Association Between Age at Diabetes Onset and Subsequent Risk of Dementia

https://m2.mtmt.hu/ hun 2026-05-31 13:12 JournalArticle 32050988 VALIDATED true Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Inserm U1153, Paris, France Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France Department of Epidemiology and Public Health, University College London, United Kingdom Department of Internal Medicine and Oncology, Semmelweis University Faculty of Medicine, Budapest, Hungary Department of Public Health, Semmelweis University Faculty of Medicine, Budapest, Hungary Cardiovascular Research Institute Maastricht (CARIM), Department of Medicine, Maastricht University Medical Centre, Maastricht, Netherlands Cited By :8 Export Date: 19 November 2021 CODEN: JAMAA Correspondence Address: Singh-Manoux, A.; EpiAgeing, 10 Avenue de Verdun, France; email: archana.singh-manoux@inserm.fr Chemicals/CAS: glucose, 50-99-7, 84778-64-3 0 false 2026-05-21T10:04:54.398+0000 2021-06-02T09:07:59.762+0000 2021-06-02T09:05:42.174+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2022-11-25T20:14:38.772+0000 2021-06-02T09:07:59.780+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Amidei, Claudio Barbiellini Association Between Age at Diabetes Onset and Subsequent Risk of Dementia true true /api/journal/2954 REVIEWED JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 0098-7484 1538-3598 true false 2954 false 2954 true 0098-7484 1538-3598 Journal FOREIGN 325 16 1640 1649 1640 10 2021 Key PointsQuestionWhat is the association between age at onset of type 2 diabetes and subsequent risk of dementia? FindingsIn this prospective cohort study of 10095 participants, younger age at onset of type 2 diabetes was significantly associated with higher risk for incident dementia; at age 70, the hazard ratio for every 5-year earlier age at type 2 diabetes onset was 1.24. MeaningYounger age at diabetes onset was associated with higher risk of subsequent dementia. ImportanceTrends in type 2 diabetes show an increase in prevalence along with younger age of onset. While vascular complications of early-onset type 2 diabetes are known, the associations with dementia remains unclear. ObjectiveTo determine whether younger age at diabetes onset is more strongly associated with incidence of dementia. Design, Setting, and ParticipantsPopulation-based study in the UK, the Whitehall II prospective cohort study, established in 1985-1988, with clinical examinations in 1991-1993, 1997-1999, 2002-2004, 2007-2009, 2012-2013, and 2015-2016, and linkage to electronic health records until March 2019. The date of final follow-up was March 31, 2019. ExposuresType 2 diabetes, defined as a fasting blood glucose level greater than or equal to 126 mg/dL at clinical examination, physician-diagnosed type 2 diabetes, use of diabetes medication, or hospital record of diabetes between 1985 and 2019. Main Outcomes and MeasuresIncident dementia ascertained through linkage to electronic health records. ResultsAmong 10095 participants (67.3% men; aged 35-55 years in 1985-1988), a total of 1710 cases of diabetes and 639 cases of dementia were recorded over a median follow-up of 31.7 years. Dementia rates per 1000 person-years were 8.9 in participants without diabetes at age 70 years, and rates were 10.0 per 1000 person-years for participants with diabetes onset up to 5 years earlier, 13.0 for 6 to 10 years earlier, and 18.3 for more than 10 years earlier. In multivariable-adjusted analyses, compared with participants without diabetes at age 70, the hazard ratio (HR) of dementia in participants with diabetes onset more than 10 years earlier was 2.12 (95% CI, 1.50-3.00), 1.49 (95% CI, 0.95-2.32) for diabetes onset 6 to 10 years earlier, and 1.11 (95% CI, 0.70-1.76) for diabetes onset 5 years earlier or less; linear trend test (P<.001) indicated a graded association between age at onset of type 2 diabetes and dementia. At age 70, every 5-year younger age at onset of type 2 diabetes was significantly associated with an HR of dementia of 1.24 (95% CI, 1.06-1.46) in analyses adjusted