https://m2.mtmt.hu/ hun 2026-09-22 11:36 JournalArticle 32051117 VALIDATED true 11st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary Department of Biomedical Informatics, Center for Preventive Medicine and Digital Health, Mannheim, Germany Department of Neuroradiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany Department of Orthopedics, Semmelweis University, Budapest, Hungary Department of Anatomic Pathology and Experimental Pathology, University Ziekenhuis, Brussels, Belgium Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy Cited By :3 Export Date: 3 February 2023 CODEN: POREF Correspondence Address: Krenacs, T.; 11st Department of Pathology and Experimental Cancer Research, Hungary; email: krenacst@gmail.com 0 false 2026-08-28T13:28:49.090+0000 2022-07-22T10:17:34.673+0000 2021-06-02T09:34:25.155+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-08-19T06:57:09.450+0000 2022-07-22T10:17:34.897+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Maros, Mate E. Cell Cycle Regulatory Protein Expression in Multinucleated Giant Cells of Giant Cell Tumor of Bone: do They Proliferate? true true /api/journal/1035680 REVIEWED true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 27 643146 643146 11 2021 Cells of the monocyte macrophage lineage form multinucleated giant cells (GCs) by fusion, which may express some cell cycle markers. By using a comprehensive marker set, here we looked for potential replication activities in GCs, and investigated whether these have diagnostic or clinical relevance in giant cell tumor of bone (GCTB). GC rich regions of 10 primary and 10 first recurrence GCTB cases were tested using immunohistochemistry in tissue microarrays. The nuclear positivity rate of the general proliferation marker, replication licensing, G1/S-phase, S/G2/M-phase, mitosis promoter, and cyclin dependent kinase (CDK) inhibitor reactions was analyzed in GCs. Concerning Ki67, moderate SP6 reaction was seen in many GC nuclei, while B56 and Mib1 positivity was rare, but the latter could be linked to more aggressive (p = 0.012) phenotype. Regular MCM6 reaction, as opposed to uncommon MCM2, suggested an initial DNA unwinding. Early replication course in GCs was also supported by widely detecting CDK4 and cyclin E, for the first time, and confirming cyclin D1 upregulation. However, post-G1-phase markers CDK2, cyclin A, geminin, topoisomerase-2a, aurora kinase A, and phospho-histone H3 were rare or missing. These were likely silenced by upregulated CDK inhibitors p15(INK4b), p16(INK4a), p27(KIP1), p53 through its effector p21(WAF1) and possibly cyclin G1, consistent with the prevention of DNA replication. In conclusion, the upregulation of known and several novel cell cycle progression markers detected here clearly verify early replication activities in GCs, which are controlled by cell cycle arresting CDK inhibitors at G1 phase, and support the functional maturation of GCs in GCTB. 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class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10080571"><a href="/gui2/?type=authors&mode=browse&sel=10080571" target="_blank">Maros Mate E. (<span class="authorship-author-name">Maros Máté Előd</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032338"><a href="/gui2/?type=authors&mode=browse&sel=10032338" target="_blank">Balla Peter (<span class="authorship-author-name">Balla Péter</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025105"><a href="/gui2/?type=authors&mode=browse&sel=10025105" target="_blank">Micsik Tamas (<span class="authorship-author-name">Micsik Tamás</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004659"><a href="/gui2/?type=authors&mode=browse&sel=10004659" target="_blank">Sapi Zoltan (<span class="authorship-author-name">Sápi Zoltán</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004796"><a href="/gui2/?type=authors&mode=browse&sel=10004796" target="_blank">Szendroi Miklos (<span class="authorship-author-name">Szendrői Miklós</span> <span class="authorAux-mtmt"> Ortopédia: felnőtt ortopédia, csont- és lágyrés...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Ortopédiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wenz Holger </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Groden Christoph </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Forsyth Ramses G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Picci Piero </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007878"><a href="/gui2/?type=authors&mode=browse&sel=10007878" target="_blank">Krenacs Tibor ✉ (<span class="authorship-author-name">Krenács Tibor</span> <span class="authorAux-mtmt"> Sejtbiológia, immunológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32051117" target="_blank">Cell Cycle Regulatory Protein Expression in Multinucleated Giant Cells of Giant Cell Tumor of Bone: do They Proliferate?</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">27</span> <span class="page"> Paper 643146. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/pore.2021.643146" target="_blank" href="https://doi.org/10.3389/pore.2021.643146"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000650985100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000650985100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105985896" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105985896"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34257609" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257609&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 5 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32051117&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32051117</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (LSHC-CT- 2006-018814) </div> <div class="lastModified">Utolsó módosítás: 2022.07.22. 12:17 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: 11st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary Department of Biomedical Informatics, Center for Preventive Medicine and Digital Health, Mannheim, Germany Department of Neuroradiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany Department of ...</pre> </div></div>