virág (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2025.02.15. 16:12 Lilian Vasvari (MTMT Központ, admin) </div> </div></div>