for sociodemographic factors, health behaviors, and health-related measures. Conclusions and RelevanceIn this longitudinal cohort study with a median follow-up of 31.7 years, younger age at onset of diabetes was significantly associated with higher risk of subsequent dementia. This cohort study uses UK Whitehall cohort data to examine the association between age at type 2 diabetes onset and incident dementia. true true 2021 true true true false true false PAY 2026-05-21 false 277 1 277 269 4 274 275 254 268 277 277 269 269 269 8 0 277 269 277 269 0 3 3 Folyóiratcikk Journal Article 24 271 Könyvrészlet Chapter in Book 25 4 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 1 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 9 8 9 8 2022 0 36 34 36 34 2023 0 65 65 65 65 2024 0 69 65 69 65 2025 0 73 73 73 73 2026 0 25 24 25 24 D1 false 10024030 false false false 2021-06-01T09:07:59.547+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Népegészségtani Intézet (SE / AOK / I) 1 11 2 10 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 96496674 /api/authorship/96496674 Amidei, Claudio Barbiellini 1 0.1 true false false Amidei Claudio Barbiellini true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496675 /api/authorship/96496675 Fayosse, Aurore 2 0.1 false false false Fayosse Aurore true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496676 /api/authorship/96496676 Dumurgier, Julien 3 0.1 false false false Dumurgier Julien true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496677 /api/authorship/96496677 Machado-Fragua, Marcos D. 4 0.1 false false false Machado-Fragua Marcos D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496678 /api/authorship/96496678 Tabak, Adam G. [Tabák, Ádám (belgyógyászat, di...), szerző] Népegészségtani Intézet (SE / AOK / I); Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 5 0.1 false false false Author 10024030 /api/author/10024030 Tabák Ádám (belgyógyászat, diabetológia) Tabák Ádám true 10024030 true Tabak Adam G. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496679 /api/authorship/96496679 van, Sloten Thomas 6 0.1 false false false van Sloten Thomas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496680 /api/authorship/96496680 Kivimaki, Mika 7 0.1 false false false Kivimaki Mika true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496681 /api/authorship/96496681 Dugravot, Aline 8 0.1 false false false Dugravot Aline true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496682 /api/authorship/96496682 Sabia, Severine 9 0.1 false false false Sabia Severine true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96496683 /api/authorship/96496683 Singh-Manoux, Archana ✉ 10 0.1 false true true Singh-Manoux Archana true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18877695 /api/publicationidentifier/18877695 DOI: 10.1001/jama.2021.4001 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.1001/jama.2021.4001 https://doi.org/10.1001/jama.2021.4001 false true PublicationIdentifier 18877696 /api/publicationidentifier/18877696 WoS: 000645617800021 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000645617800021 https://www.webofscience.com/wos/woscc/full-record/000645617800021 false true PublicationIdentifier 18877698 /api/publicationidentifier/18877698 Scopus: 85105040432 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85105040432 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105040432 false true PublicationIdentifier 18877697 /api/publicationidentifier/18877697 PubMed: 33904867 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33904867 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33904867&dopt=Abstract false true Classification 12215 /api/classification/12215 Klinikai orvostan true true Classification 12124 /api/classification/12124 Orvos- és egészségtudomány true true Keyword 183 /api/keyword/183 SAFETY true 183 true Keyword 2387 /api/keyword/2387 PERFORMANCE true 2387 true Keyword 3736 /api/keyword/3736 QUALITY true 3736 true Keyword 11659 /api/keyword/11659 IMPROVEMENT true 11659 true Keyword 2319024 /api/keyword/2319024 CESAREAN DELIVERY RATES true true Keyword 2319025 /api/keyword/2319025 SECTION RATES true true SjrRating 11224845 /api/sjrrating/11224845 sjr:D1 (2021) Scopus - Medicine (miscellaneous) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 0098-7484 1538-3598 22 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true D1 DIRECT true true Reference 20985040 /api/reference/20985040 1. Warton EM., PAPER 25 2018 OOPS D 1 false true Reference 20985039 /api/reference/20985039 2. VanGompel EW, 2018, BMC PREGNANCY CHILDB, V18, DOI 10.1186/s12884-018-1756-7 2 false true Reference 20985038 /api/reference/20985038 3. VanGompel EW, 2019, HEALTH SERV RES, V54, P417, DOI 10.1111/1475-6773.13123 3 false true Reference 20985037 /api/reference/20985037 4. Valdes EG, 2020, J RACIAL ETHN HEALTH, DOI 10.1007/s40615-020-00842-3 4 false true Reference 20985036 /api/reference/20985036 5. US Centers for Disease Control and Prevention National Center for Health Statistics, VITAL STAT ONLINE 5 false true Reference 20985035 /api/reference/20985035 6. Spong CY, 2012, OBSTET GYNECOL, V120, P1181, DOI [http://10.1097/AOG.0b013e3182704880, 10.1097/AOG.0b013e3182704880] 6 false true Reference 20985034 /api/reference/20985034 7. Smith H., 2016, TOOLKIT SUPPORT VAGI 7 false true Reference 20985033 /api/reference/20985033 8. Sebastiao YV, 2016, AM J OBSTET GYNECOL, V214, DOI 10.1016/j.ajog.2015.08.027 8 false true Reference 20985032 /api/reference/20985032 9. Office of Disease Prevention and Health Promotion, HLTH PEOPLE 2020 TOP 9 false true Reference 20985031 /api/reference/20985031 10. Nilsen P., 2020, HDB IMPLEMENTATION S 10 false true Reference 20985030 /api/reference/20985030 11. National Center for Health Statistics, 2016, HLTH PEOPLE 2020 MID 11 false true Reference 20985029 /api/reference/20985029 12. Martin Joyce A, 2019, Natl Vital Stat Rep, V68, P1 12 false true Reference 20985028 /api/reference/20985028 13. Main EK, 2012, OBSTET GYNECOL, V120, P1194, DOI [http://10.1097/AOG.0b013e31826fc13d, 10.1097/AOG.0b013e31826fc13d] 13 false true Reference 20985027 /api/reference/20985027 14. Main EK, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2017.01.017 14 false true Reference 20985026 /api/reference/20985026 15. Main EK, 2018, JT COMM J QUAL PATIE, V44, P250, DOI 10.1016/j.jcjq.2017.11.005 15 false true Reference 20985025 /api/reference/20985025 16. Main EK, 2018, HEALTH AFFAIR, V37, P1484, DOI 10.1377/hlthaff.2018.0463 16 false true Reference 20985024 /api/reference/20985024 17. Main EK, 2019, OBSTET GYNECOL, V133, P613, DOI 10.1097/AOG.0000000000003109 17 false true Reference 20985023 /api/reference/20985023 18. Main E K, 1999, Pediatrics, V103, P374 18 false true Reference 20985022 /api/reference/20985022 19. Lazenbatt AE., 2002, EVALUATION HDB HLTH, DOI [10.4324/9780203994498, DOI 10.4324/9780203994498] 19 false true Reference 20985021 /api/reference/20985021 20. Landry S, 2020, MATERN CHILD HLTH J, V24, P405, DOI 10.1007/s10995-020-02894-7 20 false true Reference 20985020 /api/reference/20985020 21. Kozhimannil KB, 2013, HEALTH AFFAIR, V32, P527, DOI 10.1377/hlthaff.2012.1030 21 false true Reference 20985019 /api/reference/20985019 22. Joint Commission, SPECIFICATIONS MANUA 22 false true Reference 20985018 /api/reference/20985018 23. Hussey MA, 2007, CONTEMP CLIN TRIALS, V28, P182, DOI 10.1016/j.cct.2006.05.007 23 false true Reference 20985017 /api/reference/20985017 24. Health Resources and Services Administration, LIST RURAL COUNTIES 24 false true Reference 20985016 /api/reference/20985016 25. Gude WT, 2019, IMPLEMENT SCI, V14, DOI 10.1186/s13012-019-0887-1 25 false true Reference 20985015 /api/reference/20985015 26. Gilbert WM, 2013, JT COMM J QUAL PATIE, V39, P258, DOI 10.1016/S1553-7250(13)39035-7 26 false true Reference 20985014 /api/reference/20985014 27. Getahun D, 2009, AM J OBSTET GYNECOL, V201, DOI 10.1016/j.ajog.2009.07.062 27 false true Reference 20985013 /api/reference/20985013 28. Flamm BL, 1998, BIRTH-ISS PERINAT C, V25, P117, DOI 10.1046/j.1523-536x.1998.00117.x 28 false true Reference 20985012 /api/reference/20985012 29. Davidoff F, 2005, QUAL SAF HEALTH CARE, V14, P319, DOI 10.1136/qshc.2005.014787 29 false true Reference 20985011 /api/reference/20985011 30. Danielsen B., PROBABILISTIC RECORD 30 false true Reference 20985010 /api/reference/20985010 31. Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50 31 false true Reference 20985009 /api/reference/20985009 32. Covered California, ATTACHMENT 7 COVERED 32 false true Reference 20985008 /api/reference/20985008 33. Chaillet N, 2015, NEW ENGL J MED, V372, P1710, DOI 10.1056/NEJMoa1407120 33 false true Reference 20985007 /api/reference/20985007 34. Chaillet N, 2007, BIRTH-ISS PERINAT C, V34, P53, DOI 10.1111/j.1523-536X.2006.00146.x 34 false true Reference 20985006 /api/reference/20985006 35. Caceres IA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057817 35 false true Reference 20985005 /api/reference/20985005 36. Blackmon L, 2004, PEDIATRICS, V114, P1341, DOI 10.1542/peds.2004-1697 36 false true Reference 20985004 /api/reference/20985004 37. Betran AP, 2016, BJOG-INT J OBSTET GY, V123, P667, DOI 10.1111/1471-0528.13526 37 false true Reference 20985003 /api/reference/20985003 38. Alliance for Innovation on Maternal Health, PATIENT SAFETY BUNDL 38 false true Reference 20985002 /api/reference/20985002 39. Ahern J, 2009, AM J EPIDEMIOL, V169, P1140, DOI 10.1093/aje/kwp015 39 false true Reference 20985001 /api/reference/20985001 40. Agency for Healthcare Research and Quality, MODULE 10 ACAD DETAI 40 false true /api/publication/32050988 Amidei Claudio Barbiellini et al. Association Between Age at Diabetes Onset and Subsequent Risk of Dementia. (2021) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 0098-7484 1538-3598 325 16 1640-1649<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Amidei Claudio Barbiellini </span> ;    <span class="author-name" >Fayosse Aurore </span> ;    <span class="author-name" >Dumurgier Julien </span> ;    <span class="author-name" >Machado-Fragua Marcos D. </span> ;    <span class="author-name" mtid="10024030"><a href="/gui2/?type=authors&mode=browse&sel=10024030" target="_blank">Tabak Adam G. (<span class="authorship-author-name">Tabák Ádám</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;    <span class="author-name" >van Sloten Thomas </span> ;    <span class="author-name" >Kivimaki Mika </span> ;    <span class="author-name" >Dugravot Aline </span> ;    <span class="author-name" >Sabia Severine </span> ;    <span class="author-name" >Singh-Manoux Archana ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32050988" target="_blank">Association Between Age at Diabetes Onset and Subsequent Risk of Dementia</a></div> <div> <span class="journal-title">JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0098-7484">0098-7484</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1538-3598">1538-3598</a>)</span>: <span class="journal-volume">325</span> <span class="journal-issue">16</span> <span class="page"> pp 1640-1649 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1001/jama.2021.4001" target="_blank" href="https://doi.org/10.1001/jama.2021.4001"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000645617800021" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000645617800021"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105040432" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105040432"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33904867" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33904867&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 277</span> | Független: 269 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 254 | Scopus jelölt: 268 | WoS/Scopus jelölt: 277 | DOI jelölt: 275 (Nem nyilvános: 1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32050988&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32050988</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2021.06.02. 11:07 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Inserm U1153, Paris, France Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France Department of ...</pre> </div></div>